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| 1 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 2 | No increased risk of developing Alzheimer diseasein patients with glaucoma显示文摘 | Kessing LV Lopez AG Andersen PK | 2007 | J Glaucoma2007，16，1： | 1 |
| 3 | Coaggregation of Fusobacterium nucleatum,Selenomonas flueggei,Selenomonas infelix,Selenomonas noxia,and Selenomonas sputigena with strains from 11 genera of oral bacteria显示文摘 | Kolenbrander PE Andersen RN Moore LV | 1989 | Infect Immun1989，57，10： | 1 |
| 4 | Atrial fibrillation and upper limb thromboembolectomy: a national cohort study显示文摘 | Andersen LV Mortensen LS Lip GY | 2011 | J Thromb Haemost2011，9，： | 1 |
| 5 | A novel liposomal adjuvant system, CAFE, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human 显示文摘 | van Dissel JT Joosten SA Hoff ST Soonawala D Prins C Hokey DA O'Dee DM Graves A Thierry-Carstensen B Andreasen LV Ruhwald M de Visser AW Agger EM Ottenhoff TH Kromann I Andersen P | 2014 | Vaccine2014，32，52： | 1 |
| 6 | Clonal analysis of the Actinobacillus pleuropneumoniae population in a geographic, ally restricted area by multilocus enzyme electrophoresis显示文摘 | Moller K Nielsen R Andersen LV | 1992 | J Clin Microbiol1992，30，3： | 1 |
| 7 | Coaggregation of Fusobacterium nucleatum, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomohas sputigena with strains from 11 genera of oral bacteria显示文摘 | Kolenbrander PE Andersen RN Moore LV | 1989 | Infect Immun1989，57，10： | 1 |
| 8 | Upper-limb thrombo-embolectomy: national cohort study in denmark 显示文摘 | Andersen LV Mortensen LS Lindholtc JS | 2010 | Eur J Vase Endovasc Surg2010，40，5： | 1 |
| 9 | Randomized double-blind comparison of tolfenamic acid and paracetamol in migraine显示文摘 | Larsen BH Christiansen LV Andersen B | 1990 | Acta Neurol Scand1990，81，5： | 1 |
| 10 | Coaggregation of Fusobocterium nucleatztm, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomohas sputigena with strains from 11 genera of oral bacteria显示文摘 | Kolenbrander PE Andersen RN Moore LV | 1989 | Infect Immun1989，57，10： | 1 |
| 11 | Coaggregation of oral bacteroide species with other bacteria: central role in coaggregation bridges and competitions 显示文摘 | Kolenbrander PE Andersen RN Holdeman LV | 1985 | Infec Immunol1985，48，3： | 1 |
| 12 | The impact of cognitive impairment on short-term outcomes of hip fracture patients 显示文摘 | Moncada LV Andersen RE Franckowiak SC | 2006 | Arch Gerontol Geriatr2006，43，1： | 1 |
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