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| 1 | Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans显示文摘AIM To determine whether and to what extent the gut microbiome is involved in regulating racial disparity in colorectal cancer(CRC). METHODS All patients were recruited and experiments were performed in accordance with the relevant guidelines and regulations by the Institutional Review Boards (IRB), committees of the John D. Dingell VAMC and Wayne State University guidelines. African American (AA) and Caucasian American (CA) patients were scheduled for an outpatient screening for colonoscopy, and no active malignancy volunteer patients were doubly consented, initially by the gastroenterologist and later by the study coordinator, for participation in the study. The gut microbial communities in colonic effluents from AAs and CAs were examined using 16 sRNA profiling, and bacterial identifications were validated by performing SYBR-based Real Time PCR. For metagenomic analysis to characterize the microbial communities, multiple software/tools were used, including Metastats and R statistical software.RESULTS It is generally accepted that the incidence and mortality of CRC is higher in AAs than in CAs. However, the reason for this disparity is not well understood. We hypothesize that the gut microbiome plays a role in regulating this disparity. Indeed, we found significant differences in species richness and diversity between AAs and CAs. Bacteroidetes was more abundant in AAs than in CAs. In particular, the pro-inflammatory bacteria Fusobacterium nucleatum and Enterobacter species were significantly higher in AAs, whereas probiotic Akkermansia muciniphila and Bifidobacterium were higher in CAs. The polyphyletic Clostridia class showed a divergent pattern, with Clostridium XI elevated in AAs, and Clostridium IV, known for its beneficial function, higher in CAs. Lastly, the AA group had decreased microbial diversity overall in comparison to the CA group. In summary, there were significant differences in pro-inflammatory bacteria and microbial diversity between AA and CA, which may help explain the CRC disparity between groups.CONCLUSION Our current investigation, for the first time, demonstrates microbial dysbiosis between AAs and CAs, which could contribute to the racial disparity of CRC. | Lulu Farhana Fadi Antaki Farhan Murshed Hamidah Mahmud Stephanie L Judd Pratima Nangia-Makker Edi Levi Yingjie Yu Adhip PN Majumdar | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 3 |
| 2 | Hierarchical control of heart- assist devices显示文摘 | Boston JR Antaki JF Simaan MA | 2003 | IEEE Robot Autom Mag2003，10，1： | 1 |
| 3 | Second primary lung cancer显示文摘 | Antaki T Schacfer RF Rutherford JE | 1990 | J Thorac Csrdivasc Surg1990，99，5： | 1 |
| 4 | Ogilvie syndrome and herpes zoster: case report and review of the literature 显示文摘 | Edelman DA Antaki F Basson MD | 2010 | J Emerg Med2010，39，5： | 1 |
| 5 | The unexpected discovery of a focus of hepatitis C virus genotype 5 in a Syrian province显示文摘 | Antaki N Haddad M Kebbewar K | 2009 | Epidemiol Infect2009，137，1： | 1 |
| 6 | A Review of Methods for the Analysis of Burred Pressure Piping显示文摘 | George Antaki | | 0，，9： | 1 |
| 7 | Experimental verification of the feasibility of the cardiovascular im- pedance simulator显示文摘 | Gwak K W Paden B E Antaki J F | 2010 | IEEE Transactions on Biomedic- al Engineering2010，57，5： | 1 |
| 8 | Poisoning due to tricyclic antidepressants in children and adolescems显示文摘 | Antaki AJ | 1979 | Can Med Assoc J1979，120，8： | 1 |
| 9 | Mental-health practitioners' use of idiomatic expressions in summarising clients' accounts 显示文摘 | Antaki C | 2007 | Journal of Pragmatics2007，，： | 1 |
| 10 | CFD-based design optimization of the UoP streamliner rotary blood pump显示文摘 | Antaki JF Wu J | 2000 | Annals of Biomedical Engineering2000，28，1： | 1 |
| 11 | An algorithm combining ultrasound monitoring and urinary luteinizing hormone testing:a novel approach for intrauterine insemination timing显示文摘 | Antaki R Dean NL Lapensee L | 2011 | J Obstet Gynaecol Can2011，33，： | 1 |
| 12 | Collected nondimension performance of rotary dynamic blood pump显示文摘 | Smith W A Allaire P Antaki J | 2004 | ASAIO Journal2004，50，： | 1 |
| 13 | Diagnostic formulations in psychotherapy显示文摘 | Antaki C Barnes R Leudar I | 2005 | Discourse Studies2005，，6： | 1 |
| 14 | Plasma protective effect on red blood cells exposed to mechanical stress显示文摘 | Kameneva MV Antaki iF Yeleswarapu KK | 1997 | ASAIO J1997，43，5： | 1 |
| 15 | Pulsatile perfusion system for ex vivo investigation of biochemical Pathways in intact vascular tissue显示文摘 | LABADIE R F ANTAKI J F WILLIAMS J L | 1996 | The American Journal of Physiology1996，270，2： | 1 |
| 16 | Development of he Nimbus/Pittsburgh axial flow left ventricular assist system显示文摘 | Butler K Thomas D Antaki J | 1997 | Artif Organs1997，21，： | 1 |
| 17 | Self-Disclosure as A Situated Interactional Practice显示文摘 | Antaki C Barness R Leudar I | 2005 | The British Journal of Social Psychology2005，，44： | 1 |
| 18 | A mathematical model for shear-induced hemolysis显示文摘 | Yeleswarapu KK Antaki JG Kameneva MB | 1995 | Artificial Organs1995，19，7： | 1 |
| 19 | Development progress of the university Pittsburg streamliner: a mixed flow blood pump with magnetic bearing显示文摘 | Antaki J F | 2000 | ASAIO J2000，46，2： | 1 |
| 20 | Diagnostic formulations in psychotherapy显示文摘 | ANTAKI C BARNES R LEUDAR I | 2005 | Discourse Studies2005，，6： | 1 |
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