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| 1 | Tailoring active compounds across biological membranes by cubosomal technology: an updated review显示文摘It is challenging for many drugs to be transported across various biological membranes. Furthermore, development of many drugs gets thwarted owing to their hydrophilic nature. The bioavailability of such drugs, which is the function of their ability to cross the membrane, tends to be low and exhibit high intra and inter subject variability. At present, formulation scientists are pursuing many projects for transdermal, nasal, target delivery of many active compounds, and it is prudent to explore alternative possibilities. Cubosomes offer transportation and tailoring of active compounds intended for both systemic and dermal delivery. Cubosomes are dispersed, self-assembled nanoparticles of bicontinuous cubic liquid crystalline phase formed from lipid and surfactant systems. Monoolein, poloxamer 407 and polyvinyl alcohol are the mostly used ingredients in the formulation of cubosomes. The adjustment in lipid composition can control the internal and structural changes of cubosomes. Based on the nodal surfaces, three structures of cubosomes proposed are Pn3m, Ia3d and Im3m. Top-down and bottom-up techniques are widely considered in the formulation process of extreme viscous bulk phase and aggregate from a precursor respectively. This article gives a bird's eye view about the engineering, characterization and evaluation of cubosomes, covering researches and applications of cubosomes done till date. | Vinod K.R. Sravya K. Sandhya S. David Banji Anbazhagan S. Prameela Rani A. | 2013 | Journal of Chinese Pharmaceutical Sciences2013，22，4： | 4 |
| 2 | Landslide Hazard Zonation Mapping in Ghat Road Section of Kolli Hills, India显示文摘Landslides are the most common natural disaster in hilly terrain which causes changes in landscape and damage to life and property. The main objective of the present study was to carry out landslide hazard zonation mapping on 1:50,000 scale along ghat road section of Kolli hills using a Landslide Hazard Evaluation Factor(LHEF) rating scheme. The landslide hazard zonation map has been prepared by overlaying the terrain evaluation maps with facet map of the study area. The terrain evaluation maps include lithology, structure, slope morphometry, relative relief, land use and land cover and hydrogeological condition. The LHEF rating scheme and the Total Estimated Hazard(TEHD) were calculated as per the Bureau of Indian Standard(BIS) guidelines(IS: 14496(Part-2) 1998) for the purpose of preparation of Landslide Hazard Zonation(LHZ) map in mountainous terrains. The correction due to triggering factors such as seismicity, rainfall and anthropogenic activities were also incorporated with Total Estimated Hazard to get final corrected TEHD. The landslide hazard zonation map was classified as the high, moderate and low hazard zones along the ghat road section based on corrected TEHD. | Siddan ANBAZHAGAN Veerappan RAMESH | 2014 | Journal of Mountain Science2014，11，5： | 3 |
| 3 | Seroprevalence of HCV and its co-infection with HBV and HIV among liver disease patients of South Tamil Nadu显示文摘AIM:To determine the seroprevalence of hepatitis C virus(HCV) and its co-infection with hepatitis B virus(HBV),hepatitis delta agent(HDV) and human immunodeficiency virus(HIV) among liver disease patients of south Tamil Nadu. METHODS:A total of 1012 samples comprising 512 clinically diagnosed cases of liver disease patients and 500 apparently healthy age and sex matched individuals were screened for Hepatitis C virus(anti HCV and HCV RNA) ,Hepatitis B virus(HBsAg),Hepatitis delta agent(anti HDV) and Human immuno virus(antibodies to HIV-1 and HIV-2) using commercially available enzyme linked immunosorbent assay kits.HCV RNA wasdetected by RT-PCR.Liver function tests like ALT,AST,GGT,ALP,bilirubin and albumin were also studied. RESULTS:The seroprevalence of HCV was found to be 5.6%among liver disease patients by ELISA.27/512,49/512 and 12/512 patients were positive for HIV,HBV &HDV respectively.Co-infection of HCV&HBV was found in 8 patients,with 6 for HCV&HIV and 4 for HCV,HBV&HIV co-infections.Sex-wise