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| 1 | Artificial intelligence in gastrointestinal endoscopy:The future is almost here显示文摘Artificial intelligence(AI) enables machines to provide unparalleled value in a myriad of industries and applications. In recent years, researchers have harnessed artificial intelligence to analyze large-volume, unstructured medical data and perform clinical tasks, such as the identification of diabetic retinopathy or the diagnosis of cutaneous malignancies. Applications of artificial intelligence techniques, specifically machine learning and more recently deep learning, are beginning to emerge in gastrointestinal endoscopy. The most promising of these efforts have been in computeraided detection and computer-aided diagnosis of colorectal polyps, with recent systems demonstrating high sensitivity and accuracy even when compared to expert human endoscopists. AI has also been utilized to identify gastrointestinal bleeding, to detect areas of inflammation, and even to diagnose certain gastrointestinal infections. Future work in the field should concentrate on creating seamless integration of AI systems with current endoscopy platforms and electronic medical records, developing training modules to teach clinicians how to use AI tools, and determining the best means for regulation and approval of new AI technology. | Muthuraman Alagappan Jeremy R Glissen Brown Yuichi Mori Tyler M Berzin | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，10： | 14 |
| 2 | Management of refractory ascites in cirrhosis:Are we out of date?显示文摘Cirrhosis is a major cause of morbidity and mortality worldwide with liver transplantations as it only possible cure.In the face of a significant organ shortage many patients die waiting.A major complication of cirrhosis is the development of portal hypertension and ascites.The management of ascites has barely evolved over the last hundred years and includes only a few milestones in our treatment approach,but has overall significantly improved patient morbidity and survival.Our mainstay to ascites management includes changes in diet,diuretics,shunt procedures,and large volume paracentesis.The understanding of the pathophysiology of cirrhosis and portal hypertension has significantly improved in the last couple of decades but the changes in ascites management have not seemed to mirror this newer knowledge.We herein review the history of ascites management and discuss some its current limitations. | Alagappan Annamalai Lauren Wisdom Megan Herada Mazen Nourredin Walid Ayoub Vinay Sundaram Andrew Klein Nicholas Nissen | 2016 | World Journal of Hepatology2016，8，28： | 4 |
| 3 | Antibacterial potential of sponge endosymbiont marine Enterobacter sp at Kavaratti Island,Lakshadweep archipelago显示文摘Objective:To isolate antibacterial potential of sponge endosymbiotic bacteria from marine sponges at Lakshadweep archipelago.Also to identify the potent bacteria by 16s rDNA sequencing and determine the antibacterial activity against clinical pathogens by MIC.Methods: Sponge samples was collected from sub-tidal habitats at Kavaratti Island and identified.The endosymbiotic bacteria were isolated and selected potential bacteria which show antibacterial activity in preliminary screening against clinical pathogens Staphylococcus aureus(S.aureus), Escherichia coli(E.coli),Salmonella typhi(S.typhi),Klebsiella pneumoniea(K.pneumoniea) and Streptococcus sp.by disc diffusion assay.The crude extracts of potential bacteria LB3 was tested against clinical pathogens by MIC.The LB3 strain was identified by 16s rDNA sequencing, 1111 bp was submitted in NCBI(HQ589912) and constructed phylogenetic tree.Results:Sponge sample was identified as Dysidea granulosa(D.granulosa) and potential bacteria LB3 identified as Enterobacter sp TTAG.Preliminary screening of sponge isolates against clinical pathogens,LB3 strain was selected as potential producer of secondary metabolites and crude extract was implies on MIC of LB3 have confirmed with lowest concentration of 5.0 mg/mL in broth medium influence of crude extract on growth inhibitory activity after 5 h of incubation period and completed the inhibitory activity at 15 h.Conclusions:The present study concluded that phylogenetic analysis of endosymbiotic bacteria Enterobacter sp from sponge D.granulosa of Lakshadweep islands showed significant antibacterial activity against clinical bacterial pathogens. | Mohan Gopi Subramanian Kumaran Thipparamalai Thangappanpillai Ajith Kumar Balaraman Deivasigamani Kumarappan Alagappan Srinivasan Guru Prasad | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 2 |
| 4 | Isolation and characterization of Pseudomonas sp. KUMS3 from Asian sea bass (Lates calcarifer) with fin rot显示文摘 | S. Kumaran B. Deivasigamani K. M. Alagappan M. Sakthivel S. Guru Prasad | 2010 | World Journal of Microbiology and Biotechnology2010，，2： | 2 |
| 5 | Cultured circulating tumor cells and their derived xenografts for personalized oncology显示文摘Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s blood.Once identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and treatment.In this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested cells.Because of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer metastasis.By analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells. | Ruoxiang Wang Gina CYChu Stefan Mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson Michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng Edwin M.Posadas Michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.Chung | 2016 | Asian Journal of Urology2016，3，4： | 2 |
