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| 1 | Influence of environmental factors on the onset and courseof inflammatory bowel disease显示文摘Numerous environmental factors have been linked with inflammatory bowel disease. These include smoking, diet, hygiene, drugs, geographical and psychosocial factors. These factors may either increase the risk of or protect against developing this condition and can also affect the course of illness in a positive or negative manner. A number of studies have examined the influence of environmental factors on inflammatory bowel diseases as a whole as well as on ulcerative colitis and Crohn's disease separately. As there are differences in the pathogenesis of ulcerative colitis and Crohn's disease, the effect of environmental factors on their onset and course is not always similar. Some factors have shown a consistent association, while reports on others have been conflicting. In this article we discuss the current evidence on the roles of these factors on inflammatory bowel disease, both as causative/protective agents and as modifiers of disease course. | Amit Kumar Dutta Ashok Chacko | 2016 | World Journal of Gastroenterology2016，22，3： | 5 |
| 2 | Risk factors of thrombosis in abdominal veins显示文摘AIM: To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes (BCS) and splanchnic vein thrombosis (SVT). METHODS: In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group (hepatic vein, IVC thrombosis) and splanchnic venous thrombosis group (portal, splenic, superior mesenteric veins) based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients. RESULTS: Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients (28%) had hereditary and 10 patients (28%) acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group (SVT vs BCS: 45% vs 7%, χ2 = 5.7, P = 0.02) while hereditary risk factors did not show significant differences between the two groups (SVT vs BCS: 25% vs 36%, χ2 = 0.46, P = 0.7). Multiple risk factors were present in one (7%) patient with BCS and in 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT. CONCLUSION: Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factorsare significantly more common in SVT patients while hereditary factors are similar in both groups. | Amit Kumar Dutta Ashok Chacko Biju George Joseph Anjilivelil Joseph Sukesh Chandran Nair Vikram Mathews | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 3 | Duodenal villous morphology assessed using magnification narrow band imaging correlates well with histology in patients with suspected malabsorption syndrome显示文摘 | Amit Kumar Dutta Kattiparambil Gangadharan Sajith Gautam Shah Anna Benjamin Pulimood Ebby George Simon Anjilivelil Joseph Joseph Ashok Chacko | 2014 | Digestive Endoscopy2014，，6： | 1 |
| 4 | Narrow band imaging endoscopy for real-time assessment of duodenal villi显示文摘 | Amit Kumar Dutta | 2014 | Indian Journal of Gastroenterology2014，，5： | 1 |
| 5 | Emerging role of narrow band imaging in duodenum显示文摘Endoscopy using magnification narrow band imaging(m NBI) allows detailed assessment of mucosal surface and vascular pattern. This may help in better identification and prediction of the nature of the lesion. The role of this technology in duodenum is still evolving. Studies have shown that m NBI has high accuracy in predicting villous atrophy in the duodenum. Limited data suggests that this technique can provide additional information on duodenal polyps,nodules and ampullary tumour which can help guide their management. In this paper we describe the technique for duodenal assessment using NBI and review the existing literature evaluating its role in diagnosis of various duodenal pathologies. | Amit Kumar Dutta Ashok Chacko | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，16： | 1 |
| 6 | Clinical profile and predictors of disease behavior and surgery in Indian patients with Crohn’s disease显示文摘 | Ashish Goel Amit Kumar Dutta Anna B. Pulimood Anu Eapen Ashok Chacko | 2013 | Indian Journal of Gastroenterology2013，，3： | 1 |
| 7 | Treatment of Helicobacter pylori infection in the presence of penicillin allergy显示文摘Therapy of Helicobacter pylori(H.pylori)requires a combination of antibiotics together with an acid suppressing agent;most treatment regimens include Amoxicillin as one of the antibiotics,which is an important constituent as resistance to it is low.However,allergies to the penicillin group of antibiotics are not uncommon,and treating H.pylori infection in such individuals can be challenging due to the restricted choice of regimens.The aim of this review is to summarise the evidence for therapeutic options in patients with H.pylori infection and penicillin allergy.A literature search was conducted in PubMed for English language publications using the key words‘Helicobacter’and‘treatment’or‘therapy‘and‘penicillin’or‘beta-lactam’and‘allergy’or‘anaphylaxis’.Eighteen studies were identified that specifically evaluated H.pylori treatment success in penicillin allergic patients.The number of subjects in most of them was low and many were retrospective,uncontrolled,single cohort studies.The most effective option for first-line treatment appears to be Bismuth-based quadruple therapy for 10-14 d.The evidence supports second-line treatment with Levoflaxacin-based triple therapy for 10 d.Patients with persistent H.pylori infection after 2 treatment courses should be considered for testing to confirm penicillin allergy.Further treatment should be guided by the results of H.pylori culture and sensitivity testing. | Amit Kumar Dutta Perminder Singh Phull | 2021 | World Journal of Gastroenterology2021，27，44： | 1 |
