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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Polarization-independent low-power integrated acousto-optic tunable filter/switch using APE/Ti polarisation splitter on lithium niobate 显示文摘 | A d' Alessandro | 1993 | Electron Lett1993，29，20： | 1 |
| 3 | Physical activity and exercise training:a relevant aspect of the dialysis patient's care 显示文摘 | Cupisti A D'Alessandro C Bottai A | 2013 | Intern Emerg Med2013，8，1： | 1 |
| 4 | Applications of Laccases and Tyrosinases (phenoloxidases) Immobilized on Different Supports:A Review显示文摘 | Nelson Durán Maria A Rosa Alessandro D'Annibale | 2002 | Enzyme and Microbial Technology2002，，31： | 1 |
| 5 | Nutrition knowledge and dietary composition in Italian adolescent female ath- letes and non-athletes显示文摘 | Cupisti A D'Alessandro C Castrogiovanni S | 2002 | International Journal of Sport Nutrition & Exercise Metabolism2002，12，2： | 1 |
| 6 | Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences 显示文摘 | Dzieciatkowska M D' Alessandro A Burke TA | 2014 | J Proteomics2014，112，： | 1 |
| 7 | Food intake and nutritional status in stable hemodialysis patients显示文摘 | Cupisti A D'Alessandro C Valeri A | 2010 | Ren Fail2010，32，： | 1 |
| 8 | Physical activity and exercise training:a relevant aspect of the dialysis patient’s care显示文摘 | Cupisti A D’alessandro C Bottai A | 2013 | Internal and Emergency Medicine2013，8，1： | 1 |
| 9 | Applications of laccases and tyrosinases(phenoloxidases)immobilized on different supports:a review显示文摘 | Nelson D Maria A R Alessandro D A | 2002 | Enzyme Microb Tech2002，31，7： | 1 |
| 10 | Symptomatic port-site hernia associated with a non-bladed trocar after laparoscopic live-donor nephrectomy显示文摘 | Lowry PS Moon TD D' Alessandro A | 2003 | J Endourol2003，17，7： | 1 |
| 11 | Effect of dietary fish oil on insulin sensitivity and metabolic fate of glucose in the skeletal muscle of normal rats显示文摘 | D'Alessandro ME Lombardo YB Chicco A | 2002 | Ann Nutr Metab2002，46，： | 1 |
| 12 | Effects of enteral feeding with eicosapentaenoic acid, γ-linolenicacid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock显示文摘 | ALESSANDRO P A AFRA MARIA A A JULIANA D A | 2006 | Crit Care Med2006，34，9： | 1 |
| 13 | Evaluation of a new rapid quantitative D-dimer assay in patients with clinically suspected deep vein thrombosis显示文摘 | D'Angelo A D'Alessandro G Tomassini L | | 0，，3： | 1 |
| 14 | How the FSH/ LH ratio and dose numbers in the p-FSH administration treat- ment regime,and insemination schedule affect superovulatory re- sponse in ewes显示文摘 | Alessandro A G D Marternucci G Taibi L | 2004 | Theriogenology2004，286，45： | 1 |
| 15 | Embryoproduction andendocrine response in ewes superovulated with PMSG,with orwithoutmonoclonal anti-PMSG administered at different timer显示文摘 | G Martemucci A D Alessandro F Toteda | 1995 | Ttreirogenology1995，44，： | 1 |
| 16 | Symptomatic port-site hernia associand with a non-bladed trocar after laparoscopie live-donor nephrectomy显示文摘 | Lowry FS Moon TD D'Alessandro A | 2003 | J Endourol2003，17，7： | 1 |
| 17 | Effector Th-1 cells with cytotoxic function in the intestinal lamina propfia of patients with Crohn' s disease 显示文摘 | Mariani P Bachetoni A Alessandro M D | 2000 | Digestive Diseases and Sciences2000，45，10： | 1 |
| 18 | Red blood cell storage: the story so far显示文摘 | D' ALESSANDRO A LIUMBRUNO G GRAZZINI G | 2010 | Blood Transfusion2010，8，2： | 1 |
| 19 | Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro显示文摘 | Tassone P Tagliaferri P Viscomi C Palmieri C Caraglia M D' Alessandro A | 2003 | Br J Cancer2003，88，： | 1 |
| 20 | Computed-tomo- graphic-guided biopsy of thoracic nodules: a revision of 583 lesions 显示文摘 | D' Alessandro V Parracino T Stranieri A | 2007 | Clin Ter2007，158，6： | 1 |
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