analysis showed that HIV,HCV&HBV and HCV&HIV co-infection was high among females whereas for HBV it was high in males. The mean ALT and AST in HCV positive cases were 42.1±8.3 and 49±10.1.In people co-infected with HCV&HBV or HCV&HIV or HCV,HBV&HIV the mean ALT of 58.0±03.16,56.78±4.401 and 64.37±4.01 respectively. CONCLUSION:We strongly recommend routine test of the blood for HCV in addition to HBV and HIV.We also recommend individualized counseling to identify those at risk and testing for those who want it.Improved surveillance and periodic epidemiological studies will have to be undertaken to monitor and prevent these blood-borne viruses. | Ganesh Kumar Anbazhagan Sridharan Krishnamoorthy Thirunalasundari Thiyagarajan | 2010 | World Journal of Hepatology2010，2，1： | 2 |
| 4 | Production oftransgenic Aralia elata regenerated from Agrobacterium rhizogenesmediatedtransformed roots显示文摘 | Kang H J Anbazhagan V R You X L | 2006 | Plant Cell Tissue and Organ Culture2006，85，： | 1 |
| 5 | GeographicInformation Systemandgrou ndwaterqualitymap pinginPanvelBasin,Maharashtra,India显示文摘 | AnbazhaganS NairAM | | 0，，06： | 1 |
| 6 | Analysis of polymorphism in renin angiotensin system and other related genes in South Indian chronic kidney disease patients显示文摘 | Anbazhagan K Sampathkumar K Ramakrishnan M | 2009 | Clin Chim Acta2009，406，： | 1 |
| 7 | Critical is- sues related to transfersomes-novel vesicular system 显示文摘 | Vinod KR Kumar MS Anbazhagan S | 2012 | Acta Sci Pol TechnolAliment2012，11，1： | 1 |
| 8 | Agrobacteriura mediated genetic transformationnand development of herbicideresistant sugarcane(Saccharum species hybieds)using axillany buds显示文摘 | Manickavasagam M Ganapathi A Anbazhagan V R | 2004 | Plant Cell Rep2004，23，3： | 1 |
| 9 | Analysis of polymorphism in renin angiotensin system and other related genes in South Indian chronic kidney disease patients显示文摘 | Anbazhagan K Sampathkumar K Ramakrishnan M | 2009 | Clin Chim Acta2009，406，12： | 1 |
| 10 | Evolutionary a- nalysis of PHLPPl gene in humans and non - human primates 显示文摘 | Anbazhagan P Purushottam M Kumar HB | 2008 | Bioinformation2008，2，10： | 1 |
| 11 | Polyphenol-rich pomegranate fruit extract(POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP kinases and NF-κB in human KU812 cells显示文摘 | Zafar Rasheed Nahid Akhtar Arivarasu N Anbazhagan | 2009 | J Inflam2009，6，1： | 1 |
| 12 | Contention based bandwidth request with signaling analysis in IEEE 802.16 two hop relay networks显示文摘 | Anbazhagan Rajesh Rangaswamy Nakkeeran | 2012 | Computers and Electrical Engineering2012，，： | 1 |
| 13 | MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in humanos- teoarthritis chondrocytes 显示文摘 | Akhtar N Rasheed Z Ramamurthy S Anbazhagan A N Voss F R Haqqi T M | 2010 | Arthritis Rheum2010，62，： | 1 |
| 14 | Interaction of meso-tetrakis (p-sulfonatophenyl)porphyrin (TSPP) with pyrimidines:A steady state and time-resolved fluorescence quenching study显示文摘 | Kathiravan A Anbazhagan V Jhonsi M A | | 0，，1： | 1 |
| 15 | Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product induced-expression of tumor necrosis factor-α and matrix metallo -proteinase -13 in human Chondrocytes显示文摘 | Zafar Rasheed Arivarasu N Anbazhagan | 2009 | Arthritis Research & Therapy2009，11，： | 1 |
| 16 | Allelie loss of chromosomal arm 8p in breast cancer progression 显示文摘 | Anbazhagan R Fujii H Gabrielson E | 1998 | Am J Pathol1998，152，： | 1 |
| 17 | Laboratory Characterization of Tyre Crumbs Soil Mixture for Developing Low Cost Damping Materials显示文摘 | Anbazhagan P Mamatha M Soumyashree P | 2011 | Intemational Journal of Earth Sciences and Engineering2011，4，6： | 1 |
| 18 | Allelic loss of chromosomal arm Spin breast cancer progression显示文摘 | Anbazhagan R Fujii H Gabrielson E | 1998 | AmJ Pathol1998，152，3： | 1 |
| 19 | Heterologous expression of oxalate decarboxylase in Lactobacillus plantarum NCS显示文摘 | Anbazhagan K Leema G Selvam S | 2009 | CurrMicrobiol2009，58，： | 1 |
| 20 | Laboratory Characterization of Tyre Crumbs Soil Mixture for Developing Low Cost Damping Materials显示文摘 | Anbazhagan P Mamatha M Soumyashree P | 2011 | International Journal of Earth Sciences and Engineering2011，4，6： | 1 |
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