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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 3 | Evolution of pore solution chemistry, electro-osmosis and rehar corrosion rate induced by realkalisation显示文摘 | ANDRADE C CASTELLOTE M SARRIA J | 1999 | Materials and Structures1999，32，220： | 1 |
| 4 | 显示文摘 | Lima M D de Andrade M J Bergmann C P | 2008 | J Mater Chem2008，18，： | 1 |
| 5 | Chemical composition of lipophilic extractives from jute (Corchorus capsularis)fibers used for manufacturing of high-quality paper pulps 显示文摘 | Rio Andrade J C Marques G Rodriguez Garcia M I | 2009 | Industrial Crops and Products2009，30，： | 1 |
| 6 | A dose response study following in utero and lactational exposure to di-(2-ethylhexyl)phthalate(DEHP):Reproductive effects on adult male offspring rats显示文摘 | Andrade A J M Grande S W Talsness C E | | 0，，01： | 1 |
| 7 | Effects of tillage method and crop rotation on the population sizes and diversity of bradyrhizobia nodulating soybean显示文摘 | FERREIRA M C ANDRADE D S CHUEIRE L M O | 2000 | Soil Biology Biochemistry2000，32，： | 1 |
| 8 | Hydrothermal nucleation of hydroxyapatite on titanium surface 显示文摘 | ANDRADE M C FILGUEIRAS M R T OGASAWARA T | 2002 | J Eur Ceram Soc2002，22，： | 1 |
| 9 | An Interactive Algorithm for Image Smoothing and Segmentation显示文摘 | M C DE ANDRADE | 2004 | Electronic Letters on Computer Vision and Image Analysis2004，4，1： | 1 |
| 10 | Advancements in non-destructive control of efficien- cy of electrochemical repair techniques 显示文摘 | MARTINEZ I ANDRADE C CASTELLOTE M | 2009 | Corrosion Engineering Science and Technology2009，44，2： | 1 |
| 11 | Bench-to-bedside review:sepsis-from the redox point of view显示文摘 | Andrades M(E) Morina A Spasi(c) S | | 0，，： | 1 |
| 12 | Ab initio molecular dynamics simulation of hydrogen diffusion in a-iron显示文摘 | SanchezJ FulleaJ Andrade M C | 2010 | Physical Review B2010，81，13： | 1 |
| 13 | Activity Based Costing For Production Learning显示文摘 | Pessanha Filho R C Espozel etc | 1999 | Int J Production Economics1999，，62： | 1 |
| 14 | Purification process of stevioside using zeolites and membranes显示文摘 | SILVA F V BERGAMASCO R ANDRADE C M G | 2007 | International Journal of Chemical Reactor Engineering2007，5，1： | 1 |
| 15 | Efficiency of different clay minerals modified with a eationic surfactant in the adsorption of pesticides: influence of clay type and pesticide hydrophobie 显示文摘 | SANCHEZ M M J RODRIGUEZ C M S ANDRADES M S | 2006 | Applied Clay Science2006，31，34： | 1 |
| 16 | An- tioxidant, a pro - oxidant and cytotoxic effects of achy- rocline satureioides extracts显示文摘 | Polydoro M De Souza K C Andrades M E | 2004 | Life Sciences2004，74，： | 1 |
| 17 | Production of 1,3-propanediol by Clostridium butyrieum VPI 3266 using a synthetic medium and raw glycerol 显示文摘 | Gonza'lez Pajuelo M Andrade J C Vaseoncelos I | 2004 | J Ind Microbial Biotechnol2004，31，9： | 1 |
| 18 | Catalytic Effect of Magnetic Nanoparticles Over the H202 Decomposition Reaction显示文摘 | Andrade A L Souza D M Pereira M C | 2009 | J NanosciNanotechnol2009，9，5： | 1 |
| 19 | Clarification and purification of aqueous Stevia extract using membrane separation process 显示文摘 | REIS M H M SILVA F V ANDRADE C M G | 2009 | Journal of Food Process Engineering2009，32，3： | 1 |
| 20 | The early responses of VEGF and its receptors during acute lung injury:implication of VEGF in alveolar epithelial cell survival显示文摘 | Mura M Him B Andrade C F | 2006 | Critical Care2006，10，5： | 1 |
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