| 1 | Security Requirement Management for Cloud-Assisted and Internet of Things—Enabled Smart City显示文摘The world is rapidly changing with the advance of information technology.The expansion of the Internet of Things(IoT)is a huge step in the development of the smart city.The IoT consists of connected devices that transfer information.The IoT architecture permits on-demand services to a public pool of resources.Cloud computing plays a vital role in developing IoT-enabled smart applications.The integration of cloud computing enhances the offering of distributed resources in the smart city.Improper management of security requirements of cloud-assisted IoT systems can bring about risks to availability,security,performance,condentiality,and privacy.The key reason for cloud-and IoT-enabled smart city application failure is improper security practices at the early stages of development.This article proposes a framework to collect security requirements during the initial development phase of cloud-assisted IoT-enabled smart city applications.Its three-layered architecture includes privacy preserved stakeholder analysis(PPSA),security requirement modeling and validation(SRMV),and secure cloud-assistance(SCA).A case study highlights the applicability and effectiveness of the proposed framework.A hybrid survey enables the identication and evaluation of signicant challenges. | Muhammad Usman Tariq Muhammad Babar Mian Ahmad Jan Akmal Saeed Khattak Mohammad Dahman Alshehri Abid Yahya | 2021 | Computers, Materials & Continua2021，，4： | 0 |
| 2 | Novel mutations in PDE6A and CDHR1 cause retinitis pigmentosa in Pakistani families显示文摘AIM:To investigate the genetic basis of autosomal recessive retinitis pigmentosa(arRP)in two consanguineous/endogamous Pakistani families.METHODS:Whole exome sequencing(WES)was performed on genomic DNA samples of patients with arRP to identify disease causing mutations.Sanger sequencing was performed to confirm familial segregation of identified mutations,and potential pathogenicity was determined by predictions of the mutations’functions.RESULTS:A novel homozygous frameshift mutation[NM_000440.2:c.1054delG,p.(Gln352Argfs*4);Chr5:g.149286886del(GRCh37)]in the PDE6A gene in an endogamous family and a novel homozygous splice site mutation[NM_033100.3:c.1168-1G>A,Chr10:g.85968484G>A(GRCh37)]in the CDHR1 gene in a consanguineous family were identified.The PDE6A variant p.(Gln352Argfs*4)was predicted to be deleterious or pathogenic,whilst the CDHR1 variant c.1168-1G>A was predicted to result in potential alteration of splicing.CONCLUSION:This study expands the spectrum of genetic variants for arRP in Pakistani families. | Muhammad Dawood Siying Lin Taj Ud Din Irfan Ullah Shah Niamat Khan Abid Jan Muhammad Marwan Komal Sultan Maha Nowshid Raheel Tahir Asif Naveed Ahmed Muhammad Yasin Emma LBaple Andrew HCrosby Shamim Saleha | 2021 | International Journal of Ophthalmology(English edition)2021，14，12： | 0 |
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