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| 1 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 2 | The combined effect of photodegradation and stress cracking in polystyrene显示文摘 | A R Sousa K L E Amorim | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
| 3 | Stone fruit injuries and damage at the wholesale market of Sao Paulo Brazil显示文摘 | Amorim L Martins M C Lourenco S A | 2008 | Postharvest Biology and Technology2008，47，： | 1 |
| 4 | Dissecting the routing architecture of self-organizing networks显示文摘 | Amorim M D Sichitiu M L Benbadis F | 2006 | IEEE Wireless Communications2006，13，6： | 1 |
| 5 | IL-13 induces CD34+ ceils isolated from G-CSF mobilized blood to differentiate in vitro into potent antigen presenting cells显示文摘 | Lopez M Amorim L Gane P | 1997 | J Immunol Methods1997，208，2： | 1 |
| 6 | Leukocyte depletion during CPB: effects on inflammation and lung function显示文摘 | Amorim C G Malbouisson L M da S F C | 2014 | In- flammation2014，37，1： | 1 |
| 7 | The Combined Effect of Photo-degradation and Stress Cracking inPolystyrene 显示文摘 | SOUSA A R AMORIM K L MEDEIROS E S | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
| 8 | Effect of Design Geometry on the Thermal Fatigue Strength of Brake Drum Made in Vermicular Cast Iron显示文摘 | Amorim Villani G Lopes L | 2006 | SAE Technical Paper2006，，01： | 1 |
| 9 | Lowering the synthesis temperature of Ni2P/SiOz by palladium addition显示文摘 | da Silva V T Sousa L A Amorim R M | 2011 | J Catal2011，279，1： | 1 |
| 10 | Chemical modification of cross-linked resinbased on acrylonitrile for anchoring metal ions 显示文摘 | de Santa Maria L C Amorim M C V Aguiar M R M P | 2001 | Reactive and Functional Polymers2001，49，2： | 1 |
| 11 | Early changes induced by short-term low-dose cadmium exposure in rat ventral and dorsolateral prostates[J3显示文摘 | Laeorte L M Delella F K Porto Amorim E M | | 0，，11： | 1 |
| 12 | mtDNAphylogeny and evolution of laboratory mouse strains显示文摘 | Goios A Pereira L Bogue M Macaulay V Amorim A | 2007 | Genome Res2007，17，3： | 1 |
| 13 | Admission profilein an obstetrics intensive care unit in a maternity hospital ofbrazil显示文摘 | AMORIM MMR KATZ L AVILA MB | 2006 | Revista Brasileira de Saude Matemo Infantil2006，6，： | 1 |
| 14 | Deeom- pressive craniectomy:a meta-analysis of influences on intracra- nial pressure and cerebral perfusion pressure in the treatment of traumatic brain injury显示文摘 | Bor Seng Shu E Figueiredo E G Amorim R L | 2012 | J Neurosurg2012，117，3： | 1 |
| 15 | Electrochemical degradation of sulfamethoxazole and trimethoprim at boron-doped diamond electrode:Performance,kinetics and reaction pathway显示文摘 | De Amorim K P Romualdo L L Andrade L S | 2013 | Separation and Purification Technology2013，120，： | 1 |
| 16 | Determination of cadmium and lead in table salt by sequential multi-element flame atomic absorption spectrometry显示文摘 | FABIO A C AMORIM SERGIO L C | 2005 | Talanta2005，65，： | 1 |
| 17 | Pros and cons in the use of SNPs in forensic kinship investigation: a comparative analysis with STRs显示文摘 | Amorim A Pereira L | 2005 | Forensic Sci Int2005，150，1： | 1 |
| 18 | Improved hemodynamic parameters in middle cerebral artery infarction after decompressive craniectomy显示文摘 | Amorim R L de Andrade A F Gattás G S | 2014 | Stroke2014，45，5： | 1 |
| 19 | Effects of anterior thalamic nucleus deep brain stimulation in chronic epileptic rats显示文摘 | Covolan L de Almeida AC Amorim B | 2014 | PLoS One2014，9，97： | 1 |
| 20 | Clonal and Antibiotic Resistance Profiles of Methicillirr Resistant Staphylococcus Aureus (MRSA) from a Portuguese Hospital over Time显示文摘 | Amorim M L Aires de Sousa M Sanches I S | 2002 | Microb Drug Resist2002，8，： | 1 |
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