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| 1 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 2 | Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo显示文摘 | Alexandre J Batteux F Nicco C | 2006 | lnt J Cancer2006，119，1： | 1 |
| 3 | Molecular and morphologic characterization of a Cryptosporidium genotype identified in lemurs显示文摘 | Alexandre J Silva D Simone C | 2003 | Vet Parasitol2003，111，4： | 1 |
| 4 | Spawning of turbot(Scophthalmus maximus) in captivity显示文摘 | Devauchelle N Alexandre J C Corre L E N | 1988 | Aquaculture1988，69，： | 1 |
| 5 | Marine fish larvae feeding formulated diets or live pery 显示文摘 | Personle R J Alexandre J C Thebaud L | 1993 | J World Aquac- ult Soc1993，24，21： | 1 |
| 6 | Hard elastic carbon thin films form linking of carbon nanoparticles显示文摘 | Amaratunga G A J Chhowalla M Kiely C J Alexandrou I Aharonov R Devenish R M | 1996 | Nature (London)1996，383，： | 1 |
| 7 | Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced tumor cell death both in vitro and in vivo 显示文摘 | ALEXANDRE J BATTEUX F NICCO C | 2006 | Int J Tumor2006，1，119： | 1 |
| 8 | A new reactive pulsed laser ablation technique for the deposition of hard carbon and carbon-nitride thin films 显示文摘 | ALEXANDROU 1 ZERGIOTI 1 AMARATUNGA G A J HEALY M J F KIELY C J HATTO P VELEGRAKIS M FOTAKIS C | 1999 | Materials Letters1999，39，： | 1 |
| 9 | Changes in soluble nitrogenous compounds, caseins and free amino acids during ripening of artisanal prato cheese: a Brazilian semi-hard cows variety显示文摘 | Gorostiza A Alexandre J C Alice T V | 2004 | Food Chemistry2004，85，3： | 1 |
| 10 | Incidence and risk factors for agranulocytosis in Latin American countries—the Latin Study显示文摘 | Nelson Hamerschlak Eliane Maluf Alexandre Biasi Cavalcanti álvaro Avezum Júnior José Eluf-Neto Roberto Passeto Falc?o Irene Gyongyvér Heidemarie Lorand-Metze Daniel Goldenberg Cézar Leite Santana Daniela de Oliveira Werneck Rodrigues Leny Nascimento da Mo | 2008 | European Journal of Clinical Pharmacology2008，，9： | 1 |
| 11 | Numerical solution of the navier-stokes equations显示文摘 | ALEXANDRE J C | 1968 | Journal of Computational Mathematics1968，22，5： | 1 |
| 12 | Microarray profiling for differential gene expression in ovaries and ovarian follicles of pigs selected for increased ovulation rate显示文摘 | ALEXANDRE R C JOHNSON R K FORD J J | 2004 | Genetics2004，168，3： | 1 |
| 13 | Marine fish larvae feeding:formulated diets or live prey显示文摘 | Ruyet J P Alexandre J C Thébaud U | | 0，，02： | 1 |
| 14 | Broadband system to increase bitrate in train communication networks 显示文摘 | Rodriguez-Morcillo C Alexandres S Munoz J D | 2009 | Computer Standards & Interfaces2009，31，2： | 1 |
| 15 | Broadband system to increase bitrate in train communication networks显示文摘 | Rodriguez-Morcillo C Alexandres S Munoz J D | 2009 | Computer Standards & Interfaces2009，31，2： | 1 |
| 16 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
| 17 | Heart rate monitoring in soccer: interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bars Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength C ond Res2012，26，10： | 1 |
| 18 | Marine fish lar- vae feeding: formulated diets or live prey显示文摘 | Person L R J Alexandre J C Thbaud L | 1993 | J World Aquacult Soc1993，24，2： | 1 |
| 19 | Treatment of oxaliplatin-induced peripheral neuropathy by intravenous mangafodipir显示文摘 | Coriat R Alexandre J Nicco C | 2014 | J Clin Invest2014，124，1： | 1 |
| 20 | Nerve injury during the transpsoas approach for lumbar fusion显示文摘 | Houten J K Alexandre L C Nasser R | 2011 | J Neurosurg Spine2011，15，3： | 1 |
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