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| 1 | Telomere associated chromosome breakage in fission yeast results in variegated expression of adjacent genes 显示文摘 | Nimmo ER Cranston G Allshire RC | 1994 | EMBO J1994，13，16： | 1 |
| 2 | Sub-chronic toxicity of low concentrations of industrial volatile organic pollutants in vitro显示文摘 | Mc Dermott C Allshire A van Pelt FN | 2007 | Toxicol Appl Pharmacol2007，219，1： | 1 |
| 3 | Methylation:lost in hydroxylation显示文摘 | MCLAUGHLIN P J ALLSHIRE R C | 2005 | EMBO Rep2005，6，4： | 1 |
| 4 | RNAi and Heterochromatin-a Hushed-Up Affair显示文摘 | Allshire R | 2002 | Science2002，297，： | 1 |
| 5 | A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis显示文摘Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transit!on is not only associated with the resumption of transcription but also a wave of programmed mRNA degradation that is essential for meiotic progress!on. We explored whether terminal uridydyl transferase 4-(TUT4-) or TUT7-mediated 3' mRNA uridylation contributes to this wave of mRNA degradation during pachynema. Indeed, both TUT4 and TUT7 are expressed throughout most of spermatogenesis, however, loss of either TUT4 or TUT7 does not have any major impact upon spermatogenesis. Combined TUT4 and TUT7 (TUT4/7) deficiency results in embryonic growth defects, while conditional gene targeting revealed an essential role for TUT4/7 in pachytene progression. Loss of TUT4/7 results in the reduction of miRNA, piRNA and mRNA 31 uridylation. Although this reduction does not greatly alter miRNA or piRNA expression, TUT4/7-mediated uridylation is required for the clearanee of many zygotene-expressed transcripts in pachytene cells. We find that TUT4/7-regulated transcripts in pachytene spermatocytes are characterized by having long 3Z UTRs with length-adjusted enrichment for AU-rich elements. We also observed these features in TUT4/7-regulated maternal transcripts whose dosage was recently shown to be essential for sculpting a functional maternal transcriptome and meiosis. Therefore, mRNA 3Z uridylation is a critical determinant of both male and female germline transcriptomes. In conclusion, we have identified a novel requirement for 3' uridylation-programmed zygotene mRNA clearanee in pachytene spermatocytes that is essential for male meiotic progression. | Marcos Morgan Yuka Kabayama Christian Much Ivayla Ivanova Monica Di Giacomo Tatsiana Auchynnikava Jack Michael Monahan Dimitrios Michael Vitsios Lina Vasiliauskaite Stefano Comazzetto Juri Rappsilber Robin Campbell Allshire Bo Torben Porse Anton James Enright Donal O'Carroll | 2019 | Cell Research2019，29，3： | 1 |
| 6 | Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing 显示文摘 | SCHRAMKE V ALLSHIRE R | 2003 | Science2003，301，5636： | 1 |
| 7 | Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes显示文摘 | Nimmo ER Cranston G Allshire RC | 1994 | EMBO J1994，13，： | 1 |
| 8 | Human telomeres contain at least three types of G-rich repeat distributed non-randomly显示文摘 | Allshire R C Dempster M Hastie N D | 1989 | Nucleic Acids Research1989，17，： | 1 |
| 9 | Human telomeres contain at least three types of G-rich repeat distributed non-randomly显示文摘 | Allshire R C Dempster M Hastie N D | 1989 | Nucleic Acids Res1989，17，： | 1 |
| 10 | Selective recognition of methylated lysine 9 on histone H3 by the HPl chromo domain显示文摘 | Bannister A J Zegerman P Partridge J F Miska E A Thomas J O Allshire R C Kouzarides T | | 0，，6824： | 1 |
| 11 | Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant显示文摘 | W. C. Earnshaw R. C. Allshire B. E. Black K. Bloom B. R. Brinkley W. Brown I. M. Cheeseman K. H. A. Choo G. P. Copenhaver J. G. DeLuca A. Desai S. Diekmann S. Erhardt M. Fitzgerald-Hayes D. Foltz T. Fukagawa R. Gassmann D. W. Gerlich D. M. Glover G. J. Go | 2013 | Chromosome Research2013，，2： | 1 |
| 12 | Telomeric repeat from T thermophila cross hybridizes with human telomeres显示文摘 | Allshire RC Gosden JR Cross SH | | 0，，： | 1 |
| 13 | Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing显示文摘 | Schramke V Allshire R | 2003 | Science2003，301，： | 1 |
| 14 | RNAi and Heterochromatin-a Hushed-Up Affair显示文摘 | Allshire R | 2002 | Science2002，297，： | 1 |
| 15 | Immune modulation by cadmium and lead in the acute reporter antigen-popliteal lymph node assay显示文摘 | Allshire A van Pelt FN | 2006 | Toxicol Sci2006，91，： | 1 |
| 16 | Telomere repeat of T Thermophila cross hybridizes with human telomeres显示文摘 | Allshire RC Gosden JR Cross SH | 1998 | Nature1998，332，： | 1 |
| 17 | Epigenetic regulation of centromericchromatin:old dogs,new trieks显示文摘 | Allshire R.C Karpen G.H | | 0，，12： | 1 |
| 18 | RNA silencing and genome regulation显示文摘 | Almeida R Allshire RC | 2005 | Trends Cell Biol2005，15，5： | 1 |
| 19 | Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes显示文摘 | Nimmo ER Cranston G Allshire RC | 1994 | EMBO J1994，13，： | 1 |
| 20 | Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain显示文摘 | Bannister AJ Zegerman P Partridge JF Miska EA Thomas JO Allshire RC | 2001 | Nature2001，410，： | 1 |
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