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| 1 | Microproteinuria in patients with inflammatory bowel disease:Is it associated with the disease activity or the treatment with 5-aminosalicylic acid?显示文摘瞄准:调查在有煽动性的肠疾病(IBD ) 的病人的 microproteinuria 是否与 5-aminosalicylic 酸(5-ASA ) 与疾病活动或治疗被联系。方法:我们有希望地与 IBD 在 86 个连续病人学习了 microproteinuria, 61 与 ulcerative (UC ) 并且 25 与 Crohn 的疾病(CD ) ,以前象在他们在学习的包括以后的 2 和 6 个月一样。46 个病人为 28.8 个月(范围 1-168 瞬间) 的一个时期收到了 5-ASA。Microalbuminuria (妈磅) 和尿肾的管状的蛋白质 beta2-microglobulin (beta2mGLB ) 和 beta-N-acetyl-D-glucosamidase 铺平(贝它 -- 唠叨) 一夜间在 12-h 象 creatinine 一样被决定尿收集。肿瘤坏死 factor-alpha (TNF-alpha ) 浆液层次也被测量。结果:277 大小的一个总数(194 在 UC 病人并且 83 在 CD 病人) 被执行。在 UC 和 CD 病人的反常 microproteinuria 的流行为妈磅是 12.9% 和 6.0% , 22.7% 和 27.7% 为 beta2mGLB,并且 11.3% 和 8.4% 为贝它 -- 分别地唠叨。妈磅没与 IBD 活动被联系。Beta2mGLB 和贝它 -- 唠叨尿层次被相关到 UC 活动(UCAI:P<0.01;UCEI:P<0.005 ) 。在 UC 病人和贝它的妈磅 -- 在 CD 病人唠叨尿层次与 TNF-alpha 浆液层次有关。一个协会在 microproteinuria 和吸烟习惯之间被注意。有 5-ASA 的治疗没被相关到 microproteinuria 的严厉或到 creatinine 的变化。结论:Microproteinuria 主要与 UC 和它的活动被联系然而并非由 5-ASA 影响了。 | Androniki C Poulou Konstantinos E Goumas Dimitrios C Dandakis Ioannis Tyrmpas Maria Panagiotaki Androniki Georgouli Dimitrios C Soutos Athanasios Archimandritis | 2006 | World Journal of Gastroenterology2006，12，5： | 126 |
| 2 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 3 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 4 | Alternative nuclear functions for NF-KB family members显示文摘 | Llufs E Anna B Maria C M | 2011 | Am J Cancer Res2011，1，4： | 1 |
| 5 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 6 | An expeditious method for the determination of organochlorine pesticides residues in estuarine sediments using microwave assisted pre-extraction and automated headspace solid-phase microextraction coupled to gas chromatography-mass spectrometry 显示文摘 | Pedro N C Pedro N R Filipe A Rafael E Maria C P Teresa M V | 2008 | Talanta2008，76，5： | 1 |
| 7 | Genetic diversity of populations of the freshwater shrimp (Macrobrachi-um borellii) eval- uatedby RAPD analysis显示文摘 | Maria E D Daniel C | 1996 | Journal of Crustacean Biol- ogy1996，16，4： | 1 |
| 8 | Cuff-leak test for the diagnosis of upper airway obstruction in adults : a systematic review and meta-analysis 显示文摘 | Mafia E O Maria C M Fernando F V | 2009 | Intensive Care Med2009，35，7： | 1 |
| 9 | Catalytic oxidation of cyclohexane by a binuclear Fe ( Ⅲ ) complex biomimetic to methane monooxygenase显示文摘 | Maria C E Enrique G O Heiddy M A | 2005 | J Inorg Biochem2005，99，： | 1 |
| 10 | Catalytic oxidation of cyclohexane by a binuctear Fe (Ⅲ)complex biomimetic to methane monooxygenase显示文摘 | Maria C E Enrique G O Heiddy M A | 2005 | J Inorg Biochem2005，99，： | 1 |
| 11 | Magnetic silica colloids for catalysis显示文摘 | Maria C E Nilesh M C Robertus K G J M | 2007 | Journal of Magnetism and Magnetic Materials2007，311，： | 1 |
| 12 | Preparation of griseofulvin nanoparticles from water-dilutable microemulsions显示文摘 | Michele T Marina G Maria E C | 2003 | Int J Pharm2003，254，2： | 1 |
| 13 | Influence of sub-lethal antiox- idant doses, water potential and temperature on growth, sclero- tia, aflatoxins and aflD( = nor-1 ) expression by Aspergillus fla- vus RCP08108显示文摘 | Maria A P Laura C R Miriam E | 2012 | Microbiol Res2012，167，8： | 1 |
| 14 | Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp, in response to the deleterious changes induced by H2O2 显示文摘 | Elena G B Ana I D Maria E C | 2013 | Nat Prod2013，76，5： | 1 |
| 15 | The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats显示文摘 | Cátia Lira Do Amaral Rafaela de Barros e Lima Bueno Regislaine Valéria Burim Regina Helena Costa Queiroz Maria de Lourdes Pires Bianchi Lusania Maria Greggi Antunes | 2011 | MutRes-Genetic Toxicology and Environmental Mutagenesis2011，，1： | 1 |
| 16 | Yard stories: examining residents' conceptions of their yards as part of the urban ecosystem in Minnesota显示文摘 | MARIA E D KRISTEN C N | 2014 | Urban Ecosystem2014，，17： | 1 |
| 17 | Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line显示文摘 | Maria C Zatelli Federico Tagliati John E Taylor | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 18 | Serum level of soluble intercellular adhesion molecule 1 in patients with chronic liver disease related to hepatitis C virus:a prognostic marker for responses to interferon treatment显示文摘 | CAPRA F DE MARIA E LUNARDI C | 2000 | J Infect Dis2000，181，： | 1 |
| 19 | Maize kernel composition and post-flowering source-sink ratio显示文摘 | BORRA L JOEE A C MARIA E O | 2002 | Crop Sci2002，42，： | 1 |
| 20 | ^131I SPECT/CT in the fol- low-up of differentiated thyroid carcinoma:incremental value versus planar imaging 显示文摘 | Angela S Maria E Francesca C | 2009 | J Nuc Med2009，50，2： | 1 |
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