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| 1 | Nat Microbiol:已结首次构建出小鼠肠道微生物组数据库显示文摘小鼠模型通常被广泛用于药理学和医学研究。我们都知道小鼠肠道中的微生物群落通常会对研究结果产生明显的影响,然而目前研究者们并没有获取到关于小鼠肠道中栖息细菌群落的详细信息。近日刊登在国际杂志Nature Microbiology上的一篇研究报告中。德国慕尼黑理工大学的研究者通过研究首次收集到了小鼠肠道中的多种细菌群落。同时研究者还对其进行了分裂、特性分析。最后得到了100种细菌,其中还包括15种迄今为止未知的细菌群落。 | Lu, Qiulun Yao, Yufeng Hu, Zhenkun Hu, Changqing Song, Qixue Ye, Jian Xu, Chengqi Wang, Annabel Z. Chen, Qiuyun Wang, Qing Kenneth | 2016 | 现代生物医学进展2016，16，32： | 13 |
| 2 | Kinetic study of phytotoxicity induced by foliar lead uptake for vegetables exposed to fine particles and implications for sustainable urban agriculture显示文摘At the global scale, foliar metal transfer occurs for consumed vegetables cultivated in numerous urban or industrial areas with a polluted atmosphere. However, the kinetics of metal uptake, translocation and involved phytotoxicity was never jointly studied with vegetables exposed to micronic and sub-micronic particles(PM). Different leafy vegetables(lettuces and cabbages) cultivated in RHIZOtest? devices were, therefore, exposed in a greenhouse for 5, 10 and 15 days to various Pb O PM doses. The kinetics of transfer and phytotoxicity was assessed in relation to lead concentration and exposure duration. A significant Pb accumulation in leaves(up to 7392 mg/kg dry weight(DW) in lettuce) with translocation to roots was observed. Lead foliar exposure resulted in significant phytotoxicity, lipid composition change, a decrease of plant shoot growth(up to 68.2% in lettuce) and net photosynthesis(up to 58% in lettuce). The phytotoxicity results indicated plant adaptation to Pb and a higher sensitivity of lettuce in comparison with cabbage. Air quality needs, therefore, to be considered for the health and quality of vegetables grown in polluted areas, such as certain megacities(in China, Pakistan, Europe, etc.) and furthermore, to assess the health risks associated with their consumption. | TianTian Xiong Annabelle Austruy Antoine Pierart Muhammad Shahid Eva Schreck Stéphane Mombo Camille Dumat | 2016 | Journal of Environmental Sciences2016，28，8： | 10 |
| 3 | 城市化对趵突泉泉域降水入渗补给的影响显示文摘为研究济南城市化发展对大气降水入渗补给的影响,利用济南市1980、1990、2000、2018年的遥感数据和Feflow软件识别不同时段的趵突泉泉域大气降水入渗补给量,分析城市化发展引起的土地利用类型变化对趵突泉泉域降水入渗补给量的影响。结果表明:1980-2018年,研究区耕地和林地面积显著减少,建设用地面积大幅增加;2000-2018年,研究区不透水面积增加了213.13km^2,大气降水入渗补给量减少了2625万m^3。研究成果可为济南市未来的城区规划提供科学的参考,也为济南保泉供水工作提供有效的数据支撑。 | 倪寒茜 束龙仓 韩刚 张曼琦 王鑫 王小博 余亚飞 OPOKU Portia Annabelle | 2020 | 南水北调与水利科技(中英文)2020，18，6： | 5 |
| 4 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 5 | 熔盐电解精炼提纯金属硅(英文)显示文摘对熔盐电解质中硅的沉积过程进行电化学研究。在 973~223K,在硅氯化物熔盐中采用电解精炼提纯金属硅。结果表明,液态硅铜合金阳极有利于 CaCl2-NaCl-CaO-Si 熔盐体系的电解精炼。ICP-AES 分析结果显示,通过电解精炼可有效去除原料中大量的钛、铝、铁等金属杂质,硅中的硼和磷含量分别由 36×106和 25×106降低至 4.6×10 6和 2.8×10 6,电解能耗约为 9.3 kW·h/kg。 | 蔡靖 罗学涛 卢成浩 Geir Martin HAARBERG Annabelle LAURENT Ole Edvard KONGSTEIN 王淑兰 | 2012 | Transactions of Nonferrous Metals Society of China2012，22，12： | 4 |
| 6 | A demonstration project of Global Alliance against Chronic Respiratory Diseases:Prediction of interactions between air pollution and allergen exposure—the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach显示文摘This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers.For decades,information available for the patients and allergologists consisted of pollen counts,which are vital but insufficient.New technology paves the way to substantial increase in amount and diversity of the data.This paper reviews old and newly suggested methods to predict pollen and air pollutant concentrations in the air and proposes an allergy risk concept,which combines the pollen and pollution information and transforms it into a qualitative risk index.This new index is available in an app(Mobile Airways Sentinel NetworK-air)that was developed