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| 1 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 2 | Results of percuta- neous coronary interventions in patients≥90 years of age显示文摘 | IGAL T ABID A ELI L | 2007 | Catheter Cardiovasc Interv2007，70，： | 1 |
| 3 | 显示文摘 | Hannaehi Sassi S Trabelsi M Abid L | 2006 | Rev Chir Or- thop Reparatrice Appar Mot2006，92，8： | 1 |
| 4 | Acute myocardial infarctionyoung adults with Antiphospholipid syndrome: report of two casand literature review显示文摘 | Abid L Frikha F Bahloul Z | 2011 | Pan Afr Med J2011，8，： | 1 |
| 5 | Antigenic and genetic char- acteristics of swine - origin 2009 A( H1N1 ) influenza viruses cir- culating in humans 显示文摘 | Garten R J Davis C T Russell C A Shu B Lindstrom S Balish A Sessions W M Xu X Skepner E Deyde V Okomo - Adhi- ambo M Gubareva L Barnes J Smith C B Emery S L Hillman M J Rivailler P Smagala J de Graaf M Burke D F Fouchier R A Pappas E Alpuche - Aranda C M Lopez - Gatell H Ohvera H Lopez I Myers C A Faix D Blair P J Yu C Keene K M Dotson P D Jr Boxrud D Sambol A R Abid S H St George K Bannerman T Moore A L Stringer D J Blevins P Demmler - Harrison G J Ginsberg M Kriner P Waterman S Smole S Guevara H F Belongia E A Clark P A Beatrice S T Donis R Katz J Finelli L Bridges C B Shaw M Jernigan D B Uyeki T M Smith D J Klimov A I Cox N J | 2009 | Science2009，325，5937： | 1 |
| 6 | Are healthcare pro-fessionals advising obese patients to lose weight? A trend analysis显示文摘 | Abid A Galuska D Khan L K | 2005 | Med Gen Med2005，7，4： | 1 |
| 7 | Studies on novel D-ring substituted steroidal pyrazolines as potential anti- cancer agents显示文摘 | Abid H B Bilal P M Imtiyas H L | 2010 | Steroids2010，75，： | 1 |
| 8 | FOXOl-mediated activation of Akt plays a critical role in vascular homeostasis 显示文摘 | Dharaneeswaran H Abid M R Yuan L | 2014 | Circ Res2014，115，2： | 1 |
| 9 | Results of percutaneous coronary interventions in patients 990 years of age显示文摘 | Igal T Abid A Eli L | 2007 | Catheter Cardiovasc Interv2007，70，7： | 1 |
| 10 | Effects of a low-intensity dynamic-resistance training protocol using an isokinetic dynamometer on muscular strength and aerobic capacity after coronary artery bypass grafting显示文摘 | Ghroubi S Elleuch W Abid L | 2013 | Annals of physical and rehabilitation medicine2013，3，： | 1 |
| 11 | Granulocytic sarcoma of the small intestine in a child without leukemia: report of a case with cytologic findings and immunophenolyping pitfalls 显示文摘 | Mrad K Abid L Driss M | 2004 | Acta Cytol2004，48，5： | 1 |
| 12 | Congenital heart disease in 37, 294 births in Tunisia, birth prevalence and mortality rate显示文摘 | Abid D Elloumi A Abid L | 2014 | Cardiol Young2014，24，5： | 1 |
| 13 | Natural occurrence ofochratoxin A in Tunisian cereals显示文摘 | Zaied C Abid S Zorgui L | 2009 | Food Control2009，20，3： | 1 |
| 14 | Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras显示文摘 | Pietschmann T Kaul A Koutsoudakis G Shavinskaya A Kallis S Steinmann E Abid K Negro F Dreux M Cosset F L Bartenschlager R | 2006 | Proc Natl Acad Sci USA2006，103，19： | 1 |
| 15 | Detection of the negative strand hepatitis C virus RNA in tissues;implacation for pathogenisis显示文摘 | Qudi R Rudia-Brardt L Abid K | 2001 | Antiviral Res2001，52，2： | 1 |
| 16 | i TRAQ:amethodto elucidate cellular responsesto mycotoxin zearalenone显示文摘 | Gazzah AC Camoin L Abid S | 2013 | J Appl Toxicol2013，33，7： | 1 |
| 17 | Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3显示文摘 | Rubbia-Brandt L Quadri R Abid K | | 0，，： | 1 |
| 18 | BruceUa myocarditis: a rare an- dlife- threateningcardiacofbrucenosis 显示文摘 | Abid L Frikha Z Kallel S | 2012 | Intern Med2012，51，8： | 1 |
| 19 | Congenital heart disease in 37,294 births in Tunisia: birth prevalence and mortality rate 显示文摘 | Abid D Elloumi A Abid L | 2014 | Cardiol Young2014，24，5： | 1 |
| 20 | CCR5 as a treatment target in pulmonary arterial hypertension显示文摘 | Amsellem V Lipskaia L Abid S | 2014 | Circulation2014，130，11： | 1 |
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