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| 1 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 2 | Fuzzy Control with Limited Opportunities and Response delay a Production-inventory Control Scenario显示文摘 | Arif S Zahid A | 2005 | International Journal of Approximate Reasoning2005，38，4： | 1 |
| 3 | Chemical composition of fruits of some important chestnut cultivars显示文摘 | UMRAN E CEVRIYE M ARIF S | 2006 | Brazilian Archives of Biology and Technology2006，49，2： | 1 |
| 4 | Intravascular leiomyomatosis and benign metastasizing leiomyoma:an unusual case显示文摘 | Arif S Ganesan R Spooner D | 2006 | Int J Gynecol Cancer2006，16，3： | 1 |
| 5 | Thermal stress developed during the laser cutting process:consideration of different materials显示文摘 | A F M Arif B S Yilhas | 2008 | The International Journal of Advanced Manufacturing Technology2008，37，78： | 1 |
| 6 | Predictive risk factors for patientswith cirrhosis undergoing heart surgery显示文摘 | Arif R Seppelt P Schwill S | 2012 | The Annals of Thoracic Surgery2012，94，6： | 1 |
| 7 | Laser welding of low carbon steel and thermal stress analysis 显示文摘 | Yilbas B S Arif A F M Abdul Aleem B J | 2010 | Optics & Laser Technology2010，42，5： | 1 |
| 8 | PLGA-microsphere mediated clearance of bilirubin in temporarily hyperbilirubinemic rats: An alternate strategy for the treatment of experimental jaundice 显示文摘 | Ahmad N Arif K Faisal S M | 2006 | Biochimica et Biophysica Acta2006，1760，2： | 1 |
| 9 | Characterization of Cadmium Selenide Thin Film for Solar Cell Application显示文摘 | Alamgir K Pervaiz T Arif S | | 0，，1： | 1 |
| 10 | Cemented carbide cutting tool: Laster processing and thermal stress analysis显示文摘 | YILBAS B S ARIF A F M KARATAS C AHSAN M | 2007 | Applied Surface Science2007，253，： | 1 |
| 11 | Expression of ROS-responsive genes and transcription factors after metabolic formation of H2O2in chloroplasts显示文摘 | Balazadeh S Jaspert N Arif M | 2012 | Frontiers in Plant Science2012，，3： | 1 |
| 12 | Hashimoto's thyroiditis shares features with early papillary thyroid carcinoma显示文摘 | Arif S Blanes A Diaz-Cano SJ | 2002 | Histopathology2002，41，4： | 1 |
| 13 | Hashimoto's thyroiditis shares features with early papillary thyroid carcinoma显示文摘 | Arif S Diaz S | 2002 | Histopathology2002，41，4： | 1 |
| 14 | Laser shock processing: modeling of evaporation and pressure field developed in the laser- produced cavity显示文摘 | B S Yilbas S B Mansoor A F M Arif | 2009 | Int J Adv Manuf Technol2009，42，34： | 1 |
| 15 | Peptide-Protein Interactions Suggest That Acetylation of Lysines 381 and 382 of p53 Is Important for Positive Coactivator 4-p53 Interaction显示文摘 | Debnath S Chatterjee S Arif M | 2011 | The Journal of Biological Chemistry2011，286，25： | 1 |
| 16 | Management of facial paralysis in temporal bone fractures:a prospective study analyzing 11 operated fractures显示文摘 | ULUG T ARIF ULUP IL S | 2005 | Am J Otolaryngol2005，26，： | 1 |
| 17 | Decomposition and ignition of the high-nitrogen compound triamino-guanidinium azotetrazolate(TAGZT)显示文摘 | Bryce C T Arif N A Steven F S et al | 2006 | Propellants Explosives Pyrotechnics2006，31，3： | 1 |
| 18 | Hypospermatogene-sis and spermatozoa maturation arrest in rats induced bymobile phone radiation 显示文摘 | Meo S A Arif M Rashied S | 2011 | J Coll Physicians Surg Pak2011，21，5： | 1 |
| 19 | Investigation of Half Metallicity in Fe Doped CdSe and Co Doped CdSe Materials显示文摘 | Arif S Amin B Ahmad I | | 0，，01： | 1 |
| 20 | Variations of serum sialic acid level in liver cirrhosis 显示文摘 | Arif S Najeebul Hag Hanif R | 2005 | J Ayub Med Coll Abbottabad2005，17，3： | 1 |
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