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| 1 | Non-alcoholic fatty liver disease and liver transplantation:Outcomes and advances显示文摘Non-alcoholic fatty liver disease(NAFLD)is one of the most prevalent causes of chronic liver disease worldwide.In the last decade it has become the third most common indication for liver transplantation in the United States.Increasing prevalence of NAFLD in the general population also poses a risk to organ donation,as allograft steatosis can be associated with non-function of the graft.Post-transplant survival is comparable between NAFLD and non-NAFLD causes of liver disease,although long term outcomes beyond 10 year are lacking.NAFLD can recur in the allograft frequently although thus far post transplant survival has not been impacted.De novo NAFLD can also occur in the allograft of patients transplanted for non-NAFLD liver disease.Predictors for NAFLD post-transplant recurrence include obesity,hyperlipidemia and diabetes as well as steroid dose after liver transplantation.A polymorphism in PNPLA3 that mediates triglyceride hydrolysis and is linked to pre-transplant risk of obesity and NAFLD has also been linked to post transplant NAFLD risk.Although immunosuppression side effects potentiate obesity and the metabolic syndrome,studies of immunosuppression modulation and trials of specific immunosuppression regimens post-transplant are lacking in this patient population.Based on pre-transplant data,sustained weight loss through diet and exercise is the most effective therapy for NAFLD.Other agents occasionally utilized in NAFLD prior to transplantation include vitamin E and insulin-sensitizing agents.Studies of these therapies are lacking in the post-transplant population.A multimodality and multidisciplinary approach to treatment should be utilized in management of post-transplant NAFLD. | Adnan Said | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | Epidemic of non-alcoholic fatty liver disease and hepatocellular carcinoma显示文摘Non-alcoholic fatty liver disease(NAFLD) associated hepatocellular carcinoma(HCC) incidence is increasing worldwide, paralleling the obesity epidemic. Although most cases are associated with cirrhosis, HCC can occur without cirrhosis in NAFLD. Diabetes and obesity are associated risk factors for HCC in patients. Given the sheer magnitude of the underlying risk factors(diabetes, obesity, non-cirrhotic NAFLD) screening for HCC in the non-cirrhotic population is not recommended. Optimal screening strategies in NAFLD cirrhosis are not completely elucidated with Ultrasound having significant limitations in detection of liver lesions in the presence of obesity and steatosis. Consequently NAFLD-HCC is more often diagnosed at a later stage with larger tumors and reduced opportunities for curative treatments as opposed to HCC in other causes of cirrhosis. When HCC is found at a curative stage treatments including liver transplantation, resection and loco-regional therapies are associated with good results similar to that seen in HCV-HCC. Future strategies under study include the use of chemopreventive and antioxidant agents to reduce development of cirrhosis and non-alcoholic steatohepatitis(NASH). Strategies to reverse NASH via weight loss, control of associated conditions like diabetes are key strategies in reducing the increasing incidence of NASH-HCC. Novel therapeutic agents for NASH are in trials and if successful in achieving reversal of NASH will be an important strategy in reducing NAFLD-HCC. | Adnan Said Aiman Ghufran | 2017 | World Journal of Clinical Oncology2017，8，6： | 13 |
