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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Volatile compounds as potential defective coffee beans markers显示文摘 | ALINE T TOCI ADR1ANA F | 2008 | FoodChemistry2008，108，3： | 1 |
| 3 | Protective mucosal Th2 immune response against Toxoplasma gondii by murine mesenteric lymph node dendritic cells 显示文摘 | Dimier-Poisson I Aline F Mevelec MN | 2003 | Infect Immun2003，71，9： | 1 |
| 4 | Protective mucosal Th2 immune response against Toxoplasma gondii by murine mesenteric lymph node dendritic cells显示文摘 | Dimier-Poisson I Aline F Mevelec MN | 2003 | Infect Immun2003，71，： | 1 |
| 5 | A sinkhole resilient proto- col for wireless sensor networks: performance and security analysis 显示文摘 | Fabrice L F Antonis P Aline C V | 2012 | Computer Communications2012，35，2： | 1 |
| 6 | Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids显示文摘 | Débora Estadella Claudia M. da Penha Oller do Nascimento Lila M. Oyama Eliane B. Ribeiro Ana R. Damaso Aline de Piano Fábio Santos Lira | 2013 | Mediators of Inflammation2013，，： | 1 |
| 7 | The role of rhizobacteria in rice plants: Growth and mitigation of toxicity显示文摘Allelopathic compounds reduce the growth and productivity of upland rice plants, especially in consecutive plantations. The rhizobacteria Pseudomonas fluorescens BRM-32111 and Burkholderia pyrrocinia BRM-32113 have been recorded as growth promoters in rice. This study was developed to understand the effect of the application of rhizobacteria on upland rice plants in consecutive plantations. Experiments were conducted in a completely randomized design with four replications of four treatments: rice seed inoculated with P. fluorescens BRM-32111, rice seed inoculated with B. pyrrocinia BRM-32113(both sown on soil with rice residue), non-inoculated plants sown on soil with rice residue(control with residue(WR)), and non-inoculated plants on soil with no residue(NR). Roots and seedling growth were adversely affected by allelopathic compounds in control WR plants. Plants inoculated with rhizobacteria P. fluorescens BRM-32111 or B. pyrrocinia BRM-32113 induced an increase of 88% in biomass, 3% in the leaf area, 40% in length, 67% in root biomass, 21% in chlorophyll a, 53% in chlorophyll(a+b), 50% in rate of carbon assimilation(A), 227% in A/rubisco carboxylation efficiency(C_i) and 63% in water use efficiency(WUE) compared to control WR plants. These results indicate that rhizobacteria P. fluorescens BRM-32111 and B. pyrrocinia BRM-32113 increase the tolerance of rice plants to stress from allelochemicals. There are possible practical agricultural applications of these results for mitigating the effects of environmental allelochemistry on upland rice. | Marcela C F Rêgo Aline F Cardoso Thayná da C Ferreira Marta C C de Filippi Telma F V Batista Rafael G Viana Gisele B da Silva | 2018 | Journal of Integrative Agriculture2018，17，12： | 1 |
| 8 | Physical controls on carbon dioxide transfer velocity and flux in low-gradient river systems and implications for regional carbon budgets 显示文摘 | ALIN S R RASERA M F F L SALIMON C I | 2011 | Journal of Geophysical Research2011，，00： | 1 |
| 9 | 查看详情显示文摘 | Aline R B Emilene M B Celine L Maria G R V Sergio L C F Bernhard W | | 0，，： | 1 |
| 10 | FOSL2 promotes leptin gene expression in human and mouse adipocytes显示文摘 | Wrann Christiane D Eguchi Jun Bozec Aline Xu Zhao Mikkelsen Tarjei Gimble Jeffrey Nave Heike Wagner Erwin F Ong Shao-En Rosen Evan D | 2012 | EN2012，，3： | 1 |
| 11 | Is hydraulic retention time an essential parameter for MBR performance显示文摘 | ALINE F V GERALDO L SANTA J | 2008 | Journal of Hazardous Materials2008，150，1： | 1 |
| 12 | Chemical weathering of basaltic lava flows undergoing extreme climatic conditions: the water geochemistry record 显示文摘 | Benedetti Marc F Aline Dia Jean Riotte | 2003 | Chemical Geology2003，201，11： | 1 |
| 13 | Managing the impactof the ICD-10 transition on a data warehouse 显示文摘 | Aline F Wanderer JP Ehrenfeld JM | 2015 | J MedSyst2015，40，3： | 1 |
| 14 | Protective mucosal Th2 immune response against Toxoplasma gondii by murine mesenteric lymph node dendritic cells 显示文摘 | Aline F Mevelec MN | 2003 | Infect Immun2003，71，9： | 1 |
| 15 | Dendritic cells loaded with HIV-1 p24 proteins adsorbed on surfactant-free anionic PLA nanoparticles induce enhanced cellular immune responses against HIV-1 after vac- cination 显示文摘 | Aline F Brand D Pierre J | 2009 | Vaccine2009，27，38： | 1 |
| 16 | 显示文摘 | Aline M Lluis F Nicole H | 1997 | Hum Mol Genet1997，10，： | 1 |
| 17 | First detection of kobuvirus in farm animals in Brazil and the Netherlands 显示文摘 | Aline F B Juliane R Alice F A | 2011 | Infect Genetics and Evolution2011，11，： | 1 |
| 18 | LR1 : a candidate RNA virus of Leishmania 显示文摘 | Tarr P I Aline R F Smiley B L | 1988 | Proc Nat Acad Sci USA1988，85，： | 1 |
| 19 | Oral Administra- tion of a Live Attenuated Salmonella Vaccine Strain Expressing the VapA Protein Induces Protection against Infection by Rhodococcus equ/显示文摘 | Oliveira Aline F Ferraz L C Brocchi M | 2007 | Micro -bes and Infection2007，9，2007： | 1 |
| 20 | Induction of protective immunity against toxoplasmosis in mice by immunization with Toxoplasma gondii RNA 显示文摘 | Dimier-Poisson I Aline F Bout D et ol | 2006 | Vaccine2006，24，10： | 1 |
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