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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Nutritional evaluation of integral cassava root silages for growing pigs显示文摘The experiment aimed at determining the nutritional value of integral cassava root silages with yogurt as inoculant or wastewater(manipueira) by liquid addition ensiling process. Eighteen crossbred piglets(Large White x Landrace), castrated males with an initial average weight of 50 kg were allocated in metabolism cages throughout 11-day trial duration(6 days for animal's adaptation to the cages and to the experimental diets, and 5 days of urine and faeces collection). The experimental design was a randomized block arrangement with 3 treatments and 6 replicates: basal diet(100%); mixture composed of75% basal diet and 25% integral cassava root silage with yogurt as inoculant; a mixture composed of 75%of basal diet and 25% integral cassava root silage with wastewater. The silages with wastewater and yogurt presented the following values of apparent digestibility of dry matter 89.96% and 90.01%,apparent digestibility of crude protein of 60.67% and 66.43%, apparent digestibility of gross energy of90.43% and 91.48%, gross energy metabolizability coefficients of 87.88% and 88.93%, digestible energy values of 3,705 and 3,783 kcal/kg on a dry matter(DM) basis, and metabolizable energy values of 3,600 and 3,676 kcal/kg DM, respectively. The results have demonstrated that integral cassava root silages with wastewater or yogurt have a high nutritional value and can be used as an alternative energy source in growing pig's diets. | Diego D.Araújo Alessandro B.Amorim Mayra A.D.Saleh Felipe Curcelli Pedro L.Perdigón Silvio J.Bicudo Dirlei A.Berto | 2016 | Animal Nutrition2016，，3： | 5 |
| 3 | Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high‐level CpG Island methylator phenotype and mismatch repair‐deficiency显示文摘 | Heather Dawson José A. Galván Melina Helbling Dominique‐Elisabeth Muller Eva Karamitopoulou Viktor H. Koelzer Mary Economou Caroline Hammer Alessandro Lugli Inti Zlobec | 2014 | Int. J. Cancer2014，，10： | 2 |
| 4 | 6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline formation by iron mediated dopamine oxidation:a nivel route to endogenous neurotoxins under oxidative stress condition显示文摘 | Alessandra N Alessandro P Giuseppe P | 1999 | Tetrahedron Letters1999，40，14： | 1 |
| 5 | Applications of Laccases and Tyrosinases (phenoloxidases) Immobilized on Different Supports:A Review显示文摘 | Nelson Durán Maria A Rosa Alessandro D'Annibale | 2002 | Enzyme and Microbial Technology2002，，31： | 1 |
| 6 | Kelvin prove investigation of self-assembled-monolayers of thiol derivatized porphyrins interacting with volatile compounds 显示文摘 | Corrado Dinatale N Roberto Paoleasse Alessandro Mantini | 1998 | Sensors and Actuators B1998，，48： | 1 |
| 7 | Assessment of protection system positioning and models using observations of lightning strikes to structures显示文摘 | Petrov N I D' Alessandro F | 2002 | Proceedings of Royal Society Lond A2002，458，1： | 1 |
| 8 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N D~Alessandro F | 2003 | IEEE Transactions on Dielertrics and Electrical Insulation2003，10，4： | 1 |
| 9 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N D'Alessandro F | | 0，，04： | 1 |
| 10 | Infraredproperties of chemical-vapor deposition polycrystallinediamond windows显示文摘 | Paolo D Alessandro N Daniele C | 1998 | Appl Optics1998，37，24： | 1 |
| 11 | Quantification of the probability of lightning strikes to structures using a fractal approach显示文摘 | Petrov N I Petrova G N Alessandro F D | 2003 | IEEE Transactions on Dielectrics and Electrical Insulation2003，10，4： | 1 |
| 12 | Plasma met-enkephalin levels in diabetic patients: influence of autonomic neuropathy 显示文摘 | Falluoca F Tonnarini G Di Biase N D'Alessandro M Negri M | 1996 | Metabolism1996，45，： | 1 |
| 13 | Radiofrequency ablation for the treatment of radiation proctitis显示文摘 | Xavier Dray Gorgio Battaglia Dov Wengrower Pedro Gonzalez Alessandra Carlino Marine Camus Tomer Adar Francisco Pérez-Roldán Philippe Marteau Alessandro Repici | 2014 | Endoscopy2014，，： | 1 |
| 14 | Relationships between dough and bread viscoelastic properties in enzyme supplemented wheat samples显示文摘 | Clara Bollaín Alessandro Angioloni Concepción Collar | 2005 | Journal of Food Engineering2005，，3： | 1 |
| 15 | Quantification of the Probability of Lightning Strikes to Structures Using a Fractal Approach显示文摘 | PETROV N I PETROVA G N ALESSANDRO F D | | 0，，04： | 1 |
| 16 | 查看详情显示文摘 | Alessandro G Mohamed N B | | 0，，： | 1 |
| 17 | An empirical study on the determinants of essential patent claims in compatibility standards显示文摘 | RUDI B BONGARD R ALESSANDRO N | 2011 | Research Policy2011，40，7： | 1 |
| 18 | Theoretical analysis of the processes involved in lightning attachment to earthed structures显示文摘 | Petrov N I Alessandro F D | 2002 | Journal of Physics D:Applied Physics2002，，35： | 1 |
| 19 | The aetivity of amino acids produced by Paenibacillus macerans and from commercial sources against the root-knot nematode Meloidogyne exigua 显示文摘 | Denilson F O Hudson W P Alessandro S N | 2009 | European Journal of Plant Pathology2009，124，： | 1 |
| 20 | The Activity of Amino Acids Produced by Paenibacillus macerans and From Commercial Sources against the Root-knot Nematode Meloidogyne exigua显示文摘 | DENILSON F O HUDSON W P ALESSANDRO S N | 2009 | European Journal of Plant Pathology2009，124，： | 1 |
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