| 3 | Gut microbiome in non-alcoholic fatty liver disease associated hepatocellular carcinoma:Current knowledge and potential for therapeutics显示文摘Metabolic diseases such as nonalcoholic fatty liver disease(NAFLD)are rising in incidence and are an increasingly common cause of cirrhosis and hepatocellular carcinoma(HCC).The gut microbiome is closely connected to the liver via the portal vein,and has recently been identified as a predictor of liver disease state.Studies in NAFLD,cirrhosis and HCC have identified certain microbial signatures associated with these diseases,with the disease-associated microbiome changes collectively referred to as dysbiosis.The pathophysiologic underpinnings of these observations are an area of ongoing investigation,with current evidence demonstrating that the gut microbiome can influence liver disease and carcinogenesis via effects on intestinal permeability(leaky gut)and activation of the innate immune system.In the innate immune system,pathogen recognition receptors(Toll like receptors)on resident liver cells and macrophages cause liver inflammation,fibrosis,hepatocyte proliferation and reduced antitumor immunity,leading to chronic liver disease and carcinogenesis.Dysbiosis-associated changes include increase in secondary bile acids and reduced expression of FXR(nuclear receptor),which have also been associated with deleterious effects on lipid and carbohydrate metabolism associated with progressive liver disease.Longitudinal experimental and clinical studies are needed in different populations to examine these questions further.The role of therapeutics that modulate the microbiome is an emerging field with experimental studies showing the potential of diet,probiotics,fecal microbiota transplantation and prebiotics in improving liver disease in experimental models.Clinical studies are ongoing with preliminary evidence showing improvement in liver enzymes and steatosis.The microbial profile is different in responders to cancer immunotherapy including liver cancer,but whether or not manipulation of the microbiome can be utilized to affect response is being investigated. | Imaad Said Hassan Ahad Adnan Said | 2022 | World Journal of Gastrointestinal Oncology2022，14，5： | 6 |
| 4 | Immunoaffinity purification and characterization of glyceraldehyde-3-phosphate dehydrogenase from human erythrocytes显示文摘利用 immunoaffinity 列层析的一个新过程被用于 glyceraldehyde-3-phosphate 脱氢酶的纯化(GAPDH, EC 1.2.1.12 ) 从人的红血球。在这个快速的方法(一个步骤) 和包括铵硫酸盐分别的传统的过程之间的比较由新方法在一短时间与最高的收益给一项最高特定的活动的蓝 Sepharose CL-6B 层析表演列在后面。净化的 GAPDH 的描述表明本国的酶是有为菸碱腺嘌 dinucleotide (NAD+) 的氧化形式的绝对特性的 150 kDa 的 homotetramer。用抗体对净化的 GAPDH 提起了的净化的 monospecific polyclonal 的西方的污点分析给一个单身者看了相应于酶子单元的 36 kDa 乐队。在酶活动的温度和 pH 的效果上的研究揭示了大约 43 的最佳的价值 ? 敦瑥吗? | Driss Mountassif Tarik Baibai Latifa Fourrat Adnane Moutaouakkil Abdelghani Iddar M'Hammed Said El Kebbaj Abdelaziz S oukri | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 2 |
| 5 | Quality of life after liver transplantation. A systematic review显示文摘 | Santiago Tome Jennifer T. Wells Adnan Said Michael R. Lucey | 2008 | Journal of Hepatology2008，，4： | 1 |
| 6 | The role and clinical value of EUS in a multimodality esophageal carcinoma staging program with CT and positron emission tomography显示文摘 | Patrick R. Pfau Scott B. Perlman Peter Stanko Terrence J. Frick Deepak V. Gopal Adnan Said Zhengjun Zhang Tracey Weigel | 2007 | Gastrointestinal Endoscopy2007，，： | 1 |
| 7 | NAFLD Recurrence in Liver Transplant Recipients显示文摘 | Parul Dureja Jessica Mellinger Rashmi Agni Faye Chang Gregory Avey Michael Lucey Adnan Said | 2011 | Transplantation2011，，6： | 1 |
