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您的检索式：作者名="Arthur Konnerth"
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| 1 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 2 | Dye loading with patch pipettes显示文摘 | Jens Eilers Arthur Konnerth | | 0，，04： | 1 |
| 3 | Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo显示文摘 | Olga Garaschuk Ruxandra I Milos Arthur Konnerth | | 0，，01： | 1 |
| 4 | Imaging calcium in neurons显示文摘 | Christine Grienberger Arthur Konnerth | | 0，，05： | 1 |
| 5 | 一条空间导航的记忆环路显示文摘文章简介本研究具有相当的挑战性,很大程度上是由于很难使用标准的电生理和成像方法,在动物执行与空间记忆相关的任务时对通路的活动进行实时监测。课题组巧妙地使用光纤光度计,采用Morris水迷宫和八臂迷宫这两个经典的空间记忆行为学范式。 | Han Qin 付玲 Bo Hu Xiang Liao Jian Lu Wenjing He Shanshan Liang Kuan Zhang Ruijie Li Jiwei Yao Junan Yan Hao Chen Hongbo Jia Benedikt Zott Arthur Konnerth 谌小维 | 2019 | 科学新闻2019，0，2： | 0 |
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