| 8 | Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian显示文摘BACKGROUND Multiple genetic risk factors for Crohn’s disease(CD)have been identified.However,these observations are not consistent across different populations.The protein tyrosine phosphate non-receptor type 2(PTPN2)gene plays a role in various aspects of host defense including epithelial barrier function,autophagy,and innate and adaptive immune response.Two common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)have been associated with risk of CD in Western countries.AIM To evaluate the association of PTPN2 gene polymorphisms with risk of CD in Indian population.METHODS We conducted a prospective case-control study.Patients with CD were recruited,and their clinical and investigation details were noted.Controls were patients without organic gastrointestinal disease or other comorbid illnesses.Two common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)were assessed.DNA was extracted from peripheral blood samples of cases and controls and target DNA was amplified using specific sets of primers.The amplified fragments were digested with restriction enzymes and the presence of polymorphism was detected by restriction fragment length polymorphism.The frequency of alleles was determined.The frequencies of genotypes and alleles were compared between cases and controls to look for significant differences.RESULTS A total of 108 patients with CD(mean age 37.5±12.7 years,females 42.6%)and 100 controls(mean age 39.9±13.5 years,females 37%)were recruited.For the single nucleotide polymorphism(SNP)rs7234029,the overall frequency of G variant genotype(AG or GG)was noted to be significantly lower in the cases compared to controls(35.2%vs 50%,P=0.05).For the SNP rs2542151,the overall frequency of G variant genotype(GT or GG)was noted to be similar in cases compared to controls(43.6%vs 47%,P=0.73).There were no significant differences in minor allele(G)frequency for both polymorphisms between the cases and controls.Both the SNPs had no significant association with age of onset of illness,gender,disease location,disease behaviour,perianal disease,or extraintestinal manifestations of CD.CONCLUSION Unlike observation form the West,polymorphisms in the PTPN2 gene(rs7234029 and rs2542151)are not associated with an increased risk of developing CD in Indian patients. | Kaushik Chatterjee Amit Kumar Dutta Ashish Goel Rekha Aaron Vijayalekshmi Balakrishnan Ajith Thomas Anoop John Rajeeb Jaleel Deepu David Reuben Thomas Kurien SD Chowdhury Ebby George Simon AJ Joseph Prasanna Premkumar Anna B Pulimood | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，4： | 0 |
| 9 | Clinical outcome of orbital apex syndrome in COVID associated mucormycosis patients in a tertiary care hospital显示文摘AIM: To share clinical pattern of presentation, the modalities of surgical intervention and the one month postsurgical outcome of rhino-orbito-mucormycosis(ROCM) cases.METHODS: All COVID associated mucormycosis(CAM) patients underwent comprehensive multidisciplinar y examination by ophthalmologist, otorhinolaryngologist and physician. Patients with clinical and radiological evidence of orbital apex involvement were included in the study. Appropriate medical and surgical intervention were done to each patient. Patients were followed up one-month post intervention. RESULTS: Out of 89 CAM patients, 31(34.8%) had orbital apex syndrome. Sixty-six(74.2%) of such patients had pre-existing diabetes mellitus, 18(58%) patients had prior documented use of steroid use, and 55(61.8%) had no light perception(LP) presenting vision. Blepharoptosis, proptosis, complete ophthalmoplegia were common clinical findings. Seventeen(19.1%) of such patients had variable amount of cavernous sinus involvement. Endoscopic debridement of paranasal sinuses and orbit with or without eyelid sparing limited orbital exenteration was done in most cases, 34(38.2%) patients could retain vision in the affected eye. CONCLUSION: Orbital apex involvement in CAM patients occur very fast. It not only leads to loss of vision but also sacrifice of the eyeball, orbital contents and eyelids. Early diagnosis and prompt intervention can preserve life, vision and spare mutilating surgeries. | Smiti Rani Srivastava Purban Ganguly Debasis Barman Sudip Das Manimoy Bandyopadhyay Asim Kumar Ghosh Subhra Sarkar Amitabha Sengupta Sarbari Swaika Pritam Chatterjee Amit Kumar Gupta Alok Ranjan Mondal Soumyajit Guha Sinjita Dutta Souvik Adhikari Aditi Kaushik Partha Sundar Biswas Asif Ayub | 2022 | International Journal of Ophthalmology(English edition)2022，15，4： | 0 |
| 10 | 为减缓气候变化 能源效率需经济可行显示文摘印度的钢材消耗继续落后于世界上其他国家.为适应经济的发展,到2020年,印度的钢材需求量每年最少为1.5亿~2亿t.当前,印度年钢产量约6 000万t,到2020年,年产量预计将达到2.75亿t.尽管采取有效的工艺可以减少CO2的排放强度,但预计其排放量仍会升高.现有技术存在着经济性与适应性的挑战.例如,干熄焦技术有助于余热的利用,但新建焦炉的成本高是一个障碍,与此同时,现有焦炉也面临着大修的挑战.这些不利之处在大部分余热回收与能源效率项目中始终存在.为保证生产的连续性,关键需要额外的发电能力或配备强劲的电网,这些都与投资相关,因为其常常限制余热回收技术的实施.为紧急应对全球的气候变化,减少CO2排放,正在开发一些新项目.除了从熔渣中回收余热、低温余热资源、碳中性钢冶炼工艺之外,包括碳捕集与贮存也在考虑之列.与电厂锅炉排出的废气相比,高炉荒煤气中含有温度低、含量高的CO2,从中进行碳捕集相对来说更为经济.因此,加快开发与应用高炉的碳捕集与贮存技术具有财务上的激励作用,对印度钢铁业的增长而言,具有可以缓解气候变化的潜力.这些技术的应用在短中期内不利于公司的生存,但为了缓解气候变化和行业长期的可持续性,这些措施势在必行.因此,为保证能及时采用这些技术,总的工作计划需要确保其:①经济上能够承受;②能及时获取;③能够克服技术改造带来的挑战. | Shibojyoti Dutta Amit Agarwal Dillip Kumar Behera 何海良 | 2014 | 世界钢铁2014，，2： | 0 |
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