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| 1 | miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer显示文摘AIM To investigate the clinical utility of alpha-fetoprotein(AFP)-producing gastric cancer(AFPGC)-specific microRNA(mi RNA)for monitoring and prognostic prediction of patients.METHODS We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary AFPGC.We next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their utility.We also investigated the expression levels of the selected miRNA not only in tissue but also in plasma samples.Moreover,we investigated the relationship between plasma AFP levels and plasma selected miRNA expression levels,and also investigated the correlation of the selected miRNA expression levels and malignant potential.RESULTS Among the five miRNAs selected from the miRNA array results,the expression levels of miR-122-5p were significantly higher in the AFPGC patients than in the non-AFPGC patients(P<0.05).In tissue samples,mi R-122-5p expression level tended to be lower in the non-AFPGC tissue than the normal gastric mucosa.Conversely,in the AFPGC tissue,miR-122-5p expression level was significantly higher in the AFPGC tissue than both the normal gastric mucosa and the nonAFPGC tissue samples(P<0.05).Plasma mi R-122-5p expression levels were also significantly higher in the AFPGC patients than the health volunteers and the nonAFPGC patients(P<0.05)and were strongly correlated with plasma AFP levels(r=0.7975,P<0.0001).Moreover,the correlation of miR-122-5p expression in tissue samples with malignant potential was stronger than that of plasma AFP level in the AFPGC patients.In contrast,no correlation was found between mi R-122-5p expression levels and liver metastasis in the non-AFPGC patients.CONCLUSION miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC. | Suguru Maruyama Shinji Furuya Kensuke Shiraishi Hiroki Shimizu Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Daisuke Ichikawa | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 6 |
| 2 | Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer显示文摘 | H. Tamagawa T. Oshima M. Numata N. Yamamoto M. Shiozawa S. Morinaga Y. Nakamura M. Yoshihara Y. Sakuma Y. Kameda M. Akaike N. Yukawa Y. Rino M. Masuda Y. Miyagi | 2013 | European Journal of Surgical Oncology2013，，6： | 2 |
| 3 | Expression of circadian genes correlates with liver metastasis and outcomesin colorectal cancer显示文摘 | Takashi Oshima Seiich Takenoshita Makoto Akaike Chikara Kunisaki Shoich Fujii Akito Nozaki Kazushi Numata Manabu Shiozawa Yasushi Rino Katsuaki Tanaka Munetaka Masuda Toshio Imada | 2011 | Oncology Reports2011，，5： | 2 |
| 4 | Perforating veins in recurrent esophageal varices evaluated by endoscopic color Doppler ultrasonography with a galactose-based contrast agent显示文摘 | Takahiro Sato Katsu Yamazaki Jouji Toyota Yoshiyasu Karino Takumi Ohmura Jun Akaike Yasuaki Kuwata Toshihiro Suga | 2004 | Journal of Gastroenterology2004，，5： | 2 |
| 5 | Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina显示文摘 | Katsuyuki Kaneda Satoshi Kashii Takayuki Kurosawa Shuji Kaneko Akinori Akaike Yoshihito Honda Masabumi Minami Masamichi Satoh | 1999 | Brain Research1999，，1： | 2 |
| 6 | Information Theory and an Extension of the Maximum Likelihood Principle 显示文摘 | Akaike H | 1973 | 2nd International Symposium on Information Theory1973，，： | 1 |
| 7 | A new look at the statistical model identification显示文摘 | Akaike H | 1974 | IEEE Trans on Automatic Control1974，19，6： | 1 |
| 8 | Statistical predicator identification显示文摘 | Akaike | 1969 | Annal of the Institute of Statistical Mathematics1969，，12： | 1 |
| 9 | Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro显示文摘 | Miyajina S Akaike T Matsumoto K | 2001 | Microb Pathog2001，31，6： | 1 |
| 10 | 8-nitroguanosine formation in viral pneumonia and its implication for pathogenesis显示文摘 | Akaike T Okamoto S Sawa T | 2003 | Proc Natl Acad U S A2003，100，： | 1 |
| 11 | A new look at the statistical model identification显示文摘 | Akaike H | 1974 | IEEE Trans on Automatic Control1974，19，6： | 1 |
| 12 | Role of free radicals in viral pathogenesis and mutation显示文摘 | Akaike T | 2001 | Rev Med Virol2001，11，： | 1 |
| 13 | A new look at the statistical model identification显示文摘 | AKAIKE H | 1974 | IEEE Trans on Automatic Control1974，19，6： | 1 |
| 14 | Epigallocatechin-3-gal- late and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upreguladon显示文摘 | Shimmyo Y Kihara T Akaike A | 2008 | Neuroreport2008，19，13： | 1 |
| 15 | Simulation-based medical education in clinical skills laboratory显示文摘 | Akaike M Fukutomi M Nagamune M | 2012 | J Med Invest2012，59，12： | 1 |
| 16 | Simulation-based medical edu- cation in clinical skills laboratory显示文摘 | Akaike M Fukutomi M Nagamune M | 2012 | J Med Invest2012，59，12： | 1 |
| 17 | Inductionof haem oxygenase-1, nitric oxide and ischaemia in experimental solid tumours and implications for turnour growth显示文摘 | Doi K Akaike T | 1999 | Br J Cancer1999，80，： | 1 |
| 18 | Caffeine-induced chloride current in dissociated rat hepatocytes显示文摘 | Akaike i | 1996 | Am J Physiol1996，270，2： | 1 |
| 19 | A New Look at the Statistical model Identification显示文摘 | | 1974 | IEEE Trans AC1974，19，： | 1 |
| 20 | Study of Rotational Noise Reduction for Axial Flow Fan (Analysis and Estimation of Secondary Fan-Noise Component)显示文摘 | Akaike S Kikuyama K Kitada M | 1996 | JSME International Journal Series B1996，39，3： | 1 |
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