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| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | Photochemical synthesis of gold nanoparticles via controlled nucleation using a bioactive molecule 显示文摘 | Anjali P | 2004 | Mater Lett2004，58，： | 1 |
| 3 | Combination Angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice显示文摘 | Scappaticci RS Anjali P | 2001 | Molecular Therapy2001，2，： | 1 |
| 4 | Synthesis,characterization and catalytic activity of new solid acid catalysts ,H3PW12O40 supported on to hydrous zirconia 显示文摘 | Shirish P Nipa P Anjali P | 2003 | Journal of Molecular Catalysis A: Chemical2003，192，： | 1 |
| 5 | A review on natural image denoi- sing using independent component analysis ( ICA ) technique 显示文摘 | ANJALI P A JAY S SAPRE S D | 2010 | Advances in Computational Research2010，2，1： | 1 |
| 6 | Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V 显示文摘 | Jisong C Kuso O Anjali P | 1996 | Nature1996，384，： | 1 |
| 7 | Momordica charantia (bitter gourd)peel, pulp, seed and whole fruit extract inhibits mouse skin papillomagenesis 显示文摘 | Anjali S Satya S P Ramesh B | 1998 | Toxicology Letters1998，94，： | 1 |
| 8 | Silver nanoparticlecatalyzed reduction of aromatic nitrocompounds 显示文摘 | NARAYAN P ANJALI P TARASANKAR P | 2002 | Colloid SurfA-Physicochem Eng Asp2002，196，： | 1 |
| 9 | Photoinitiated gold sol generation in aqueous Triton X-100 and its analytical application for spectrophotometricdetermination of gold显示文摘 | Anjali P | 1998 | Talanta1998，46，4： | 1 |
| 10 | Efficient synthesis of biodiesel from waste cooking oil using solid acid catalyst com- prising 12-tungstosilicic acid and SBA-15显示文摘 | NILESH N VARSHA B ANJALI P | 2014 | Fuel2014，135，： | 1 |
| 11 | 12-Tungstophosphoric acid anchored to SBA-15: An efficient, environmentally benign reusable catalysts for biodieselproduction by esterification of free fatty acids显示文摘 | VARSHA B ANJALI P | 2011 | Applied Catalysis A: General2011，403，： | 1 |
| 12 | 12 - Tungstophosphoric acid anchored to SBA-15: An efficient, environmentally benign reusable catalysts forbiodiesel production by esterification of free fatty acids 显示文摘 | Varsha B Anjali P | 2011 | Ap-plied Catalysis A2011，403，12： | 1 |
| 13 | Synthesis, characterization and crystal density modeling of four C24H28 eage-funct ionalized alkenes 显示文摘 | Alan P M Anjali Z Florencio Z | 1994 | Tetrahedron1994，50，6： | 1 |
| 14 | Endothelial Notch activity promotes angiogenesis and osteogenesis in bone显示文摘 | Saravana K Ramasamy Anjali P Kusumbe Lin Wang | 2014 | Nature2014，507，7492： | 1 |
| 15 | Anilinc as a stabilizer for metal nanoparticlcs显示文摘 | Anjali A Athawale Bhagwat S V Prachi P Katre | 2003 | Materials Letters2003，57，： | 1 |
| 16 | Fabrication of highly porous conducting PANi-C composite fiber mats via electrospinning显示文摘 | SUJITH K ASHA A M ANJALI P | 2012 | Materials Letters2012，67，1： | 1 |
| 17 | Synthesis, characterization and crystal density modeling of four C24H28 cage-functionalized alkenes显示文摘 | Anjali Z Florencio Z | 1994 | Tetrahedron1994，50，6： | 1 |
| 18 | Effects of chemical reaction heat and mass transfer on MHD flow past a semi infinite plate显示文摘 | Anjali Devi S P Kandaswamy R | 2000 | ZAMM2000，80，10： | 1 |
| 19 | Production by esterification of free fatty acid over sulfated zirconia显示文摘 | ANJALI P VARSHA B NNMITA S | 2013 | Renewable Energy2013，，51： | 1 |
| 20 | Photochemical synthesis of gold nanoparticles via controlled nucleation using a bioactive molecule 显示文摘 | Anjali P | 2004 | Materials Letters2004，58，： | 1 |
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