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| 1 | Allocation of patients with liver cirrhosis and organ failure to intensive care: Systematic review and a proposal for clinical practice显示文摘AIM: To propose an allocation system of patients with liver cirrhosis to intensive care unit(ICU), and developed a decision tool for clinical practice. METHODS: A systematic review of the literature was performed in Pub Med, MEDLINE and EMBASE databases. The search includes studies on hospitalized patients with cirrhosis and organ failure, or acute on chronic liver failure and/or intensive care therapy. RESULTS: The initial search identified 660 potentially relevant articles. Ultimately, five articles were selected; two cohort studies and three reviews were found eligible. The literature on this topic is scarce and no studies specifically address allocation of patients with liver cirrhosis to ICU. Throughout the literature, there is consensus that selection criteria for ICU admission should be developed and validated for this group of patients and multidisciplinary approach is mandatory. Based on current available data we developed an algorithm, to determine if a patient is candidate to intensive care if needed, based on three scoring systems: premorbid Child-Pugh Score, Model of End stage Liver Disease score and the liver specific Sequential Organ Failure Assessment score.CONCLUSION: There are no established systems for allocation of patients with liver cirrhosis to the ICU and no evidence-based recommendations can be made. | Katrine Prier Lindvig Ane Sogaard Teisner Jens Kjeldsen Thomas Strom Palle Toft Valentin Furhmann Aleksander Krag | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 2 | Safety and efficacy of Profermin~to induce remission in ulcerative colitis显示文摘AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC. | Aleksander Krag Hans Israelsen Bjrn von Ryberg Klaus K Andersen Flemming Bendtsen | 2012 | World Journal of Gastroenterology2012，18，15： | 2 |
| 3 | Cardiac dysfunction in cirrhosis – does adrenal function play a role? A hypothesis显示文摘 | Eleni Theocharidou Aleksander Krag Flemming Bendtsen S?ren M?ller Andrew K. Burroughs | 2012 | Liver Int2012，，9： | 1 |
| 4 | Betablockers induce cardiac chronotropic incompetence显示文摘 | Aleksander Krag | 2011 | Journal of Hepatology2011，，1： | 1 |
| 5 | Acute kidney injury and hepatorenal syndrome in cirrhosis显示文摘 | Mads Egerod Israelsen Lise Lotte Gluud Aleksander Krag | 2015 | J Gastroenterol Hepatol2015，，： | 1 |
| 6 | Diastolic and autonomic dysfunction in early cirrhosis: a dobutamine stress study显示文摘 | Emilie Kristine Dahl Sø ren Mø ller Andreas Kjæ r Claus Leth Petersen Flemming Bendtsen Aleksander Krag | 2014 | Scandinavian Journal of Gastroenterology2014，，3： | 1 |
| 7 | Nutritional therapy in cirrhosis or alcoholic hepatitis: a systematic review and meta‐analysis显示文摘 | Annette D. Fialla Mads Israelsen Ole Hamberg Aleksander Krag Lise Lotte Gluud | 2015 | Liver Int2015，，9： | 1 |
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