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| 1 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 2 | role of microRNAs in the main molecular pathways of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs(miRNAs) are small noncoding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis:(1) m TOR;(2) Wnt;(3) JAK/STAT;(4) apoptosis; and(5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented mi RNA-regulated pathway in HCC is m TOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by mi RNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment. | Francesco Vasuri Michela Visani Giorgia Acquaviva Thomas Brand Michelangelo Fiorentino Annalisa Pession Giovanni Tallini Antonia D’Errico Dario de Biase | 2018 | World Journal of Gastroenterology2018，24，25： | 16 |
| 3 | Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis显示文摘 | Michele Malaguarnera Marco Vacante Tijana Antic Maria Giordano Giuseppe Chisari Rosaria Acquaviva Silvana Mastrojeni Giulia Malaguarnera Antonio Mistretta Giovanni Volti Fabio Galvano | 2012 | Digestive Diseases and Sciences2012，，2： | 2 |
| 4 | The multifaceted roles of the receptor tyrosine kinase ROS in development and cancer显示文摘 | Jaime Acquaviva Ricky Wong Al Charest | 2008 | BBA - Reviews on Cancer2008，，1： | 2 |
| 5 | Lymph node mapping and sentinel node detection in patients with cervical carcinoma:A 2-year experience 显示文摘 | Di Stefano AB Acquaviva G Garozzo G | 2005 | Gynecol Oncol2005，99，： | 1 |
| 6 | Chronic activation ofwild type epidermal growth factor receptor and loss of Cd-kn2a cause mouse glioblastoma fomiation显示文摘 | Acquaviva J Jun HJ Lessard J | 2011 | Cancer Res2011，71，23： | 1 |
| 7 | Degree of conversion of three composite materials employed in the adhesive cementation of indirect restorations:a micro-Raman analysis显示文摘 | Acquaviva P A Cerutti F Adami G | | 0，，08： | 1 |
| 8 | Effect of a synthetic surfactant on phenantherene and n-eicosane utilization by two pure marine strains grown separately in batch cultures with or without sand particles显示文摘 | Acquaviva M Bertrand J C Gilewicz M | 2001 | World Joumal of Microbiology and Biotechnology2001，17，： | 1 |
| 9 | Heme oxygenasc 1 expression in postischemid reperfusion liver damage: effect of L - arginine显示文摘 | LANTERI R ACQUAVIVA R DI GIACOMO C | 2006 | Microsurgery2006，26，1： | 1 |
| 10 | Primary hyperoxaluria Type 1: indications for screening and guidance for diagnosis and treatment显示文摘 | Cochat P Hulton SA Acquaviva C | 2012 | Nephrol Dial Transplant2012，27，： | 1 |
| 11 | N219Y, a new frequent mutation among rout(degree) forms of methylmalonic acidemia in Caucasian patients 显示文摘 | Acquaviva C Benoist JF Callebaut I | 2001 | Eur J Hum Genet2001，9，8： | 1 |
| 12 | Primary hyperoxaluria type 1: update and additional mutation analysis of the AGXT gene显示文摘 | Williams EL Acquaviva C Amoroso A | 2009 | Hum Murat2009，30，： | 1 |
| 13 | Reliable and simple analytical methods for determination of citrulline and metabolically related amino acids by liquid chromatography after derivatization:comparison between monolithic and core-shell columns显示文摘 | ACQUAVIVA A ROMERO L CASTELLS C | 2014 | Analytical Methods2014，15，15： | 1 |
| 14 | Multiple degradation pathways for los family proteins显示文摘 | Acquaviva C Boris G Ferrara P | 2002 | Arm NY Acad Sci2002，973，： | 1 |
| 15 | Polyamines levels in colorectal cancer:new markers?显示文摘 | Naso P Lanteri R Acquaviva R | 2005 | Hepatogastro-enterology2005，52，62： | 1 |
| 16 | Automated segmentation of tissue images for computer- ized IHC analysis 显示文摘 | DI Cataldo S FICARRA E ACQUAVIVA A | 2010 | Computer Methods and Programs in Biomedicine2010，100，1： | 1 |
| 17 | Propofol inhibits Caspase-3 in astroglial cells: role of heme oxygenase-1 显示文摘 | Acquaviva R Campisi A Raciti G | 2005 | Cuee Neurovase Res2005，2，2： | 1 |
| 18 | Achieving the way for automated segmentation of nuclei in cancer tissue images through morphology-based ap- proach: a quantitative evaluation 显示文摘 | DI Cataldo S FICARRA E ACQUAVIVA A | 2010 | Computerized Medical Imaging and Graphics2010，34，6： | 1 |
| 19 | Deposition of Carbon Nitride Films by Reactive Sub-Picosecond Pulsed Laser Ablation 显示文摘 | Perrone A Zocco A | 2000 | Thin Solid Films2000，373，： | 1 |
| 20 | Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury显示文摘 | Acquaviva R Lanteri R Li Destri G | 2009 | Am J Physiol Gastrointest Liver Physiol2009，296，3： | 1 |
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