| 8 | Placement of Gastrostomy Tubes in Patients with Ventriculoperitoneal Shunts Does Not Result in Increased Incidence of Shunt Infection or Decreased Survival显示文摘 | Brent E. Roeder Adnan Said Mark Reichelderfer Deepak V. Gopal | 2007 | Digestive Diseases and Sciences2007，，2： | 1 |
| 9 | The Effect of ginkgo bilobn extract on free radical prodution in hypoxic rat 显示文摘 | Adnane L Said H Veronique G | 2001 | Biol Pharm Bull2001，24，6： | 1 |
| 10 | Variation in Colonoscopic Technique and Adenoma Detection Rates at an Academic Gastroenterology Unit显示文摘 | Mark E. Benson Mark Reichelderfer Adnan Said Eric A. Gaumnitz Patrick R. Pfau | 2010 | Digestive Diseases and Sciences2010，，1： | 1 |
| 11 | Model for end stage liver disease score predicts mortality across a broad spectrum of liver disease显示文摘 | Adnan Said John Williams Jeremy Holden Patrick Remington Ronald Gangnon Alexandru Musat Michael R Lucey | 2004 | Journal of Hepatology2004，，6： | 1 |
| 12 | The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: A systematic review and meta‐analysis显示文摘 | Nasia Safdar Adnan Said Michael R. Lucey | 2004 | Liver Transpl2004，，7： | 1 |
| 13 | Liver transplantation: an update 2009 显示文摘 | Catherine Skagen Michael Lucey Adnan Said | 2009 | Current Opinion in Gastroenterology2009，25，： | 1 |
| 14 | Variation in Colonoscopic Technique and Adenoma Detection Rates at an Academic Gastroenterology Unit显示文摘 | Mark E. Benson Mark Reichelderfer Adnan Said Eric A. Gaumnitz Patrick R. Pfau | 2010 | Digestive Diseases and Sciences2010，，1： | 1 |
| 15 | The role and clinical value of EUS in a multimodality esophageal carcinoma staging program with CT and positron emission tomography显示文摘 | Patrick R. Pfau Scott B. Perlman Peter Stanko Terrence J. Frick Deepak V. Gopal Adnan Said Zhengjun Zhang Tracey Weigel | 2007 | Gastrointestinal Endoscopy2007，，3： | 1 |
| 16 | Progressive collapse of 2D reinforced concrete structures under sudden column removal显示文摘Once a column in building is removed due to gas explosion,vehicle impact,terrorist attack,earthquake or any natural disaster,the loading supported by removed column transfers to neighboring structural elements.If these elements are unable to resist the supplementary loading,they continue to fail,which leads to progressive collapse of building.In this paper,an efficient strategy to model and simulate the progressive collapse of multi-story reinforced concrete structure under sudden column removal is presented.The strategy is subdivided into several connected steps including failure mechanism creation,MBS dynamic analysis and dynamic contact simulation,the latter is solved by using conserving/decaying scheme to handle the stiff nonlinear dynamic equations.The effect of gravity loads,structure-ground contact,and structure-structure contact are accounted for as well.The main novelty in this study consists in the introduction of failure function,and the proper manner to control the mechanism creation of a frame until its total failure.Moreover,this contribution pertains to a very thorough investigation of progressive collapse of the structure under sudden column removal.The proposed methodology is applied to a six-story frame,and many different progressive collapse scenarios are investigated.The results ilustrate the efficiency of the proposed strategy. | EI Houcine MOURID Said MAMOURI Adnan IBRAHIMBEGOVIC | 2020 | Frontiers of Structural and Civil Engineering2020，14，6： | 0 |
| 17 | 肝移植新进展(下)显示文摘丙型肝炎患者的肝移植——结局、抗病毒策略和免疫抑制
丙型肝炎是美国最常见的单一肝移植指征。在免疫抑制的个体中会加速复发性丙型肝炎相关肝硬化的进程,在8-44%的患者中仅需要5-7年的时间。丙型肝炎复发的患者与没有丙肝的受者相比预后明显要差得多,在超过700天的随访期中,死亡风险升高23%并且移植物衰竭的风险增加30%。因为与别的原因造成的肝病相比,丙型肝炎的预后较差(1年死亡率接近50%),因此对丙肝患者进行再移植存在争议。 | Adnan Said Michael R Lucey 姚勤伟(编译) 杨月(审校) | 2007 | 传染病网络动态2007，，4： | 0 |
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