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| 1 | Long-term survival of a case with multiple liver metastases from duodenal gastrointestinal stromal tumor drastically reduced by the treatment with imatinib and hepatectomy显示文摘工具包受体酷氨酸激酶的组成的激活是在胃肠的基质肿瘤(大意) 的致病的一个关键因素。但是几乎没有 imatinib mesylate (IM ) 和外科疗法的联合是否能与 unresectable 在情况中延长幸存的很少信息多重肝转移。我们报导酷氨酸激酶禁止者 IM 和外科疗法对待的大意的手术后的复发的一个案例。对处理的起始的完全的反应(CR ) 为 18 瞬间继续,但是单个肝转移在 IM 处理期间在左肝的脑叶显示出生长。在再发性瘤的部分切除术以后,手术后的路线是平静的,没有复发,病人为 24 瞬间幸存。当前, imatinib 是为 non-resectable 大意的首要的治疗,但是单个代理人治疗经常导致肿瘤抵抗。就算到 imatinib 的忍耐发生, imatinib 和外科疗法的联合能在这里报导了的一些情况中延长幸存。然而,周期性的大意的很多案例上的进一步的研究是必要的评估治疗与外科相结合的 IM 的有效性。 | Chouhei Sakakura Akeo Hagiwara Koji Soga Koji Miyagawa Susumu Nakashima Tetsuji Yoshikawa Shuichi Kin Yuenn Nakase Nobuki Yamaoka Yoshihiko Sagara Hisakazu Yamagishi | 2006 | World Journal of Gastroenterology2006，12，17： | 5 |
| 2 | A novel homozygous Ile535Asn mutation in the rod cGMP phosphodiesterase beta-subunit gene in two brothers of a Japanese family with autosomal recessive retinitis pigmentosa显示文摘 | Saga M Mashima Y Akeo K | 1998 | Curr Eye Res1998，17，3： | 1 |
| 3 | The anti-proliferative effect of proliferating cell nuclear antigen-specific antisense oligonucleotides on human gastric cancer cell lines显示文摘 | Chouhei Sakakura Akeo Hagiwara Hiroyuki Tsujimoto Kimihiko Ozaki Tsuguo Sakakibara Takayuki Oyama Masaharu Ogaki Toshio Takahashi | 1995 | Surgery Today1995，，2： | 1 |
| 4 | Melanin granules prevent the cytotoxic effects of L-DOPA on retinal pigment epithelial cells in vitro by regulation of NO and superoxide radicals显示文摘 | Akeo K Amaki S Suzuki T | 2000 | Pigment Cell Res2000，13，2： | 1 |
| 5 | Oxidative stress in ocular disease显示文摘 | Ohira A Ueda T Ohishi K Hiramitsu T Akeo K Obara Y | 2008 | Nippon Ganka Gakkai Zasshi2008，112，1： | 1 |
| 6 | Growth of culture RPE and endothelial ceils is inhibited by blue light, but not green or red light显示文摘 | Dorey CK Delori FC Akeo K | 1990 | Curr Eye Res1990，9，： | 1 |
| 7 | Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors显示文摘 | Sachiko Yamaguchi Akeo Shin Kai | 1998 | Cancer Res1998，58，： | 1 |
| 8 | N-terminal domain of eotaxin-3 is important for activation of CC chemokine receptor 3显示文摘 | Akeo S Mayumi KK Naoko SN | 2002 | Protein Engineering2002，15，11： | 1 |
| 9 | Autosomal dominant retinitis pigmentosa: A Mutation in Codon 1 81 (Glu → Lys) Of the Rhodopsin Gene in a Japanese Family显示文摘 | Masamichi Saga Yukihiko Mashima Kiyoshi Akeo Yoshihisa Oguchi Jun Kudoh Nobuyoshi Shimizu | 1994 | Ophthalmic Genetics1994，，2： | 1 |
| 10 | Missense mutation of rhodopsin gene codon 15 found in Japanese autosomal dominant retinitis pigmentosa显示文摘 | Keiko Fujiki Yoshihiro Hotta Akira Murakami Masaru Yoshii Mutsuko Hayakawa Takafumi Ichikawa Misako Takeda Kiyoshi Akeo Shigekuni Okisaka Atsushi Kanai | 1995 | The Japanese Journal of Human Genetics1995，，3： | 1 |
| 11 | A novel homozygousIle535A sn mutation in the rod cGMP phosphodiesterase betasubunit gene intwo brothers of a Japanese family with autosomal recessive retinitis pigmento-sa显示文摘 | SagaM Mashima Y Akeo K | 1998 | Curr Eye R es1998，17，3： | 1 |
| 12 | Transcriotion activation mediated by a cyclic AMP receptor protein from Thermus thermophilus HB8显示文摘 | AKEO S SATOSHI K NORIKO N | 2007 | Journal of Bacteriology2007，189，10： | 1 |
| 13 | Management of postoperative follow - up and surgical treament for krukenberg tumor from colorectal cancers 显示文摘 | Chouhei S Akeo H Junya Y | 2004 | Hepato - Gastroenterology2004，51，： | 1 |
| 14 | Acute Peritonitis Caused by Intraperitoneal Rupture of an Infected Urachal Cyst: Report of a Case显示文摘 | Masaharu Ohgaki Atsushi Higuchi Hideyuki Chou Kenichiro Takashina Sadao Kawakami Yoshihiro Fujita Akeo Hagiwara Hisakazu Yamagishi | 2003 | Surgery Today2003，，1： | 1 |
| 15 | A novel homozygous Ile535Asn mutation in the rod cGMP phosphodiesterase beta-subunit gene in two brothers of a Japanese family with autosomal recessive retinitis pigmentosa显示文摘 | Saga M Mashima Y Akeo K | 1998 | Curr Eye Res1998，17，3： | 1 |
| 16 | Selective delivery of a greater amount of methotrexate to regional lymph nodes using a new dosage formation, methotrexate adsorbed on activated carbon particles in rats 显示文摘 | Akeo Hagiwara | 1994 | Anti-Cancer Drugs1994，5，： | 1 |
| 17 | Clinicopathologic characteristics and prognosis of synchronous multifocal gastric carcinomas显示文摘 | Eigo Otsuji Yoshiaki Kuriu Daisuke Ichikawa Kazuma Okamoto Akeo Hagiwara Hisakazu Yamagishi | 2005 | The American Journal of Surgery2005，，1： | 1 |
| 18 | Growth of cultured RPE and endothelial cells is inhibited by blue light but not green or red light显示文摘 | DOREY C K DELORI F C AKEO K | 1990 | Current Eye Research1990，9，6： | 1 |
| 19 | Significant expression of vascular endothelial growth factor /vascular permeability factor in mouse ascites tumor显示文摘 | Luo J Yachiko Y Akeo S K | 1998 | Cancer Res1998，58，12： | 1 |
| 20 | Effect of extensive lymph node dissection on the survival of early gastric cancer显示文摘 | Ohgaki M Toshio T Akeo H | 1999 | Hepatogastroenterology1999，46，27： | 1 |
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