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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosyn- thesis显示文摘 | Garin I Edghill EL Akerman I | 2010 | Proc Natl Acad Sci U S A2010，107，7： | 1 |
| 3 | Effects of Cd^2+ and Ca^2 upon fluxs and proliferation in concanavalin A-Stimulated lymphocytes显示文摘 | Scott I C Wslf C H Akerman K E | 1985 | Exp Cell Res1985，，： | 1 |
| 4 | Primary evaluation of the local anaesthetizes of the amino amide agent显示文摘 | Akerman B Hellberg I Trossvik C | 1988 | Acta Anaesthesiol Scand1988，32，： | 1 |
| 5 | Integration of pre-and postharvest treatments for the control of black spot caused by Alternaria alternata in stored persimmon fruit显示文摘 | Kobiler I Akerman M Huberman L | 2011 | Postharvest Biology and Technol ogy2011，59，2： | 1 |
| 6 | Integration of pre-and postharvest treatments for the control of black spot caused by Ahernaria alternate in stored persimmon fruit显示文摘 | Kobiler I Akerman M Huberman L | 2011 | Postharvest Biology and Technology2011，59，2： | 1 |
| 7 | Effect of aci- dic solutions and acidic prochloraz on the control of postharvest decay caused by Alternaria alternata in mango and persimmon fruit 显示文摘 | Prusky D Kobiler I Akerman M | 2006 | Postharvest Biology and Technology2006，42，2： | 1 |
| 8 | The level of quiescent infection of Alternaria alternata in mango fruits at harvest determines the postharvest treatment applied for the control of rots during storage显示文摘 | PRUSKY D SHALOM Y KOBILER I AKERMAN M FUCHS Y | 2002 | Postharvest Biology and Technology2002，25，3： | 1 |
| 9 | Nodular fasciitis a correlative cytologic and histologic study of 13 cases显示文摘 | Dahi I Akerman M | 1981 | Acta Cytol1981，25，3： | 1 |
| 10 | Primary evaluation of the local anaesthetic properties of the am ino amide agent ropivacaine ( LEA103 ) 显示文摘 | Akerman B Hellberg B I Trossvik C | 1988 | Acta Anaesthesiol Scand1988，32，7： | 1 |
| 11 | Human ~ cell transcriptome analysis uncovers lncRNAs that are tissue- specific, dynamically regulated, and abnormally expressed in type 2 diabetes显示文摘 | MorOn I Akerman I van de Bunt M | 2012 | Cell Metab2012，16，4： | 1 |
| 12 | Integration of pre and postharvest treatments for the control of black spot caused by Alternaria alternates in store dpersimmon fruit 显示文摘 | KOBILER L AKERMAN M HUBERMAN I | 2011 | Postharvest Biology and Technology2011，59，2： | 1 |
| 13 | In- tegration of pre-and postharvest treatment for the control of black spot caused by Alternaria alternata in stored persimmon fruit显示文摘 | KOBILER I AKERMAN M Huberman L | 2011 | Postharvest biology and technology2011，59，2： | 1 |
| 14 | Postharvest retention of the red colour of litchi fruit pericarp显示文摘 | Zauberman G Ronen R Akerman M Weksler A Rot I Fuchs Y | | 0，，： | 1 |
| 15 | Human 13 cell transcriptome analysis uncovers lneRNAs that are tissue- specific, dynamically regulated, and abnormally expressed in type 2 diabetes显示文摘 | Mor6n I Akerman I Van De Bunt M | 2012 | Cell Metab2012，16，4： | 1 |
| 16 | Primary evaluation of the local anaesthetic properties of the amino agent ropivacaine(LEA 103)显示文摘 | Akerman B Hellberg I B Trossvik C | 1988 | Acta Anaesthesiol Scand1988，32，7： | 1 |
| 17 | Human 13 cell tran- seriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated,and abnormally expressed in type 2 diabetes显示文摘 | Mor6n I Akerman l van de Bunt M | 2012 | Cell Metab2012，16，4： | 1 |
| 18 | A new potential threat in antigen and antibody products:Nanobacteria显示文摘 | Ciftcioglu N Kuronen I Akerman K | 1997 | Vaccines1997，，97： | 1 |
| 19 | Integration of preand postharvest treatments for the control of black spot caused by Alternaria altemata in stored persimmon fruit显示文摘 | Kobiler I Akerman M Huberman L | 2011 | Postharvest Biology and Technology2011，59，： | 1 |
| 20 | Aspiration cytology of soft tissue tumours: a prospective study of its influence on choice of surgical procedure 显示文摘 | Rydholm A Akerman M Idvall I | 1982 | Int Orthop1982，6，： | 1 |
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