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| 1 | Effect of atrial natriuretic peptide on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model显示文摘AIM: To evaluate the effect of ANP on warm I/R injury in a porcine THVE model. METHODS: Miniature pigs (mini-pigs) weighing 16-24 kg were observed for 120 min after reperfusion following 120 min of THVE. The animals were divided into two groups. ANP (0.1 μg/kg per min) was administered to the ANP group (n = 7), and vehicle was administered to the control group (n = 7). Either vehicle or ANP was intravenously administered from 30 min before the THVE to the end of the experiment. Arterial blood was collected to measure AST, LDH, and TNF-α. Hepatic tissue blood ? ow (HTBF) was also measured. Liver specimens were harvested for p38 MAPK analysis and histological study. Those results were compared between the two groups. RESULTS: The AST and LDH levels were lower in the ANP group than in the control group; the AST levels were signifi cantly different between the two groups (60 min: 568.7 ± 113.3 vs 321.6 ± 60.1, P = 0.038 < 0.05, 120 min: 673.6 ± 148.2 vs 281.1 ± 44.8, P = 0.004 < 0.01). No signifi cant difference was observed in the TNF-α levels between the two groups. HTBF was higher in the ANP group, but the difference was not signif icant. A signifi cantly higher level of phosphorylated p38 MAPK was observed in the ANP group compared to the controlgroup (0 min: 2.92 ± 1.1 vs 6.38 ± 1.1, P = 0.011 < 0.05).Histological tissue damage was milder in the ANP group than in the control group. CONCLUSION: Our results show that ANP has a protective role in I/R injury with p38 MAPK activation in a porcine THVE model. | Katsumi Kobayashi Kiyohiro Oshima Masato Muraoka Takahiko Akao Osamu Totsuka Hisashi Shimizu Hiroaki Sato Kazumi Tanaka Kenjiro Konno Koshi Matsumoto Izumi Takeyoshi | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Long noncoding RNA(lncRNA)HOTAIR:Pathogenic roles and therapeutic opportunities in gastric cancer显示文摘Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease.Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer.HOTAIR is an effective epigenetic agent known as long noncoding RNA(lncRNA).HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors,leading to genomic stability,proliferation,survival,invasion,migration,metastasis,and drug resistance.In the present article,we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer,whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes,leading to the development of potential therapeutic strategies. | Wencheng Kong Guang Yin Sixin Zheng Xinchun Liu Akao Zhu Panpan Yu Jian Zhang Yuqiang Shan Rongchao Ying Huicheng Jin | 2022 | Genes & Diseases2022，9，5： | 3 |
| 3 | MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer显示文摘 | Akao Zhu Jiazeng Xia Junbo Zuo Shimao Jin Hong Zhou Lubin Yao Hongyu Huang Zhijun Han | 2012 | Medical Oncology2012，，4： | 2 |
| 4 | Arsenic trioxide-induced apoptosis and its enhancement by buthionine sulfoximine in hepatocellul carcinoma cell lines显示文摘 | Kito M Akao Y Ohishi N | 2002 | Biochem Biophys Res Commun2002，291，4： | 2 |
| 5 | Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells显示文摘 | Yukihiro Akao Shunsuke Noguchi Akio Iio Keitaro Kojima Takeshi Takagi Tomoki Naoe | 2010 | Cancer Letters2010，，： | 2 |
| 6 | Balicalin, the predominant flavone glucuronide of scutellariae Radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form 显示文摘 | Akao T Kawabata K Yailagisawa E | 2000 | J Pharm Pharmacol2000，52，： | 1 |
| 7 | In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors 显示文摘 | Tang J Akao T Nakamura N | 2007 | Drug Metab Dispos2007，35，10： | 1 |
| 8 | Differential actions of cardioprotective agents on the mitochondrial death pathway 显示文摘 | Akao M O′Rourke B Hideo Kusuoka H | 2003 | Circ Res2003，92，2： | 1 |
| 9 | Angiopoietin-like proteins:potential new targets for metabolic syndrome therapy显示文摘 | Oike Y Akao M Kubota Y | 2005 | Trends Mol Med2005，11，10： | 1 |
| 10 | Mitochondrial ATP-Sensitive potassium channels attenuate Matrix Ca^2+ overload during simulated ischemia and reperfusion:Possible Mechanism of Cardioprotection显示文摘 | Mitsushige Murata Masaharu Akao Brian ORourke | 2001 | Circ Res2001，89，9： | 1 |
| 11 | Magnesium Lithospermate B is extracted rapidly into rat bile mostly as methylated metabolites,which are potent antioxidants显示文摘 | Zhang Y Akao T Nakamura N | 2004 | Drug Metab Dispos2004，32，7： | 1 |
| 12 | Apoptosis induced by an endogenous neurotoxin N-methyl(R) salsolinol, in dopamine neurons 显示文摘 | Naoi M Maruyama W Akao Y | 2000 | Toxicology2000，153，13： | 1 |
| 13 | Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis显示文摘 | KATAYAMA H YOKOTA H AKAO T | 2005 | J Biochem2005，137，1： | 1 |
| 14 | Intestinal baeterinal hydrolysis is indispensable to absorption of 1813- glycyrrhetic acid after oral administration of glycyrrhizin in rats 显示文摘 | Akao T Hayashi T Kobashi K | 1994 | J Pharm Pharmacol1994，46，： | 1 |
| 15 | Transformation of arctiinto estrogenic and antiestrogenic substances by human intes-tinal bacteria显示文摘 | Xie lihua Ahn E Akao T | 2003 | Chem Pharm Bull2003，51，4： | 1 |
| 16 | Arsenic trioxide induces apoptosisin neuroblastoma cell lines through the activation of caspase 3 in vitro显示文摘 | Akao Y Nakagawa Y Akiyama K | 1999 | FEBS Lett1999，455，12： | 1 |
| 17 | Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-κB in colon cancer cell lines显示文摘 | Nakagawa Y Akao Y | 2006 | Exp Cell Res2006，312，13： | 1 |
| 18 | Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress 显示文摘 | Teshima Y Akao M Li RA | 2003 | S roke2003，34，7： | 1 |
| 19 | Downregulation of mieroRNAs 143 and -145 in B-cell malignancies显示文摘 | Akao Y Nakagawa Y Kitade Y | 2007 | Cancer Sci2007，98，12： | 1 |
| 20 | Mitechondrial ATP-sensitive potassium channels attenuate matrix Ca2+ o- verload during simulated ischemia and reperfusion: possi- ble mechanism of cardioprotection 显示文摘 | Murata M Akao M O'Rourke B | 2001 | Circ Res2001，89，10： | 1 |
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