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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | Diagnosis of pulmonary sequestration by spiral CT angiography 显示文摘 | Aliaga R Domingo ML | 1998 | Thorax1998，53，12： | 1 |
| 3 | Molecular cloning of cDNA and analysis of protein secondary structure of Candida albicans enolase,an abundant,immunodominant glycolytic enzyme显示文摘 | Sundstrom P Aliaga GR | | 0，，21： | 1 |
| 4 | Diagnosis of pulmonary sequestration by spiral CT angiography显示文摘 | Franco J Aliaga R Domingo ML | 1998 | Thorax1998，53，： | 1 |
| 5 | New insights into brain BDNF function in normal aging and Alzheimer disease 显示文摘 | Tapia-Arancibia L Aliaga E Silhol M | 2008 | Brain Res Rev2008，59，： | 1 |
| 6 | Thermodynamic and topological instability approaches for forecasting glass-forming ability in the ternary Al-Ni-Y system 显示文摘 | DE OLIVEIRA M F ALIAGA L C R BOLFARINI C BOTTA W J KIMINAMI C S | 2008 | J Alloys Comp2008，464，： | 1 |
| 7 | Formation and decay of the ABTS derived radical cation: a comparison of different preparation procedures 显示文摘 | HENRIOUEZ C ALIAGA C LISSI E | 2002 | international Journal of Chemical Kinetics Wiley Periodicals Inc2002，34，12： | 1 |
| 8 | Photogeometric Structured Light: A Self- calibrating And Multi-viewpoint Framework for Accurate 3D Modeling 显示文摘 | Aliaga Xu Y | 2008 | IEEE Conference on Computer Vision and Pattern Recognition2008，，： | 1 |
| 9 | Lithiasis of transplanted kidney: therapeutical potential显示文摘 | Aodrigo aliaga M Morera Martinez J Lopez Alcina E | 1996 | Arch Esp Urol1996，49，： | 1 |
| 10 | Diagnosis of pulmonary sequestration by spiral CT angiography 显示文摘 | Franco J Aliaga R Domingo ML | 1998 | Thorax1998，53，12： | 1 |
| 11 | Coalbeneficiation of Candiota mine by dry jigging 显示文摘 | C H Sampaio W Aliaga E T Pacheco | 2008 | FuelProcessing Technology2008，89，2： | 1 |
| 12 | A survey of urban reconstruction显示文摘 | Musialski P Wonka P Aliaga D G | 2013 | Computer Graphics Forum2013，32，6： | 1 |
| 13 | Dual response of BDNF to sublethal concentrations of,β-amyloid peptides in cuhured cor- tical neurons显示文摘 | Aliaga E Silhol M Bonneau N | 2010 | Neurobiol Dis2010，37，： | 1 |
| 14 | A clinical index predicting mortality with pseudomonas aeruginosa bacteraemia 显示文摘 | Aliaga L Mediavilla JD Coba F | 2002 | J Med Microbiol2002，51，7： | 1 |
| 15 | Automatic extraction of manhattan-world building masses from 3D laser range scans显示文摘 | Vanegas C A Aliaga D G Benes B | 2012 | IEEE Transactions on Visualization and Computer Graphics2012，18，10： | 1 |
| 16 | Optimization of a semi-nested multiplex PCR to identify Plasmodium parasites in wild-caught Anopheles in Bolivia, and its application to field epidemiological studies 显示文摘 | Lardeux F Tejerina R Aliaga C | 2008 | Trans R Soc Trop Med Hyg2008，102，5： | 1 |
| 17 | In vitro antiamyloidogenic properties of 1,4-naphthoquinones 显示文摘 | BERMEJO-BESCOS P MARTIN-ARAGON JIMENEZ- ALIAGA K L | 2010 | Biochem Biophys Res Comm2010，400，1： | 1 |
| 18 | Infectious Gastroenteritis and Risk of Developing Inflammatory Bowel Disease显示文摘 | Chad K. Porter David R. Tribble Pablo A. Aliaga Heather A. Halvorson Mark S. Riddle | 2008 | Gastroenterology2008，，3： | 1 |
| 19 | Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo pyrene by HPLC-MS/MS 显示文摘 | Zhang S M Chert K M Aliaga C | 2011 | Chem Res Toxicol2011，24，8： | 1 |
| 20 | Digestive utilization of goat and cow milk fat in malabsorption syndrome 显示文摘 | AlfOrez M Barrionuevo M Lopez Aliaga I | 2001 | J Dairy Res2001，68，3： | 1 |
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