in the frame of the European Union grant Impact of Air POLLution on sleep,Asthma and Rhinitis(a project of European Institute of Innovation and Technology-Health).On-going transformation of the pollen allergy information support is based on new technological solutions for pollen and air quality monitoring and predictions.The new information-technology and artificial-intelligence-based solutions help to convert this information into easy-to-use services for both medical practitioners and allergy sufferers. | Mikhail Sofiev Yuliia Palamarchuk Annabelle Bedard Xavier Basagana Josep M.Anto Rostislav Kouznetsov Rodrigo Delgado Urzua Karl Christian Bergmann Joao A.Fonseca Govert De Vries Michiel Van Erd Isabella Annesi-Maesano Daniel Laune Jean Louis Pepin Ingrid Jullian-Desayes Stephane Zeng Wienczyslawa Czarlewski Jean Bousquet | 2020 | Chinese Medical Journal2020，，13： | 3 |
| 7 | The N-terminal Pro-BNP Investigation of Dyspnea in the Emergency department (PRIDE) study显示文摘 | James L. Januzzi Carlos A. Camargo Saif Anwaruddin Aaron L. Baggish Annabel A. Chen Daniel G. Krauser Roderick Tung Renee Cameron J. Tobias Nagurney Claudia U. Chae Donald M. Lloyd-Jones David F. Brown Stacy Foran-Melanson Patrick M. Sluss Elizabeth Lee-L | 2005 | The American Journal of Cardiology2005，，8： | 3 |
| 8 | Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications显示文摘Autosomal dominant osteopetrosis type 2 (ADO2) is a high-density brittle bone disease characterized by bone pain,multiple fractures and skeletal-related events,including nerve compression syndrome and hematological failure.We demonstrated that in mice carrying the heterozygous Clcn7^G213R mutation,whose human mutant homolog CLCN7^G215R affects patients,the clinical impacts of ADO2 extend beyond the skeleton,affecting several other organs.The hallmark of the extra-skeletal alterations is a consistent perivascular fibrosis,associated with high numbers of macrophages and lymphoid infiltrates.Fragmented clinical information in a small cohort of patients confirms extra-skeletal alterations consistent with a systemic disease,in line with the observation that the CLCN7 gene is expressed in many organs.ADO2 mice also show anxiety and depression and their brains exhibit not only perivascular fibrosis but also β-amyloid accumulation and astrogliosis,suggesting the involvement of the nervous system in the pathogenesis of the ADO2 extra-skeletal alterations.Extra-skeletal organs share a similar cellular pathology,confirmed also in vitro in bone marrow mononuclear cells and osteoclasts,characterized by an impairment of the exit pathway of the Clcn7 protein product,ClC7,through the Golgi,with consequent reduced ClC7 expression in late endosomes and lysosomes,associated with high vesicular pH and accumulation of autophagosome markers.Finally,an experimental siRNA therapy,previously proven to counteract the bone phenotype,also improves the extra-skeletal alterations.These results could have important clinical implications,supporting the notion that a systematic evaluation of ADO2 patients for extra-skeletal symptoms could help improve their diagnosis,clinical management,and therapeutic options. | Antonio Maurizi Mattia Capulli Annabel Curle Rajvi Patel Argia Ucci Juliana Alves Cotes Harriet Oxford Shireen R. Lamandé John F. Bateman Nadia Rucci Anna Teti | 2019 | Bone Research2019，7，2： | 3 |
