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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations显示文摘 | Schmitz KJ Wohlschlaeger J Alakus H | 2007 | Virchows Arch2007，450，2： | 1 |
| 3 | Clinic pathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer显示文摘 | Alakus H Grass G Hennecken J K | 2008 | Histol Histopathol2008，23，8： | 1 |
| 4 | Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer显示文摘 | Alakus H Afriani N Warnecke-Eberz U | 2010 | World J Surg2010，34，12： | 1 |
| 5 | Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer 显示文摘 | Alakus H Afriani N Warnecke-Eberz U | 2010 | World J Surg2010，34，12： | 1 |
| 6 | ERCC1 and XRCC1 Gene Polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer显示文摘 | Warnecke-Eberz U Vallbohmer D Alakus H | 2009 | J Gastrointest Surg2009，13，8： | 1 |
| 7 | Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer显示文摘 | Alakus H Grass G Hennecken J K | 2008 | Histology and Histopathology2008，23，8： | 1 |
| 8 | ER- CC1 and XRCC1 gene polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer显示文摘 | Warnecke-Eberz U Vallb-hmer D Alakus H | 2009 | J Gastrointest Surg2009，13，8： | 1 |
| 9 | Clinic pathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer显示文摘 | Alakus H Grass G Hennecken J K | 2008 | Histol Histopathol2008，23，8： | 1 |
| 10 | Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer 显示文摘 | Alakus H Grass G Hennecken JK | 2008 | Histol Histopathol2008，23，8： | 1 |
| 11 | GNAS1 T393C poly-morphism and survival in patients with sporadic colorectal cancer显示文摘 | Frey UH Alakus H Wohlschlaeger J | 2005 | Clin Cancer Res2005，11，14： | 1 |
| 12 | Activation of extracellular regulated kinases (ERK1/2)but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations显示文摘 | Schmitz KJ Wohlschlaeger J Alakus H | 2007 | Virchows Arch2007，450，2： | 1 |
| 13 | Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer 显示文摘 | Alakus H Grass G Hennecken JK | 2008 | Histol Histopathol2008，23，8： | 1 |
| 14 | Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement显示文摘AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-and extra-capsular LNI.RESULTS:Five-year survival rate was 22.5% for the entire patient population.Patients with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was detected.Neoadjuvant therapy does not reduce the occurrence of extracapsular LNI.CONCLUSION:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant CRT.In a revised staging system for esophageal cancer,extracapsular LNI should be considered. | Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder Hakan Alakus Martin Kocher Stephan E Baldus Arnulf H Hlscher | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
| 15 | Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression显示文摘 | Alakus H Batur M Schmidt M | 2010 | Nuclear Medicine Communications:June2010，31，6： | 1 |
| 16 | Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer显示文摘 | Alakus H Grass G Hennecken J K | 2008 | Histol Histopathol2008，23，8： | 1 |
| 17 | Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression显示文摘 | Alakus H Batur M Schmidt M | | 0，，： | 1 |
| 18 | Extracapsular lymph node spread: a new prognostic factor in gastric cancer显示文摘 | Alakus H Holscher AH Grassg | 2009 | Cancer2009，116，2： | 1 |
| 19 | GNAS1T393Cpolymorphism and survival in patients with sporadic colorec-tal cancer显示文摘 | Frey UH Alakus H Wohlschlaeger J | 2005 | Clin Cancer Res2005，11，14： | 1 |
| 20 | ERCC1 and XRCC1 gene polymorphisms predict re- sponse to neoadjuvant radioehemotherapy in esophageal cancer显示文摘 | Warnecke-Eberz U Vallbohmer D Alakus H | 2009 | J Gastrointest Surg2009，13，8： | 1 |
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