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| 1 | Using the polymerase chain reaction coupled with denaturing gradient gel electrophoresis to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted acute severe pancreatitis显示文摘AIM: To investigate the use of PCR and DGGE to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted severe AP.METHODS: Patients with biochemical and clinical evidence of acute pancreatitis and an APACHE Ⅱ score ≥8 were enrolled. PCR and DGGE were employed to detect bacterial translocation in blood samples collected on d1,3, and 8 after the admission. Standard microbial blood cultures were taken when there was clinical evidence of sepsis or when felt to be clinically indicated by the supervising team.RESULTS: Six patients were included. Of all the patients investigated, only one developed septic complications;the others had uneventful illness. Bacteria were detected using PCR in 4 of the 17 collected blood samples. The patient with sepsis was PCR-positive in two samples (taken on d 1 and 3), despite three negative blood cultures. Using DGGE and specific primers, the bacteria in all blood specimens which tested positive for the presence of bacterial DNA were identified as E coli.CONCLUSION: Our study confirmed thatunlike traditional microbiological techniques, PCR can detect the presence of bacteria in the blood of patients with severe AP. Therefore, this latter method in conjunction with DGGE is potentially an extremely useful tool in predicting septic morbidity and evaluating patients with the disease. Further research using increased numbers of patients, in particular those patients with necrosis and sepsis, is required to assess the reliability of PCR and DGGE in the rapid diagnosis of infection in AP. | Callum B Pearce Vitaly Zinkevich Iwona Beech Viera Funjika Ana Garcia Ruiz Afraa Aladawi Hamish D Duncan | 2005 | World Journal of Gastroenterology2005，11，45： | 11 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 4 | Purification and characterization of prophenoloxidase from the haemolymph of Locusta migratoria 显示文摘 | Anas C Bernard D Michel B | 1996 | Arch Insect Biochem1996，32，： | 1 |
| 5 | Protoplast production from napier grass and pearl millet triploid hybrids 显示文摘 | Ana L O T Lisete C D Jos6 E B P P | 2010 | Scientific Electronic Library Online2010，34，5： | 1 |
| 6 | Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study显示文摘 | Enrique G Gerardo B Ana D | | The Lancet0，350，： | 1 |
| 7 | A spare parts model with cold-standby redundancy on system level 显示文摘 | Karin S S D Nicole P E Ana I B | 2011 | Computers : Operations Research2011，38，7： | 1 |
| 8 | Highly conductive ambient-temperature melten salts显示文摘 | Pierre B T Ana P D Nicho L P R | 1996 | Inorg Chem1996，35，10： | 1 |
| 9 | Polymorphisms in exons 6 and 7 of the ABO locus and their association with venous thrombosis in young Brazilian patients显示文摘 | Sabrina G Paiva Adriano P Sabino Maria G Carvalho Daniel D Ribeiro Karina B Gomes Mariana S Santos Marina S Oliveira Geralda G Lages Luci MS Dusse Ana Paula Fernandes | 2009 | Blood Coagulation & Fibrinolysis2009，，2： | 1 |
| 10 | Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp, in response to the deleterious changes induced by H2O2 显示文摘 | Elena G B Ana I D Maria E C | 2013 | Nat Prod2013，76，5： | 1 |
| 11 | Low-dose adenosine stress echoeardiography: Detection of myocardial viability显示文摘 | Ana D Miodiodrag O Branko B | 2003 | Cardiovascular Ultrasound2003，1，： | 1 |
| 12 | Arabidopsis and tobacco plants ectopically expressing the soybean antiquitin-like ALDH7 gene display enhanced tolerance to drought,salinity,and oxidative stress显示文摘 | Simone M R Maxuel O A Ana P S G Fabio M D Maria C B P Elizabeth P B F | | 0，，： | 1 |
| 13 | The effect of thermal treatment on the properties of sol-gel copper-silica eatalysts显示文摘 | Edesia M B D S Ana P G Nelcy D S | 2001 | Appl Surf Sci2001，183，34： | 1 |
| 14 | The effect of thermal treatment on the properties of sol-gel copper-silica catalysts 显示文摘 | EDESIA M B D S ANA P G NELCY D S | 2001 | Appl Surf Sci2001，183，： | 1 |
| 15 | Intramolecular excited state quenching 5--1,10-phenanthroline,a new donor ligand显示文摘 | Alvaro D Ana M L Bárbara L | 2005 | Polyhedron2005，24，： | 1 |
| 16 | Hydrophobic,highly conductive ambient-temperature molten salts显示文摘 | Pierre B Ana P D | 1996 | Inorg Chem1996，35，： | 1 |
| 17 | Green tea extract as natural antioxidant to extend the shelf-life of fresh-cut lettuce显示文摘 | Ana B Martin D Daniel R | 2008 | Innovative Food Science and Emerging Technologies2008，9，4： | 1 |
| 18 | Spatial and seasonal variations of the macrobenthic community and metal contamination in the Douro estuary (Portugal) 显示文摘 | Ana P M Teresa S D V Adriano A B | 2005 | Marine Environmental Research2005，60，5： | 1 |
| 19 | Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity显示文摘 | FRAGA B M CARMEN E D ANA G | 2005 | J Agric Food Chem2005，53，： | 1 |
| 20 | Evidence for benefits from treating cervical ectopy:Literature review显示文摘 | Luis C M J Ana S W D Heraclito B D C | 2008 | Sao Paulo Med J2008，126，2： | 1 |
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