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| 1 | Tissue expression and developmental regulation of chicken cathelicidin antimicrobial peptides显示文摘Cathelicidins are a major family of antimicrobial peptides present in vertebrate animals with potent microbicidal and immunomodulatory activities. Four cathelicidins, namely fowlicidins 1 to 3 and cathelicidin B1, have been identified in chickens. As a first step to understand their role in early innate host defense of chickens, we examined the tissue and developmental expression patterns of all four cathelicidins. Real-time PCR revealed an abundant expression of four cathelicidins throughout the gastrointestinal, respiratory, and urogenital tracts as well as in all primary and secondary immune organs of chickens. Fowlicidins 1 to 3 exhibited a similar tissue expression pattern with the highest expression in the bone marrow and lung, while cathelicidin B1 was synthesized most abundantly in the bursa of Fabricius. Additionally, a tissue-specific regulatory pattern was evident for all four cathelicidins during the first 28 days after hatching. The expression of fowlicidins 1 to 3 showed an age-dependent increase both in the cecal tonsil and lung, whereas all four cathelicidins were peaked in the bursa on day 4 after hatching, with a gradual decline by day 28. An abrupt augmentation in the expression of fowlicidins 1 to 3 was also observed in the cecum on day 28, while the highest expression of cathelicidin B1 was seen in both the lung and cecal tonsil on day 14. Collectively, the presence of cathelicidins in a broad range of tissues and their largely enhanced expression during development are suggestive of their potential important role in early host defense and disease resistance of chickens. | Mallika Achanta Lakshmi T Sunkara Gan Dai Yugendar R Bommineni Weiyu Jiang Guolong Zhang | 2012 | Journal of Animal Science and Biotechnology2012，3，2： | 3 |
| 2 | Clinical decision support for drug related events: Moving towards better prevention显示文摘Clinical decision support(CDS) systems with automated alerts integrated into electronic medical records demonstrate efficacy for detecting medication errors(ME) and adverse drug events(ADEs). Critically ill patients are at increased risk for ME, ADEs and serious negative outcomes related to these events. Capitalizing on CDS to detect ME and prevent adverse drug related events has the potential to improve patient outcomes. The key to an effective medication safety surveillance system incorporating CDS is advancing the signals for alerts by using trajectory analyses to predict clinical events, instead of waiting for these events to occur. Additionally, incorporating cutting-edge biomarkers into alert knowledge in an effort to identify the need to adjust medication therapy portending harm will advance the current state of CDS. CDS can be taken a step further to identify drug related physiological events, which are less commonly included in surveillance systems. Predictive models for adverse events that combine patient factors with laboratory values and biomarkers are being established and these models can be the foundation for individualized CDS alerts to prevent impending ADEs. | Sandra L Kane-Gill Archita Achanta John A Kellum Steven M Handler | 2016 | World Journal of Critical Care Medicine2016，5，4： | 2 |
| 3 | SLIC superpixels compared to state-of-the-art superpixel methods 显示文摘 | ACHANTA R SHAJI A | 2012 | IEEE Transac- tions on PAMI2012，34，11： | 1 |
| 4 | Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate显示文摘 | Dunyaporn Trachootham Yan Zhou Hui Zhang Yusuke Demizu Zhao Chen Helene Pelicano Paul J. Chiao Geetha Achanta Ralph B. Arlinghaus Jinsong Liu Peng Huang | 2006 | Cancer Cell2006，，3： | 1 |
| 5 | Salient region detection and segementation 显示文摘 | ACHANTA R ESTRADA F WILS P | 2009 | ICVS2009，，： | 1 |
| 6 | Anticancer activities of novel chalcone and bis-chalcone derivatives显示文摘 | Modzelewska A Pettit C Achanta G | | 0，，10： | 1 |
| 7 | SLIC superpixels com- pared to state-of-the-art superpixel methods显示文摘 | ACHANTA R SHAJI A SMITH K | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 8 | Frequenee tuned salient region detection显示文摘 | ACHANTA R HEMAMI S ESTRADA F | 2009 | CVPR2009，，40： | 1 |
| 9 | SLIC superpixels compared to state-of-the-art superpixel methods 显示文摘 | R Achanta | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 10 | Slicsuperpixels compared to state-of-the-art superpixel methods 显示文摘 | Achanta R Shaji A Smith K | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 11 | Synergistic effect of basic fibro-blast growth factor and methylprednisolone on neuro-logical function after exoerimental spinal cord injury显示文摘 | Baffour R Achanta K Kaufman J | 1995 | J Neurosurg1995，83，10： | 1 |
| 12 | Synergistic effect of basic fibroblast growth factor and methylprednisolone on neurological function after experimental spinal cord injury显示文摘 | Baffour R Achanta K Kaufman J | 1995 | J Neurosurg1995，83，1： | 1 |
| 13 | Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression显示文摘 | Sunkara LT Achanta M Schreiber NB Bommineni YR Dai G.Jiang W Lamont S Lillehoj HS Beker A Teeter RG | | 0，，11： | 1 |
| 14 | SLIC superpixels compared to state-of-the-art superpixel methods显示文摘 | Achanta R Shaji A Smith K | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 15 | SLIC Superpixels Compared to State-of-the-Art Superpixel Methods 显示文摘 | Achanta R Shaji A Smith K | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence(S1939-3539)2012，34，11： | 1 |
| 16 | Feasibility and Effectiveness of Provider Initiated HIV Testing and Counse- ling of TB Suspects in Vizianagaram District, South India 显示文摘 | Achanta S Kumar AM Nagaraja SB | 2012 | PLoS One2012，7，41： | 1 |
| 17 | Anticancer ac- tivities of novel chalcone and bis-chalcone derivative显示文摘 | Modzelewska A Pettit C Achanta G | 2006 | Bioorg Med Chem2006，14，10： | 1 |
| 18 | SLIC superpixels comparexi to state of the art superpixel methods显示文摘 | ACHANTA R SHAJI A SMITH K | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 19 | On multicomonent, multiphase thermomechanics with interfaces显示文摘 | ACHANTA S CUSHMAN J H | 1994 | Int J Eng Sci1994，32，11： | 1 |
| 20 | SLIC superpixels compared to state-of-the-art superpixel methods显示文摘 | Achanta R Shaji A Smith K | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
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