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| 1 | 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy显示文摘An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy. | Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim | 2022 | Bioactive Materials2022，7，8： | 2 |
| 2 | Formation of pyrazines from ascorbic acid and amino acids under dry-roasting conditions显示文摘 | An Adams Norbert De Kimpe | 2009 | Food Chemistry2009，，4： | 2 |
| 3 | Serological detection of strawberry mild yellow edge-associated virus显示文摘 | Jawee A Adams AN Ramsdell DC | 1995 | Acta Horticulturae1995，385，： | 1 |
| 4 | Formation of pyrazines in Maillard model systems of lysine- containing dipeptides 显示文摘 | FIEN Van Lancker AN Adams NORBERT De Kimpe | 2010 | Journal of Agricultural and Food Chemistry2010，58，： | 1 |
| 5 | Forma- tion of pyzazines in maillard model systems of lysine - con- taining dipeptides显示文摘 | Fien Van Lancker An Adams Norbert De Kimpe | 2010 | J Agric Food Chem2010，58，4： | 1 |
| 6 | A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory 显示文摘 | Blum S Moore AN Adams F etal | 1999 | J Neurosci1999，19，9： | 1 |
| 7 | A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory显示文摘 | Blum S Moore AN Adams F | 1999 | J Neurosci1999，19，9： | 1 |
| 8 | PA mitogenactivated protein kinase cascade in the CA1/CA2subfield of the dorsal hippocampus is essential for longterm spatial memory显示文摘 | Blum S Moore AN Adams F | 1999 | J Neurosci1999，19，9： | 1 |
| 9 | Structural and Functional Analysis of the Globular Head Domain of p115 Provides Insight into Membrane Tethering显示文摘 | Yu An Christine Y. Chen Bryan Moyer Piotr Rotkiewicz Marc-André Elsliger Adam Godzik Ian A. Wilson William E. Balch | 2009 | Journal of Molecular Biology2009，，1： | 1 |
| 10 | Interactions between flavour release and rheological properties in model custard desserts: Effect of starch concentration and milk fat 显示文摘 | Milda Kersiene An Adams Almantas Dubra | 2008 | Food Chemistry2008，108，4： | 1 |
| 11 | Volatile composition analysis by solid-phase microextraction applied to oak wood used in cooperage (Quercus pyrenaica and Quercus petraea): effect of botanical species and toasting process显示文摘 | António M. Jord?o Jorge M. Ricardo-da-Silva Olga Laureano An Adams Jan Demyttenaere Roland Verhé Norbert Kimpe | 2006 | Journal of Wood Science2006，，6： | 1 |
| 12 | Red meat consumption and risk of type 2 diabetes:3 cohorts of US adults and an updated meta-analysis显示文摘 | An Pan Qi Sun Adam MB | 2011 | Am J Clin Nutr2011，10，： | 1 |
| 13 | Internal stenting in malignant biliary obstruetion显示文摘 | Coqling MG Adam AN | 2001 | World J Surg2001，25，3： | 1 |
| 14 | Laboratory detection of viruses and mycoplasmalike organisms in strawberry显示文摘 | Converse RH Adams AN Barbara DJ | 1988 | Plant Disease1988，72，9： | 1 |
| 15 | Malignant biliary disease: percutaneous interventions 显示文摘 | Morgan RA Adam AN | 2001 | Tech Vasc Interv Radiol2001，4，3： | 1 |
| 16 | Internal stenting in malignant biliary obstruction 显示文摘 | Cowling MG Adam AN | 2001 | World J Surg2001，25，3： | 1 |
| 17 | Cost-effectiveness analy- sis: stress ulcer bleeding prophylaxis with proton pump inhibitors, H2 receptor antagonists显示文摘 | Barkun AN Adam V Martel M | 2013 | Value Health2013，16，1： | 1 |
| 18 | Cost-effectiveness analysis:stress ulcer bleeding prophylaxis with proton pump inhibitors,H2receptor antagonists显示文摘 | Barkun AN Adam V Martel M | 2013 | Value Health2013，16，1： | 1 |
| 19 | Cost - effectiveness analysis :stress ulcer bleeding prophylaxis with proton pump inhibitors, H2 recep- tor antagonists 显示文摘 | Barkun AN Adam V Martel M | 2013 | Value Health2013，16，1： | 1 |
| 20 | Would ivermectin for malaria control be beneficial in onchocerciasis-endemic regions?显示文摘Background:There is accumulating evidence supporting the use of ivermectin as a malaria control tool.Recent findings from the repeat ivermectin mass drug administrations for control of malaria trial demonstrated a reduced incidence of malaria in villages which received repeated ivermectin mass drug administration(MDA;six doses)compared to those who had only one round of ivermectin.Several other studies investigating the benefits of ivermectin for malaria purposes are ongoing/planned.Main text:While ivermectin MDA offers promising perspectives in the fight against malaria,we highlight the added benefits and anticipated challenges of conducting future studies in onchocerciasis-endemic regions,which are confronted with a substantial disease burden including onchocerciasis-associated epilepsy.Increasing the frequency of ivermectin MDA in such places may reduce the burden of both malaria and onchocerciasis,and allow for more entomological investigations on both the Anopheles mosquitoes and the blackflies.Upfront,acceptability and feasibility studies are needed to assess the endorsement by the local populations,as well as the programmatic feasibility of implementing ivermectin MDA several times a year.Conclusions:Onchocerciasis-endemic sites would doubly benefit from ivermectin MDA interventions,as these will alleviate onchocerciasis-associated morbidity and mortality,while potentially curbing malaria transmission.Involving onchocerciasis programs and other relevant stakeholders in the malaria/ivermectin research agenda would foster the implementation of pluri-annual MDA in target communities. | Joseph Nelson Siewe Fodjo Marina Kugler An Hotterbeekx Adam Hendy Jean-Pierre Van Geertruyden Robert Colebunders | 2019 | Infectious Diseases of Poverty2019，8，4： | 1 |
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