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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | 骨骼肌诱导型一氧化氮合成酶基因表达和细胞凋亡在心力衰竭进展中的作用显示文摘目的 :探讨慢性充血性心力衰竭 ( CHF)患者骨骼肌中诱导型一氧化氮合成酶 ( i NOS)基因表达与反映 CHF进展指标及细胞凋亡的关系 ,进一步了解可能影响 CHF进展的因素 ,为临床 CHF的治疗提供理论依据。方法 :用反转录多聚酶链式反应 ( RT- PCR)以及脱氧核糖核酸转化酶分析方法分别测定 2 1例 CHF患者 (扩张型心肌病 14例 ,缺血性心肌病 7例 ) ,其中 NYHA分级 级 14例 , 级 7例及 8例健康人骨骼肌标本中 i NOS基因表达和细胞凋亡 ,用心肺功能测定仪对症状限制性最大氧耗 ( VO2 max)进行连续测定。结果 :健康人骨骼肌中无i NOS基因表达及细胞凋亡 ,而 2 1例 CHF患者中有 18例 ( 85 .7% )显示 i NOS表达。 NYHA 级者 i NOS基因表达较健康者有增高趋势 ,但差异无显著性意义 ( P >0 .0 5 ) ,而 NYHA 级者 i NOS基因表达显著高于 NYHA 级 ( P <0 .0 1)。 i NOS基因表达与 VO2 max呈显著负相关 ( r =- 0 .6,P <0 .0 1)。 i NOS基因高表达 ( i NOS/GAPDH率≥ 0 .3 )患者骨骼肌细胞凋亡率高于 i NOS基因中度表达 ( i NOS/ GAPDH率 <0 .3 )患者的骨骼肌细胞凋亡率 ,P <0 .0 1。结论 :i NOS基因表达与 NYHA分级和 VO2 max显著相关 ,i NOS基因表达可反映 CHF疾病进展 ,i NOS在 | 姜红 姜波 李裕舒 Adams V Hambrecht R Schuler G | 2001 | 临床心血管病杂志2001，17，10： | 3 |
| 4 | Effect of organic acids on aluminum toxicity in subsoils显示文摘 | Hue N V Craddock G R Adams F | 1986 | Soil Science Society of America Journal1986，50，： | 1 |
| 5 | Selected contribution:acute cellular and molecular responses to resistance exorcise显示文摘 | Haddad F Adams G R | 2002 | J Appl Physiol2002，93，1： | 1 |
| 6 | Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack:a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke:co-sponsored by the Council on Cardiovascular Radiology and Intervention:the American Academy of Neurology affirms the value of this guideline显示文摘 | Sacco RL Adams R Albers G | 2006 | Stroke2006，37，： | 1 |
| 7 | Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemie Attack: A Statement for Heahhcare Professionals From the American Heart Association/American Stroke Association Council on Stroke: Co- Sponsored by the Council on Cardiovascular Radiology and Intervention:The American Academy of Neurology affirms the value of this guideline显示文摘 | Sacco RL Adams R Albers G | 2006 | Stroke2006，37，2： | 1 |
| 8 | Guidelines for the early management of patients with ischemic stroke : 2005 guidelines update : a scientific statement from the Stroke Council of the American Harct Assoeiation/American Stroke Assoeiation显示文摘 | Adams H P Adams R Del Zoppo G | 2005 | Stroke2005，36，1： | 1 |
| 9 | Effect of fibre orientation and laminate geometry on the dynamic properties of CFRP显示文摘 | Adams R D Bacon D G C | 1973 | Journal of composite naaterials1973，7，4： | 1 |
| 10 | Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement forhealthcare professionals from the American Heart Association/ American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline显示文摘 | Sacco RL Adams R Albers G | 2006 | Stroke2006，37，： | 1 |
| 11 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 12 | Tne crystal structure of 4Na2SO4·2H2O2·NaCl显示文摘 | ADAMS J M PRITCHARD R G | 1978 | Acta Cryst1978，34，5： | 1 |
| 13 | Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy:amodel to predict long-term survival显示文摘 | Adam R Delvart V Pascal G | 2004 | Ann Surg2004，240，4： | 1 |
| 14 | Petroscopic observations of rock fracturing ahead of stope faces in deep-level gold mines显示文摘 | ADAMS G R JAGER A J | 1980 | Journal of the South African Institute of Mining and Metallurgy1980，80，6： | 1 |
| 15 | Tumor progression while on chemotherapy: a contradication to liver resection for multiple colorectal metastases? 显示文摘 | Adam R Pascal G Castaing D | 2004 | Ann Surg2004，240，6： | 1 |
| 16 | Localized infusion of IGF-I resuits in skeletal muscle hypertrophy in rats显示文摘 | Adams G R McCue S A | 1998 | J Appl Physiol1998，84，5： | 1 |
| 17 | Guidelines for preven- tion of stroke-in patients with ischemic stroke or transient ischemic attack: a statement for health care professionals from the American Heart Association/American Stroke Association Council on Stroke: cosponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline 显示文摘 | Sacco RL Adams R Albers G | 2006 | Stroke2006，37，2： | 1 |
| 18 | Assodation between surges of follicle stimulating hormone and the emergence of follicular waves in heifers显示文摘 | Adams G P Matted R L Kastellc J Pt | 2002 | J Reprod Fertil2002，94，： | 1 |
| 19 | Prediction and measurement of the vibrational damping parameters of carbon and glass fibre- reinforced plastics plates 显示文摘 | Lin D X Ni R G Adams R D | 1984 | Journal of Composite Materials1984，18，2： | 1 |
| 20 | Tumor progression while on chemotherapy: a contraindication to liver resection for multi- pie colorectal metastases? 显示文摘 | Adam R Pascal G Castaing D | 2004 | Ann Surg2004，240，6： | 1 |
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