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1篇 您的检索式：作者名="Anika Trautmann"

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		题名	作者	年代	出处	被引量
	1	Towards a versatile point-of-care systemcombining femtosecond laser generatedmicrofluidic channels and direct laserwritten microneedle arrays显示文摘Microneedle-based microfluidic systems have a great potential to become well-accepted medical devices for simple,accurate,and painless drug delivery and lab-on-a-chip diagnostics.In this work,we report on a novel hybrid approach combining femtosecond direct laser written microneedles with femtosecond laser generated microfluidic channels providing an important step towards versatile medical point-of-care systems.Hollow microneedle arrays are fabricated by a laser system designed for two-photon polymerization applications.Compression tests of two different types of truncated cone-shaped microneedle arrays prepared from OrmoComp^(■)give information about the microneedle mechanical strength,and the results are compared to skin insertion forces.Three-dimensional microchannels are directly created inside PMMA bulk material by an ultrashort pulse laser system with vertical channels having adjustable cross-sectional areas,which allow attaching of microneedles to the microfluidic system.A comprehensive parameter study varying pulse duration and repetition rate is performed on two-photon polymerization to identify an optimal laser power range for fabricating microneedles using the same pulse duration and repetition rate as for microchannels.This addresses the advantage of a single laser system process that overcomes complex fabrication methods.A proof of concept flow test with a rhodamine B dye solution in distilled water demonstrates that the combination of microneedles and microchannels qualifies for microfluidic injection and extraction applications.	Anika Trautmann Gian-Luca Roth Benedikt Nujiqi Thomas Walther Ralf Hellmann	2019	Microsystems & Nanoengineering2019，5，1：	3

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