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		题名	作者	年代	出处	被引量
	1	Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.	Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki	2006	World Journal of Gastroenterology2006，12，40：	3
	2	Numerical and experimental study of dry cutting for an aeronautic aluminium alloy(A2024-T351)显示文摘	MABROUKI T GIRARD1N F ASAD M	2008	International Journal of Machine Tools and Manufacture2008，48，11：	1
	3	Coagulopathies in Naja naja karachiensis(black Pakistan cobra) bites and its effect on coagulation tests upon storage of platelet-poor plasma显示文摘	Asad MH Razi MT Khan T		0，，06：	1
	4	Theorizing the relationship between NGOs and the state in medical humanitarian develop- ment projects 显示文摘	Asad A L Kay T	2014	Social Science & Medicine2014，120，1982：	1
	5	The diagnosis of growth hormone deficiency in children and adults 显示文摘	Stephen MS Andrew T Asad R	1998	Endocrine Reviews1998，19，2：	1
	6	The effect of disinfec- tion procedures on flexural properties of denture base acrylic resins显示文摘	Asad T AC Watkinson R Huggett	1992	JProsthetDent1992，58，1：	1
	7	Implementing a mathematical model for locating EMS vehicles in fayetteville显示文摘	Asad T Constance L	2004	Computers & Operations Research2004，31，9：	1
	8	A multiprocessmachine tool for compound micromachining显示文摘	Rahman M Asad A B M A Masaki T	2010	InternationalJournal of Machine Tools and Manufacture2010，50，4：	1
	9	The effect of cigarette smoke on airway inflammation in asthma and COPD:therapeutie im- plications显示文摘	Asad T Dzelal S Nicola H	2012	Respiratory medicine2012，106，3：	1
	10	Variability in expression of insecticidal Cry1Ab gene in Indica Basmati rice显示文摘	Husnain T Asad J Maqbool S	2002	Euphytica2002，128，：	1
	11	Effect of atmospheric microwave plasma treatment on organic lubricant on a metallic surface 显示文摘	ASAD S S TENDERO C DUBLANCHE T C	2009	Surface Coatings and Technology2009，203，13：	1

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