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| 1 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 2 | Role of laryngeal mask airway in laparoscopic cholecystectomy显示文摘Laparoscopic cholecystectomy is one of the most commonly performed surgical procedures and the laryngeal mask airway(LMA) is the most common supraglottic airway device used by the anesthesiologists to manage airway during general anesthesia. Use of LMA has some advantages when compared to endotracheal intubation, such as quick and ease of placement, a lesser requirement for neuromuscular blockade and a lower incidence of postoperative morbididy. However, the use of the LMA in laparoscopy is controversial, based on a concern about increased risk of regurgitation and pulmonary aspiration. The ability of these devices to provide optimal ventilation during laparoscopic procedures has been also questioned. The most important parameter to secure an adequate ventilation and oxygenation for the LMA under pneumoperitoneum condition is its seal pressure of airway. A good sealing pressure, not only state correct patient ventilation, but it reduces the potential risk of aspiration due to the better seal of airway. In addition, the LMAs incorporating a gastric access, permitting a safe anesthesia based on these commented points. We did a literature search to clarify if the use of LMA in preference to intubation provides inadequate ventilation or increase the risk of aspiration in patients undergoing laparoscopic cholecystectomy. We found evidence stating that LMA with drain channel achieves adequate ventilation for these procedures. Limited evidence was found to consider these devices completely safe against aspiration. However, we observed that the incidence of regurgitation and aspiration associated with the use of the LMA in laparoscopic surgery is very low. | José M Belena Ernesto Josué Ochoa Mónica Núnez Carlos Gilsanz Alfonso Vidal | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 4 |
| 3 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 4 | Non-ST elevation acute coronary syndrome in the elderly显示文摘1 Introduction Societies are ageing at an accelerated pace.This scenario is a well-known challenge for health care systems,as chronic diseases,multiple comorbidities and dependency are all entities that often converge in the elderly.Besides,there is an issue regarding a reduction in the general incidence of acute coronary syndrome(ACS)together with a delayed in the age of presentation,which,in sum,lead to an increase in both incidence and prevalence of ACS with age,especially non-ST elevation myocardial infarction(NSTEMI). | Pablo Díez-Villanueva César Jiménez Méndez Fernando Alfonso | 2020 | Journal of Geriatric Cardiology2020，17，1： | 4 |
| 5 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 6 | Nitrate stimulation of indigenous nitrate-reducing, sulfide-oxidising bacterial community in wastewater anaerobic blofilms 显示文摘 | Juan Garcia-de-Lomas Alfonso Corzo Portillo M Carmen | 2007 | Water Research2007，41，14： | 1 |
| 7 | Purification and properties of two endochitosanases from Mucor rouxii implicated in its cell wall degradation 显示文摘 | Alfonso C Martinez M J Reyes F | 1992 | Fems Microbiology Letters1992，95，23： | 1 |
| 8 | Thoracic en- dovascular aortic repair (TEVAR) for the treatment of aortic diseases显示文摘 | Grabenwoger M Alfonso F Bachet J | 2012 | Eur Heart J2012，33，13： | 1 |
| 9 | New polymorphisms in the IL-10 promoter region 显示文摘 | D'Alfonso S Rampi M Rolando V | 2000 | Genes Immun2000，1，3： | 1 |
| 10 | Two single-nucleotide polymorphisms in the 5'and 3'ends of the osteopontin gene contribute to susceptibility to systemic lupus erythelnatosus显示文摘 | D'Alfonso S Barizzone N Giordano M | 2005 | Arthritis Rheum2005，52，2： | 1 |
| 11 | Kinetic Analysis of the Interaction between Yessotoxin and Analogues and Immobilized Phosphodiesterases Using a Resonant Mirror Optical Biosensor显示文摘 | Pazos M J Alfonso A Vieytes M R | 2005 | Chem Res Toxicol2005，18，： | 1 |
| 12 | Carcass and meat quality in light lambs from different fat classes in the EU carcass clas- sification system显示文摘 | Sanudo C Alfonso M Sanchez A | 2000 | Meat Sci2000，56，： | 1 |
| 13 | Nitrate prmotes biological oxidation of sulfide in wastewaters:Experiment at plant-scale biotech显示文摘 | Juan G L Alfonso C Juan M G | 2006 | Bioeng2006，93，4： | 1 |
| 14 | Biological Response Modifier Activity of an Exopolysaccharide from Paenibacillus jamilae CP-7显示文摘 | Alfonso R B Maria J V Encarnacion M | 2001 | Clinical and Diagnostic Laboratory Immunology2001，8，4： | 1 |
| 15 | Effect of sesquiterpene lactones on the expression of the activation marker CD69 and of IL-2 in T-lymphocytes in whole blood 显示文摘 | Humar M Alfonso J Garcia-Pifieres AJ | 2003 | Biochem Pharmacol2003，65，9： | 1 |
| 16 | Analysis of Calorimetric Curyes Detected During the Polymorphic Transformation of Isotactic Polubutene-1显示文摘 | Alfonso GC Azzurri F Casteflano M | 2001 | Therm AnalCalorim2001，66，1： | 1 |
| 17 | Plastic ra- dii and longitudinal deformation profiles of tunnels excavatedin strain-softening rock masses显示文摘 | ALEJANO L R ALFONSO R VEIGA M | 2012 | Tunnel- ling and Underground Space Technology2012，30，： | 1 |
| 18 | Prospective application of pre-defined intravascular ultrasound crite- ria for assessment of intermediate let- main coronary artery lesions re- suits from the multicenter LITRO study 显示文摘 | De la Torre Hemandez J M Hemandez Hemandez F Alfonso F | 2011 | J Am Coll Cardiol2011，58，4： | 1 |
| 19 | Dedolomitization in different alkaline media:application to portland cement paste显示文摘 | GARCIA E ALFONSO P LABRADOR M | 2003 | Cement & Concrete Research2003，33，9： | 1 |
| 20 | Mapping of genomic regions (quamitative trait loci) controlling production and quality in industrial cultures of the edible basidiomycete Pleurotus ostreatus显示文摘 | Larraya LM Alfonso M Pisabarro AG | 2003 | Applied and Environmental Microbiology2003，69，6： | 1 |
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