| 9 | Induced Deactivation of Genes Encoding Chlorophyll Biosynthesis Enzymes Disentangles Tetrapyrrole- Mediated Retrograde Signaling显示文摘在光合的有机体,调停 tetrapyrrole 后退信号被建议在叶绿体响应新陈代谢的活动贡献平衡原子 geneexpression (NGE ) 。我们跟随了一条试验性的短期的途径对修改 NGE 的那个 allowedthe 评价 tetrapyrrolebiosynthesis 在 Mg 的明确地修改的酶的步骤的第一个小时期间分叉,当另外的信号的多种的效果能被避免时。响应编码 Mg chelatase, Mg protoporphyrin methyltransferase 和 Mg protoporphyrin monomethylestercyclase 的 CHLH 子单元的 CHLH, CHLM,和 CHL27 的 24-h-induced silencing,分别地,撤销的基因表示很快导致了相应的酶和 alteredMg 卟啉层次的减少的活动。但是 NGE 实质地没被改变。这三基因什么时候连续地在 to4 d 上面被使失去活性为,原子基因的抄本层次的变化被决定。为在坏死的叶损害和调制抄本的超过 24h 结果的 CHL27 silencing 氧化 stress-responsiveand 铺平联系光合作用的原子基因(PhANGs ) 。CHLH 和 CHLM 的延长释放导致 PhANGs 和联系 tetrapyrrole 的基因的稍微提高的抄本层次。为 NGE 上的 tetrapyrrole 生合成的贡献的这些解决时间的研究 indicatea 建筑群情形由 1 O 2-induced 发信号和调整反馈的翼 synthesis.Key 词: | Hagen Schlicke Annabel Salinas Hartwig Vivien Firtzlaff Andreas S. Richter , Christine Glasser Klaus Maier Iris Finkemeier Bernhard Grimm | 2014 | Molecular Plant2014，7，7： | 3 |
| 10 | Exercise interventions for older adults: A systematic review of meta-analyses显示文摘Background:The evidence concerning which physical exercise characteristics are most effective for older adults is fragmented.We aimed to characterize the extent of this diversity and inconsistency and identify future directions for research by undertaking a systematic review of metaanalyses of exercise interventions in older adults.Methods:We searched the Cochrane Database of Systematic Reviews,PsycInfo,MEDLINE,Embase,CINAHL,AMED,SPORTDiscus,and Web of Science for articles that met the following criteria:(1)meta-analyses that synthesized measures of improvement(e.g.,effect sizes)on any outcome identified in studies of exercise interventions;(2)participants in the studies meta-analyzed were adults aged 65+or had a mean age of 70+;(3)meta-analyses that included studies of any type of exercise,including its duration,frequency,intensity,and mode of delivery;(4)interventions that included multiple components(e.g.,exercise and cognitive stimulation),with effect sizes that were computed separately for the exercise component;and(5)meta-analyses that were published in any year or language.The characteristics of the reviews,of the interventions,and of the parameters improved through exercise were reported through narrative synthesis.Identification of the interventions linked to the largest improvements was carried out by identifying the highest values for improvement recorded across the reviews.The study included 56 meta-analyses that were heterogeneous in relation to population,sample size,settings,outcomes,and intervention characteristics.Results:The largest effect sizes for improvement were found for resistance training,meditative movement interventions,and exercise-based active videogames.Conclusion:The review identified important gaps in research,including a lack of studies investigating the benefits of group interventions,the characteristics of professionals delivering the interventions associated with better outcomes,and the impact of motivational strategies and of significant others(e.g.,carers)on intervention delivery and outcomes. | Claudio Di Lorito Annabelle Long Adrian Byrne Rowan H.Harwood John R.F.Gladman Stefan Schneider Pip Logan Alessandro Bosco Veronika van der Wardt | 2021 | Journal of Sport and Health Science2021，10，1： | 3 |
| 11 | Coagulopathy in liver disease:Lack of an assessment tool显示文摘There is a discrepancy between the information from clotting tests which have routinely been used in clinical practice and evidence regarding thrombotic and bleeding events in patients with liver disease. This discrepancy leads us to rely on other variables which have been shown to be involved in haemostasis in these patients and/or to extrapolate the behaviour of these patients to other settings in order to decide the best clinical approach. The aims of the present review are as follows:(1) to present the information provided by clotting tests in cirrhotic patients;(2) to present the factors that may influence clotting in these patients;(3) to review the clinical evidence; and(4) to put forward a clinical approach