| 6 | Antibiotic resistant Esherichia coli strains from seafood and its susceptibility to seaweed extracts显示文摘Objective:To determine the prevalence and antibiotic resistance of Escherichia coli(E. coli),in seafood obtained from Cuddalore and Parangipettai fish landing centres.Also,to identify the susceptibility of E.coli against predominant seaweeds red alga Kappaphycus alvarezii(K.alvarezii) and brown alga Padina boergessenii(P.boergessenii) extracts as sulfated polysaccharides and polyphenols respectively.Methods:A total of 48 samples(Two stations Cuddalore and Parangipettai,Tamil Nadu,India).Sampling area are fish landing centre where fishes caught from sea and estuary,seafood processing plants(packing and ice packed fishes) and local fish markets(fish samples).After isolation totally 80 strains were analyzed for its antimicrobial resistance and sensitivity against commercially 10 antibiotics.The ampicillin resistant E.coli CE21 was identified through molecular techniques as I6S rDNA sequencing. Two seaweeds K.alvarezii and P.boergessenii were screened lor antibacterial activity against 12 antibiotic resistant E.coli strains.Results:Totally 48 swabbed samples from two different fish handling area were characterized for total bacterial and E.coli count.Mostly,the E.coli strains were isolated from fish local market and seafood processing plants before and after packaging process.In that maximum 56.25%strains were resistant to ampicillin and the minimum 2.5%strains were resistant to chloramphenicol.Therefore,the E.coli CE21 was identified through molecular techniques E.coli(GenBank accession number GU065251),The MIC value for polyphenol extract was slightly less than sulfated polysaccharides.E.coli strain isolated from Parangipettai was considerably increased MIC value that Cuddalore.Conclusions: The polyphenol and sulfated polysaccharides showed promising inhibitory response against all antimicrobial resistant E.coli strains and in particular the inhibitory response of ampicillin resistant E.coli. | Subramanian Kumaran Balaraman Deivasiganiani Kumarappan Alagappan Mannikam Sakthivel Rajamani Karthikeyan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 1 |
| 7 | Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations显示文摘 | Soldner F Laganière J Cheng A W Hockemeyer D Gao Q Alagappan 1 Khurana V Golbe L I | | 0，，02： | 1 |
| 8 | Posterior lumbar inter- body fusion versus intertrans - verse fusion in the treatment of lumbar spondylolisthesis 显示文摘 | Inamdar DN Alagappan M Shyam L | 2006 | J Orthop Surg ( Hong Kong)2006，1，： | 1 |
| 9 | Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart 显示文摘 | DAS S ALAGAPPAN V K BAGCHI D | 2005 | Vascul Pharmacol2005，42，56： | 1 |
| 10 | Angiogenesis and vascu- lar remodeling in chronic airway diseases 显示文摘 | Alagappan VK de Boer WI Misra VK | 2013 | Cell Biochem Biophys2013，67，2： | 1 |
| 11 | Heme oxygenase-1 modulates mesangial cell proliferation by p21 Wafl upregulation 显示文摘 | Kumar D Bhaskaran M Alagappan L | 2010 | Ren Fail2010，32，2： | 1 |
| 12 | IL-1 receptor antagonist-mediated therapeutic effect in routine myasthenia gTavis is associated with suppressed serum proinflammatory cytokines, C3, and anti-acetylcholine receptor IgG1 显示文摘 | Yang H Tuzun E Alagappan D | 2005 | J Immunol2005，175，： | 1 |
| 13 | Massive intracranial immature teratoma with extracranial extension into oral cavity,nose,and neck显示文摘 | Shattuck KE Rowe T | 1998 | Fetal Diagn Ther1998，13，5： | 1 |
| 14 | Seroprevalence of tetanus antibodies among immigrants over age 50: A comparison to an aged matched US-born population显示文摘 | Alagappan K Donohue B Guzik H | 2004 | Annals of Emergency Medicine2004，44，4： | 1 |
| 15 | Enhanced bronchial expression of vascular endothelial growth factor and re- ceptors ( Flk-1 and Flt-1 ) in patients with chronic obstructive pul- monary disease 显示文摘 | Kranenburg AR de Boer WI Alagappan VK | 2005 | Thorax2005，60，2： | 1 |
| 16 | Transforming growth factor-beta 1 induces angiogenesis in vitro via VEGF production in human airway smooth muscle ceils 显示文摘 | Willems -Widyastuti A Alagappan VK Arulmani U | 2011 | Indian J Biochem Biophys2011，48，4： | 1 |
| 17 | Role of extracellular matrix and its regulation in human airway smooth muscle biology 显示文摘 | Parameswaran K Willems-Widyastuti A Alagappan V K | 2006 | Cell Biochem Biophys2006，44，1： | 1 |
| 18 | Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Fh-1 ) in patients with chronic obstructive pulmonary disease 显示文摘 | Kranenburg A R de Boer W I Alagappan V K | 2005 | Thorax2005，60，2： | 1 |
| 19 | Chromium stress in paddy:(i)Nutrient status of paddy under chromium stress;(ii) Phytoremediation of chromium by aquatic and terrestrial weeds 显示文摘 | Perumal S Alagappan C Kaliyaperumal S G | 2010 | Comptes Rendus Biologies2010，333，8： | 1 |
| 20 | Transforming growth factor-beta 1 induces angiogenesis in vitro via VEGF production in human airway smooth muscle cells显示文摘 | Willems-Widyastuti A Alagappan VK Arulmani U | 2011 | Indian J Biochem Biophys2011，48，4： | 1 |
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