|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases显示文摘Cardiometabolic disease(CMD), characterized with metabolic disorder triggered cardiovascular events, is a leading cause of death and disability. Metabolic disorders trigger chronic low-grade inflammation, and actually, a new concept of metaflammation has been proposed to define the state of metabolism connected with immunological adaptations. Amongst the continuously increased list of systemic metabolites in regulation of immune system, bile acids(BAs) represent a distinct class of metabolites implicated in the whole process of CMD development because of its multifaceted roles in shaping systemic immunometabolism. BAs can directly modulate the immune system by either boosting or inhibiting inflammatory responses via diverse mechanisms. Moreover, BAs are key determinants in maintaining the dynamic communication between the host and microbiota. Importantly, BAs via targeting Farnesoid X receptor(FXR) and diverse other nuclear receptors play key roles in regulating metabolic homeostasis of lipids, glucose, and amino acids. Moreover, BAs axis per se is susceptible to inflammatory and metabolic intervention, and thereby BAs axis may constitute a reciprocal regulatory loop in metaflammation. We thus propose that BAs axis represents a core coordinator in integrating systemic immunometabolism implicated in the process of CMD. We provide an updated summary and an intensive discussion about how BAs shape both the innate and adaptive immune system, and how BAs axis function as a core coordinator in integrating metabolic disorder to chronic inflammation in conditions of CMD. | Baoyi Guan Jinlin Tong Haiping Hao Zhixu Yang Keji Chen Hao Xu Anlu Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 7 |
| 2 | Influence of Curing Accelerators on the Imidization of Polyamic Acids and Properties of Polyimide Films显示文摘In order to lower the imidization temperature of polyamic acids(PAA), the catalytic activities of the curing agents p-hydroxybenzoic acid(PHA), quinoline(QL), benzimidazole(BI), benzotriazole(BTA), triethylamine(Et_3N) and 1, 8-diazabicyclo [5.4.0]undec-7-ene(DBU) were investigated in the process of thermal imidization of PAA. In addition, the effect of these various curing agents on the thermal stabilities and mechanical properties of the resultant polyimide(PI) films was determined. Quinoline was found to be an effective curing accelerator in the use of two-step method for synthesizing PI. Due to its moderate base strength, low steric crowding effect and moderate boiling point, quinoline could not only accelerate PAA to achieve imidization completely at 180 ℃, but also maintain the mechanical properties and thermal stability of the ordinary PI film. Any residual quinoline could be removed from PI films by heating at 250 ℃ for 4 h. | 徐勇 ZHAO Anlu WANG Xinlong XUE Hui LIU Feilong | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 3 |
| 3 | Effects of 1,25-(OH)_2D_3 on Stimulation of Osteoclast-like Cells Formationand Expression of ODF mRNA in Murine Marrow Cells in Vitro显示文摘目的 :观察不同浓度的 1,2 5 - (OH) 2 D3 对破骨细胞形成及对骨髓细胞ODFmRNA表达的影响。进一步阐明骨吸收刺激因子在正畸牙周组织改建中的作用。方法 :应用不同浓度的 1,2 5 - (OH) 2 D3 (0、10 -10 、10 -8、10 -6mol/L)诱导大鼠骨髓细胞破骨样细胞的形成 ,采用体外破骨细胞溶骨模型 ,观察牙本质片上骨吸收陷窝数目 ,采用原位杂交技术检测骨髓基质细胞ODF的mRNA表达。结果 :随着 1,2 5 - (OH) 2 D3 浓度的增加 ,骨陷窝数明显增多 ,陷窝面积增大 ;ODFmRNA表达的阳性信号显著增强。结论 :在体外 ,1,2 5 - (OH) 2 D3 可以调节破骨细胞的骨吸收活性 。 | WANG Feng LIN Zhui LI Yong-ruing YU ANLu | 2004 | 口腔医学研究2004，20，4： | 1 |
| 4 | Performance Evaluation of Land Use Regulation显示文摘This article makes a quantitative study on economic performance of arable land protection and land use regulation with dummy variable model.It is shown that land use regulation is favorable for economic growth and protection of arable land and that there are still some problems in the implementation of land use regulation.Thus,it puts forward corresponding suggestion. | Wang Yumeng Wu Juan Fang Lingli Zhang Anlu | 2010 | Chinese Journal of Population,Resources and Environment2010，8，1： | 0 |
| 5 | Review on the Theory of Ecological Environment Damage Assessment显示文摘In the rapid industrialization and urbanization of China,the damage of ecological environment hinders the people's pursuit of good environmental quality.As a technical means of ecological environment protection,the assessment of ecological environment damage has been attached great importance by all walks of life.However,there are still some problems in the current practice of environmental damage assessment.Therefore,based on the understanding of ecological environment damage assessment and related concepts,this study systematically studies the theory of ecological environment damage assessment.Based on the research,it can be seen that the assessment of ecological environment damage is the inevitable product of social and economic development and the promotion of environmental protection awareness,and ecological environment damage belongs to the subordinate concept of'environmental damage'.The assessment of ecological environment damage includes the assessment of ecological damage and environmental damage,paying attention to the interests of human society and the unclaimed pure environment and pure ecological damage.The assessment of ecological environmental damage determines the goal and direction for the construction of environmental damage compensation system.This study enriches the theory of environmental damage assessment and provides theoretical reference and method basis for environmental damage assessment. | Bin YANG Fei ZHANG Xue WANG Anlu LONG Lingli RAO Yunyan LIU | 2022 | Meteorological and Environmental Research2022，13，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员