based on the first 3 points. | Annabel Blasi | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 12 | Toluene degradation by a water/silicone oil mixture for the design of two phase partitioning bioreactors显示文摘Toluene degradation performances were studied in a 10 L Two-Phase Partitioning Bioreactor(TPPB).The liquid phase consisted of a mixture of water and PDMS 50(Poly Di Methyl Siloxane,i.e.silicone oil,viscosity of 46 m Pa·s) in the volume ratio of 75%/25%.Two series of experiments were carried out:in the first,the reactor was sequentially supplied with toluene whereas in the second,toluene was continuously supplied.Activated sludge from the wastewater treatment plant of Beaurade(Rennes,France) was used at an initial concentration of 0.5 dry mass g·(mixture L)^(-1).The elimination capacity(EC) was investigated as well as the change in biomass concentration over time.Toluene biodegradation was very ef ficient(removal ef ficiency,RE=100%) for toluene flows ranging from 0.2 to 1.2 ml·h^(-1),corresponding to elimination capacities of up to 104 g·m^(-3)·h^(-1).For a toluene flow of 1.2 ml·h^(-1),the biomass concentration measured at the end of the experiment was 4.7 dry mass g·(mixture L)^(-1).The oxygen concentration in the liquid phase was clearly not a limiting factor in these operating conditions.Based on these results,an extrapolation leading to the design of a large-scale pilot TPPB can now be considered to study toluene degradation performances in industrial conditions. | Maxime Guillerm Annabelle Couvert Abdeltif Amrane Edith Norrant Audrey Breton éric Dumont | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 2 |
| 13 | The N-terminal Pro-BNP Investigation of Dyspnea in the Emergency department (PRIDE) study显示文摘 | James L. Januzzi Carlos A. Camargo Saif Anwaruddin Aaron L. Baggish Annabel A. Chen Daniel G. Krauser Roderick Tung Renee Cameron J. Tobias Nagurney Claudia U. Chae Donald M. Lloyd-Jones David F. Brown Stacy Foran-Melanson Patrick M. Sluss Elizabeth Lee-L | 2005 | The American Journal of Cardiology2005，，8： | 2 |
| 14 | Intensive dialectical behaviour therapy for outpatients with borderline personality disorder who are in crisis显示文摘 | Annabel M D Rosetta M A Florence Guenot M A | 2005 | Psychiatric Serices2005，56，： | 1 |
| 15 | Co-operation,Violation and Making Sense显示文摘 | Annabelle | 2004 | Journal of Pragmatics2004，，36： | 1 |
| 16 | The relationships among verbal short-term memory,phonological awareness,and new word learning:evidence from typical development and down syndrome显示文摘 | Christopher Jarrold Annabel S.C.Thron Emma Stephens | | 0，，02： | 1 |
| 17 | 基于单试验脑电图的n-back任务中的脑力负荷分类(英文)显示文摘近年来,脑力负荷估计已经经历了广泛的研究,因为监测认知负荷的能力能够防止认知超负荷并且改善工作场所安全。脑电图(EEG)信号已经被发现是一种客观和非侵入性的脑力负荷的测量方式。然而,作为实时脑力负荷监测和脑机接口研究的重要一步,基于单试验EEG数据的认知负荷的评估一直是一个重大的挑战。最近,许多高级的特征提取方法和机器学习算法已经被采用于基于EEG的脑力负荷评估中。在本研究中,使用在具有2个难度水平的n-back任务的执行期间记录的EEG数据进行了单试验脑力负荷分类,测试了3种类型的特征提取的有效性(谱功率、离散小波变换和公共空间滤波),并评估了4种分类算法的性能(支持向量机、K-近邻、随机森林和梯度推进分类器)。研究结果表明,公共空间滤波是性能最好的基于单试验的脑力负荷分类的特征提取方法,而且最佳性能可以通过将来自谱功率或离散小波变换的特征与来自公共空间滤波的特征相结合,并采用随机森林分类器来实现。这项研究可能对基于单试验脑电图数据的脑力负荷评估中的特征提取方法以及机器学习算法的选择提供一些有用的指导。 | 代忠祥 Bezerianos Anastasios Chen Shen-Hsing Annabel 孙煜 | 2017 | 仪器仪表学报2017，38，6： | 1 |
| 18 | Crisis sentinel indieators: Averting a potential meltdown in the Coral Triangle显示文摘 | Reniel Cabral Annabelle Cruz-Trinidad Rollan Geronimo et | 2013 | Marine Polie2013，，39： | 1 |
| 19 | Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice 显示文摘 | Karin P Annabelle P Pierre-Y J | 2007 | J Physiol2007，583，2： | 1 |
| 20 | Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor显示文摘 | Xianke Zeng Hua Zhang Annabell Oh Yan Zhang Douglas Yee | 2012 | Breast Cancer Research and Treatment2012，，1： | 1 |
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