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3篇 您的检索式：作者名="Anna S Gukovskaya"

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		题名	作者	年代	出处	被引量
	1	Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB.	Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya	2008	World Journal of Gastroenterology2008，14，23：	30
	2	Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis显示文摘	Mareninova Olga A Hermann Kip French Samuel W O’Konski Mark S Pandol Stephen J Webster Paul Erickson Ann H Katunuma Nobuhiko Gorelick Fred S Gukovsky Ilya Gukovskaya Anna S	2009	Journal of Clinical Investigation2009，，11：	1
	3	Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways显示文摘	Eva C Vaquero Mouad Edderkaoui Kyung J Nam Ilya Gukovsky Stephen J Pandol Anna S Gukovskaya	2003	Gastroenterology2003，，4：	1

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