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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Effects of rosiglitazone on methionine--choline deficient diet--induced nonalcoholic steatohepatitis显示文摘 | Tahan V Imeryuz N Avsar E | 2007 | Hepatology2007，46，6： | 1 |
| 3 | Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy显示文摘 | Avsar E Empson RM | 2004 | Neuropharmacology2004，47，3： | 1 |
| 4 | Urodynamic findings in the tethered spinal cord:the effect of tethered cord division on lower urinary tract functions 显示文摘 | Balkan E Kilic N Avsar I | 2001 | Eur J Pediatr Surg2001，11，2： | 1 |
| 5 | Identification and quantifi- cation of character aroma components in fresh chevre-style goat cheese 显示文摘 | CARUNCHIAWHETSTINE M E KARAGUL - YUC- EER Y AVSAR Y K | 2003 | Journal of Food Science2003，68，8： | 1 |
| 6 | Maternal serum levels of dehydroepiandrosterone sulfate and labor induction in postterm pregnancies显示文摘 | Doganay M Erdemoglu E Avsar A F | 2004 | Int J Gynaecol Obstet2004，85，3： | 1 |
| 7 | Anthropometric breast measurement: a study of 385 Turkish female students 显示文摘 | Avsar DK Aygit AC Benlier E | 2010 | Aesthet Surg J2010，30，1： | 1 |
| 8 | Anthropometric breast measurement:a study of 385 Turkish female students显示文摘 | Avsar DK Aygit AC Benlier E | | 0，，01： | 1 |
| 9 | Effects of rosiglitazone on me- thioninecholine diet -induced nonalcoholic eteatohepatitivs 显示文摘 | Tahan V Imerya Z N Avsar E | 2007 | Hepatology2007，46，6： | 1 |
| 10 | Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis 显示文摘 | Tahan V Eren F Avsar E | 2007 | Dig Dis Sci2007，52，： | 1 |
| 11 | Identification and Quantification of Character Aroma Components in Fresh Chever-Style Goat Cheese 显示文摘 | CARUNCH1A WHETSTINE M E KARAGUL-YUCEER Y AVSAR Y K | 2003 | Food Chemistry and Toxicology2003，68，8： | 1 |
| 12 | Rosiglitazone attenuates liver inflam- mation in a rat model of nonalcoholic steatohePatitis显示文摘 | Tahan V Eren F Avsar E | 2007 | Digestive Dis- eases and Sciences2007，52，12： | 1 |
| 13 | Cleaner production opportuni- ty assessment study in SEKA Balikesir pulp and paper mill 显示文摘 | AVSAR E DEMIRER G N | 2008 | Journal of Cleaner Production2008，16，： | 1 |
| 14 | Assessments of swelling anistropy of Ankara clay显示文摘 | AVSAR E ULUSAY R SONMEZ H | | 0，，： | 1 |
| 15 | Anthropometric breast measurement:a study of 385 Turkish female students显示文摘 | AVSAR D K AYGIT A C BENLIER E | 2010 | Aesthet Surg J2010，30，1： | 1 |
| 16 | Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis 显示文摘 | Tahan V Eren F Avsar E | 2007 | Dig Dis Sci2007，52，12： | 1 |
| 17 | Assessments of Swelling anisotropy of Ankara clay 显示文摘 | Avsar E Ulusay R Sonmez H | 2009 | Engineering Geology2009，105，： | 1 |
| 18 | Evaluation of the rela-tionship between passive smoking and salivary electrolytes, protein, secretory IgA, sialic acid and amylase in young children 显示文摘 | Avsar A Darka O Bodrumlu E H | 2009 | Arch Oral Biol2009，54，5： | 1 |
| 19 | Prevention of bone loss by Panax ginseng in a rat model of inflammation-induced bone loss显示文摘 | Avsar U Karakus E Halici Z | 2013 | Cell Mol Biol (Noisy-le-grand)2013，，01： | 1 |
| 20 | Association of passive smoking with dental development in young children显示文摘 | AVSAR A TOPALOGLU B HAZAR-BODRUMLU E | 2013 | Eur J Paediatr Dent2013，14，3： | 1 |
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