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| 1 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017，23，12： | 7 |
| 2 | Small RNA expression and strain specificity in the rat显示文摘 | Linse SE de Wit E de Bruijn E | | 0，，： | 1 |
| 3 | Tackling Ebola: new in sights into prophylactic and therapeutic intervention strategies 显示文摘 | De Wit E Feldmann H Munster V J | 2011 | Genome &fed2011，3，1： | 1 |
| 4 | Inhibition of novel & coronavirus replica- tion by a combination of interferon-a2b and ribavirin 显示文摘 | Falzarano D de Wit E Martellaro C Callison J Munster VJ Feldmann H | 2013 | Sci Rep2013，3，： | 1 |
| 5 | Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion显示文摘 | de Wit C Roos E Bolz SS | 2003 | Physiol Genom2003，13，2： | 1 |
| 6 | Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques 显示文摘 | Falzarano D de Wit E Rasmussen AL Feldmann F Oku- mura A Scott DP Brining D Bushmaker T Martellaro C Baseler L Benecke AG Katze MG Munster VJ Feldma- nn H | 2013 | Nat Med2013，19，10： | 1 |
| 7 | Human and avian influenzaviruses target different cells in the lower respiratory tract of humans and other mammals显示文摘 | Van Riel D Munster VJ de Wit E | 2007 | Am J Pathol2007，171，： | 1 |
| 8 | Synaptotagrnin interaction with SNAP-25 governs vesicle docking, prim- ing, and fusion triggering显示文摘 | Mohrmann R de Wit H Connell E | 2013 | Neuroscience2013，33，14： | 1 |
| 9 | H5N1 Virus Attachment to Lower Respiratory Tract 显示文摘 | Van Riel D Munster VJ de Wit E | 2006 | Science2006，312，5772： | 1 |
| 10 | Formation of an Archean continent显示文摘 | de Wit M J de Ronde C E J Tredoux M | 1992 | Nature1992，357，： | 1 |
| 11 | Sliding observers for robot manipulators显示文摘 | Canudas de Wit C Slotine J J E | 1991 | Automatica1991，27，： | 1 |
| 12 | Self-assembled poly (4-vinylpyridine) surfactant systems using alkyl and alkoxy phenylazophenols显示文摘 | Wit J de Ekenstein G A Polushkin E | 2008 | Macromolecules2008，41，12： | 1 |
| 13 | Small RNA expression and strain specificity in the rat显示文摘 | Linsen S E de Wit E de Bruijn E | 2010 | BMC Genomics2010，11，： | 1 |
| 14 | EDHF and gap junctions: impor- tant regulators of vascular tone within the microcircu- lation 显示文摘 | De Wit C Wolfle S E | 2007 | Curr Pharm Biotechnol2007，8，11： | 1 |
| 15 | Formation of an Arehaean Continent显示文摘 | De Wit M J De Ronde C E J Tredoux M C | 1992 | Nature1992，357，： | 1 |
| 16 | Connexin- dependent communication within the vascular wall: Contribution to the control of arteriolar diameter 显示文摘 | De Wit C Wolfle S E | 2006 | Adv Cardiol2006，42，： | 1 |
| 17 | Pathogenesis and transmission of swine-ori- gin 2009 A (H1N1) influenza virus in ferrets 显示文摘 | MUNSTER V J DE WIT E VAN DEN BRAND J M | 2009 | Science2009，325，： | 1 |
| 18 | Pathogenesis and transmission of swine-origin2009A(H1N1)influenza viruses in ferrets显示文摘 | Munster VJ de Wit E van den Brand JM Herfst S Schrauwen EJ Bestebroer TM van de Vijver D Boucher CA Koopmans M Rimmelzwaan GF Kuiken T Osterhaus AD Fouchier RA | 2009 | Science2009，325，5939： | 1 |
| 19 | Weekly cisplatin and daily oral etoposide is highly effective in platinum pretreated ovarian cancer显示文摘 | van der Burg M E de Wit R van Putten W L | 2002 | Br J Cancer2002，86，1： | 1 |
| 20 | Pathogenesis and transmission of swine-origin 2009 A (H 1NI ) influenza virus in ferrets 显示文摘 | Munster V J de Wit E van den Brand J M | 2009 | Science2009，325，5939： | 1 |
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