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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Poly(ethylene-co vinyl acetate)/clay Nanocomposites: Effect of Clay Nature and Organic Modifiers on Morphology,Mechanical and Thermal Properties显示文摘 | Peeterbroeck S Alexandre M Jerome R | 2005 | Polymer Degradation and Stability2005，，90： | 1 |
| 3 | Comparison between anaerobic threshold determined by ventilatory variables and blood lactate response in cyclists 显示文摘 | ALEXANDRE H O LEANDRO R A HERBERT G S | 2006 | Rev Bras Med Esporte2006，12，1： | 1 |
| 4 | Existence of infinitely many homoclinic orbits in Hamiltonian systems显示文摘 | Steven Dewitte Dominique Crommelynck Sabri Mekaoui Alexandre Joukoff Eric Séré | 1992 | Mathematische Zeitschrift1992，，1： | 1 |
| 5 | Time-domain characterization of bent coplanar waveguides显示文摘 | ALEXANDROU S SOBOLEWSKI R HSIANG T Y | | 0，，10： | 1 |
| 6 | Molecular asymmetry in extraterrestrial chemistry:Insights from a pristine meteorite显示文摘 | Pizzarello S Huang Y Alexandre M R | 2008 | Proceedings of the National Academy of Sciences2008，105，： | 1 |
| 7 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
| 8 | Heart rate monitoring in soccer: interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bars Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength C ond Res2012，26，10： | 1 |
| 9 | Extraction of ribosomal RNA and genornic DNA from soil for studying the diversity of the indigenous bacterial community 显示文摘 | Gabriela F D Alexandre S R Lucy S A C | 1998 | J Microbiol Meth1998，32，： | 1 |
| 10 | Texture analysis using graphs generated by deterministic partially self-avoiding walks显示文摘 | Andre R Backes Alexandre S Martinez Odemir M Bruno | 2011 | Pattern Recognition2011，44，： | 1 |
| 11 | Partial purification of a virus inhibitor from Silene sehafta leaves 显示文摘 | Alexandre M A V Guzzo S D Harakava R | 1997 | Fitopatologia Brasileira1997，22，2： | 1 |
| 12 | One-pot synthesis of a chitosan-based hydrogel as a potential device for magnetic biomaterial 显示文摘 | Alexandre T Paulino Marcos R Guilherme Elisangela A M S deAlmeida | 2009 | Journal of Magnetism and Magnetic Materials2009，321，17： | 1 |
| 13 | 3D reconstruction of cultural heritages:challenges and advances on precise mesh integration显示文摘 | Jurandir de O S J Alexandre V Olga R P B | 2012 | Computer Vision and Image Understanding2012，116，12： | 1 |
| 14 | Efficacyof non-thermal technologies and sanitizer solutionson microbial load reduction and quality retention ofstrawberries显示文摘 | Alexandre EMC Brandao T R S Silva C L M | 2012 | Journal of Food Engineering2012，108，3： | 1 |
| 15 | Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages显示文摘 | Cédric Rébé Magalie Raveneau Angélique Chevriaux Daniela Lakomy Anne-Laure Sberna Annie Costa Ginette Bessède Anne Athias Eric Steinmetz Jean Marc A. Lobaccaro Georges Alves Alexandre Menicacci Sébastien Vachenc Eric Solary Philippe Gambert David Masson | 2009 | Circulation Research2009，，4： | 1 |
| 16 | One-pot synthesis of a chitosan-based hhdrogel as a potential device for magnetic biomaterial 显示文摘 | Alexandre T Mareos R Elisangela A M S | 2009 | Journal of Magnetism and Magnetie Materials2009，321，17： | 1 |
| 17 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCI solution 显示文摘 | VANESSA V T ROBERTO S A CAMILA F TATIANA L F CARLOS R ALEXANDRE G T ELIANE D | 2011 | Corrosion Science2011，53，： | 1 |
| 18 | An energy-shaping approach to the design of excitation control of synchronous generators显示文摘 | Galaz M Ortega R Alexandre S B | 2003 | Automatica2003，39，1： | 1 |
| 19 | Thermal denaturation is sofid-state fermentation really a good technology for the production of enzymes显示文摘 | MARCELO M S ALEXANDRE S R | 2004 | Bioresource Technology2004，，93： | 1 |
| 20 | Ammonium complex of niobium as a precursor for the hydrothermal preparation of cellulose acetate/Nb2O5 Photocatalyst显示文摘 | Prado Alexandre G S Faria Elaine A SouzaDe Jurandir R | 2005 | Journal of Molecular CatalysisA: Chemical2005，237，： | 1 |
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