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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 3 | Requirement for FlhA in flagella assembly and swarm-cell differentiation by Proteus mirabilis显示文摘 | Gygi D Bailey M J Allison C | 1995 | Mol Microbiol1995，15，4： | 1 |
| 4 | Infrared spectroscopic studies of lyophilization-and temperature- induced protein aggregation显示文摘 | A Dong S J Prestrelski S D Allison J F Carpenter | 1995 | J Pharm Sci1995，84，： | 1 |
| 5 | Resonance response of scanning force mi- croscopy cantilevers显示文摘 | Chen G Y Warmack R J Thundat T Allison D P Huang A | 1994 | Review of Scientific Instru-ment1994，65，8： | 1 |
| 6 | Thermal and ambient-induceddeflections of scanning force microscope cantilevers显示文摘 | Thundat T Warmack R J Chen O Y Allison D P | 1994 | Applied Physics Let- ters1994，64，21： | 1 |
| 7 | Percutaneous needle biopsy of the lung 显示文摘 | Allison D J Hemingway AP | 1981 | Br Med J Clin Res Ed1981，282，6267： | 1 |
| 8 | Changes in enzymeactivities and soil microbial community composition along carbonand nutrient gradients at the Franz Josef chronosequence,NewZealand显示文摘 | ALLISON V J CONDRON L M PELTZER D A | 2007 | Soil Biological and Biochemistry2007，39，7： | 1 |
| 9 | Antipsychotic- induced weight gain:a comprehensive research synthesis显示文摘 | ALLISON D B MENTORE J L HEO M | 1999 | Am J Psychiatry1999，156，11： | 1 |
| 10 | Functional MRI cerebral activation and deactivation during finger movement显示文摘 | ALLISON J D MEADOR K J LORING D W | 2000 | Neurology2000，54，： | 1 |
| 11 | Annual Deaths Attributable to Obesity in the United States显示文摘 | ALLISON D B FONTAINE K R MANSON J E | 1999 | JAMA1999，282，： | 1 |
| 12 | Elevated serum concentrations of troponin T in acute stroke:what do they mean显示文摘 | Ghali J Allison D Kleinig T | 2010 | J Clin Neurosci2010，17，1： | 1 |
| 13 | Influence of cranberry juice on attachment of Escherichia coli to glass显示文摘 | Allison D G Cronin M A Hawker J | 2000 | Basic Microbiol2000，40，： | 1 |
| 14 | Intended and Unintended Overconsumption of Physical, Spatial, and Temporal Resources 显示文摘 | HERLOCKER C E FOUBERT J D ALLISON S T | 1997 | Journal of Personality & Social Psychology1997，73，5： | 1 |
| 15 | A review of the chemical ecology of the Cerambycidae Coleoptra)显示文摘 | Allison J D Borden J H Seybold S J | 2004 | Chemoeeology2004，14，34： | 1 |
| 16 | Annual deaths Attributable to Obesity in the United Kingdom显示文摘 | Allison D B Fontaine K R Manson J E | 1999 | The Journal of American Medical Association1999，，282： | 1 |
| 17 | A review of the chemical ecology of the Cerambycidae ( Coleoptera ) 显示文摘 | Allison J D Borden J H Seybold S J | 2004 | Chemoecology2004，14，： | 1 |
| 18 | Annual Dealths Attributable to Obesity in the United States显示文摘 | Allison D B Fontaine K R Manson J E | 1999 | Jama1999，，282： | 1 |
| 19 | Cumulative advantage and inequality in science显示文摘 | PAUL D ALLISON J SCOTT LONG | 1982 | American Sociological Review1982，47，： | 1 |
| 20 | Activities of extracellu- lar enzymes in physically isolated fractions of re- stored grassland soils显示文摘 | Allison S D Jastrow J D | 2006 | Soil Biology and Biochem- istry2006，38，： | 1 |
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