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| 1 | Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection显示文摘Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan. Furthermore, treatment response included decreased diameter of the primary tumor in the tail of the pancreas and disappearance of the additional peritoneal carcinomatosis. Both patients were discussed by our multidisciplinary tumor board, which recommended surgical resections of the carcinoma. The R0 resection of the primary tumor was successful in both cases and, interestingly, the resected tissues showed no evidence of the hepatic metastases intraoperatively. In the first case, the patient received a postoperative 6-mo course of adjuvant chemotherapy with gemcitabine. In the second case, the patient continued to receive the FOLFIRINOX regimen for an additional 6 mo postoperatively. At 12 mo after the operation, a nonresectable retroperitoneal lymph node metastasis was detected in the first patient, whereas the second patient remained in complete remission at the time of this report(5 mo after the adjuvant therapy was discontinued). This case report is the first of its kind to describe two cases of hepatic metastatic pancreatic carcinoma that were resectable following treatment with FOLFIRINOX. Further studies are required to examine the role of FOLFIRINOX as a neoadjuvant treatment option in subgroups of patients with initially metastasized pancreatic carcinoma. | Sophie Schneitler Patric Krpil Jasmin Riemer Gerald Antoch Wolfram Trudo Knoefel Dieter Hussinger Dirk Graf | 2015 | World Journal of Gastroenterology2015，21，20： | 9 |
| 2 | Radioembolization with yttrium‐90 glass microspheres in hepatocellular carcinoma: European experience on safety and long‐term survival显示文摘 | Philip Hilgard Monia Hamami Amr El Fouly André Scherag Stefan Müller Judith Ertle Till Heusner Vito R. Cicinnati Andreas Paul Andreas Bockisch Guido Gerken Gerald Antoch | 2010 | Hepatology2010，，： | 3 |
| 3 | Non-small cell lung cancer: dual-modality PET/CT in preoperative staging显示文摘 | Antoch G Stattaus J Nemat AT | 2003 | Radiology2003，229，2： | 1 |
| 4 | The role of mammalian circadian proteins in normal physiology and genotoxic stress responses显示文摘 | Kondratov R V Gorbacheva V Y Antoch M P | 2007 | Curr Top Dev Biol2007，78，： | 1 |
| 5 | FDG-PET/CT in re-staging of patients with lymphoma 显示文摘 | Freudenberg LS Antoch G Schiitt P | 2004 | Eur J Nuclear Med MolImaging2004，31，3： | 1 |
| 6 | Coordinated transcription of key pathways in the mouse by the circadian clock显示文摘 | Panda S Antoch MP Miller BH | 2002 | Cell2002，109，3： | 1 |
| 7 | Detection of residual tumor after radiofrequency ablation of liver metastasis with dual - modality PET/CT: initial results 显示文摘 | Veit P Antoch G Stergar H | 2006 | Eur Radiol2006，16，1： | 1 |
| 8 | 肿瘤18F-FDG PET/MRI全身显像专家共识(德国)显示文摘PET/MRI一体机在2006年被首次提出可应用于临床;2010年,首台临床型PET/MRI一体机诞生。在20世纪早期,PET/CT和SPECT/CT一体机的广泛应用体现了融合显像的优势,为PET/MRI一体机的产生奠定了基础。目前,全球大约有150台全身PET/MRI一体机投入了临床应用,其中肿瘤显像是PET/MRI的主要应用领域之一。迄今为止,尽管PET/MRI临床应用在增加,但标准化的PET/MRI扫描方案还很少。因此,有必要制定患者检查和多中心研究都可遵循的标准化且一致性好的显像方案。该文总结了18F-脱氧葡萄糖(FDG)PET/MRI全身显像的患者就诊、检查准备、工作流程、显像方案以及报告书写等主要方面的专家共识,由长期使用PET、MRI和较早使用PET/MRI的相关资深专家制定。 | 王洋洋 杨光杰(译) 王振光(审校) Lale Umutlu Thomas Beyer Johannes Stefan Grueneisen Christoph Rischpler Harald H Quick Veit-Haibach Patrick Matthias Eiber Sandra Purz Gerald Antoch Sergios Gatidis Konstantin Nikolaou Jürgen FSchaefer IvoRausch Herrmann Ken K.Herrmann B.J.Krause S.O.Schoenberg L.Umutlu F.Anton G.Antoch M.Hacker M.Luster S.Neumann D.Vorwerk | 2020 | 中华核医学与分子影像杂志2020，40，9： | 1 |
| 9 | Positional synthetic cloning and functional characterization of the mammadian circadian mutation tau显示文摘 | Lowery PL Shimonura K Antoch MP | 2000 | Science2000，288，5465： | 1 |
| 10 | Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53 + / - mice显示文摘 | Komarova E A Antoch M P Novototskaya L R | 2012 | Aging (Albany NY)2012，4，10： | 1 |
| 11 | Accuracy of whole-body dual-mo- dality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomo- graphy and computed (FDG-PFT/CT) for tumor staging in solid tumors:comparison with CT and PET显示文摘 | Antoch G Saoudi N Kuehl H | 2004 | J Clin Oncol2004，22，21： | 1 |
| 12 | Non-small cell lung cancer:dual-modality PET-CT in preoperative staging显示文摘 | Antoch G Stattaus J Nemat AT | 2003 | Radiology2003，229，2： | 1 |
| 13 | Coordinated transcrip-tion of key pathways in the mouse by the circadian clock 显示文摘 | Panda S Antoch MP Miller BH | 2002 | Cell2002，109，3： | 1 |
| 14 | Whole-body PET/CT?colonography , a possible new concept for colorectal cancer staging显示文摘 | Kinner S Antoch G Bockisch A | 2007 | Abdom Imaging2007，32，5： | 1 |
| 15 | Whole-bodydual-modality PET/CT and whole-body MRI for tumor staging in oncology 显示文摘 | Antoch G Vogt FM Freudenberg LS | 2003 | JA- MA2003，290，24： | 1 |
| 16 | Whole-body Dual-modality PET/CT and Whole-body MRI for Tumor Staging in Oncology显示文摘 | Antoch G Vogt FM Freudenberg LS | 2003 | JAMA2003，290，24： | 1 |
| 17 | Dual-modality PET/CT imaging:the effect of respiratory motion on combined image quality in clinical oncology 显示文摘 | Beyer T Antoch G Blodgett T | 2003 | Eur J Nucl Med2003，30，： | 1 |
| 18 | Comparison of PET,dual-modelity PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumors 显示文摘 | Antoch G CT andKanja J Bauer S | 2004 | J Nucl Med2004，45，： | 1 |
| 19 | Dual Modality of ^18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in Patients with Cervical Carcinoma of Unknown Primary显示文摘 | Freudenberg LS Fischer M Antoch G | 2005 | Med Princ Pract2005，14，3： | 1 |
| 20 | Unknown Primary Tumors: Detection with Dual-Modality PET/CT--Initial experience 显示文摘 | Gutzeit A Antoch G Kuhl H | 2005 | Radiology2005，234，1： | 1 |
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