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| 1 | Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs显示文摘AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious dogs.METHODS:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist administration.The force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and colon.Test materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive state.The effects of these receptor antagonists on normal gastrointestinal motor activity were analyzed.RESULTS:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal ileum.The 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor activity.In the proximal colon,the inhibitory effect was dose dependent.Dose dependency,however,was not observed in the distal colon.The 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.CONCLUSION:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity.The5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. | Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii Tetsuro Ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Evaluation of 18F-2-deoxy-2-fluoro-d-glucose Positron Emission Tomography for Gastric Cancer显示文摘 | Erito Mochiki Hiroyuki Kuwano Hiroyuki Katoh Takayuki Asao Noboru Oriuchi Keigo Endo | 2004 | World Journal of Surgery2004，，3： | 2 |
| 3 | Laparoscopically assisted total gastrectomy with lymph node dissection for upper and middle gastric cancer显示文摘 | Erito Mochiki Yoshitaka Toyomasu Kyouichi Ogata Hiroyuki Andoh Tetsuro Ohno Ryusuke Aihara Takayuki Asao Hiroyuki Kuwano | 2008 | Surgical Endoscopy2008，，9： | 2 |
| 4 | The common γ chain is an indispensable subunit of IL-2 receptor complex显示文摘 | Asao H Okuyama C Kumaki S | 2001 | J Immunol2001，167，1： | 1 |
| 5 | Autotoxicity of root exudates from taro显示文摘 | ASAO T HASEGAWA K SUEDA Y etal | 2003 | Scientia Horticutture2003，97，34： | 1 |
| 6 | Diffsion-weighted imaging of radiation-induced brain injury for differentiation from tumor recurrence显示文摘 | Asao C Korogi Y Kitajima M | 2005 | AJNR2005，26，6： | 1 |
| 7 | Fucosyltransferase of the peritoneum contributed to the adhesion of cancer cells to the mesothelium 显示文摘 | Nagamachi T Morinaga N | 1995 | Cancer1995，75，6： | 1 |
| 8 | Charge discharge characteristics of carbon-fiber with graphite structure in organic electrolytes containing lithium trifluommethanesulfate and lithium hexafluorophosphate 显示文摘 | ISHIKAWA M MORITA M ASAO M | 1994 | Journal of the Electrochemical Society1994，141，5： | 1 |
| 9 | 显示文摘 | ASAO N MENGGENBATEER SEYA Y | 2012 | Synlett2012，23，1： | 1 |
| 10 | A novel ex vivo method for assaying adhesion of cancer cells to the peritoneum 显示文摘 | Yazawa S Kudo S | 1994 | Cancer Lett1994，78，13： | 1 |
| 11 | Laparoscopically assisted total or distal gastrectomy with lymph node dissection for early gastric cancer显示文摘 | Asao T Hosouchi Y Nakabayashi T | 2001 | Br J Surg2001，88，1： | 1 |
| 12 | Use of a Mattress Suture to Eliminate Dog Ears in Double-Stapled and Triple-Stapled Anastomoses显示文摘 | Takayuki Asao Hiroyuki Kuwano Jun-ichi Nakamura | 2002 | Dis Colon Rectum2002，45，1： | 1 |
| 13 | Laparoscopic assisted or distal gastrectorny with lymph node dissection for early gastric cancer显示文摘 | Asao T Hosouchi Y Nakabayashi T | 2001 | Br J Surg2001，88，： | 1 |
| 14 | Spasmolytic effect of peppermint oil in barium during double-contrast barium enema compared with Buscopan 显示文摘 | Asao T Kuwano H Ide M | 2003 | Clin Radiol2003，58，4： | 1 |
| 15 | Gum chewing enhances early recovery from postoperative fleus after laparoseopie coi eetom显示文摘 | Asao T Kuwano H Nakamura J | 2002 | J Am Coil Surg2002，195，1： | 1 |
| 16 | Autotoxicity of root exudates from taro显示文摘 | ASAO K T HASEGAWA SUEDA Y | 2003 | Scientia Horticulture2003，97，： | 1 |
| 17 | Relationships between levels of urinary podocalyxin, number of urinary podocytes, and histologic injury in adult patients with IgA nephropathy 显示文摘 | Asao R Asanuma K Kodama F | 2012 | Clin J Am Soc Nephrol2012，7，9： | 1 |
| 18 | Antimicrobial and antifungal agents derived from clay minerals (Ⅱ)显示文摘 | Fumihiko Ohashi and Asao Oya | 1992 | Applied clay science1992，，6： | 1 |
| 19 | Synthesis and modeling perspectives ofrhizosphere priming显示文摘 | Cheng WX Parton WJ Gonzalez-Meler MA Phillips R Asao S McNickle GG Brzostek E Jastrow JD | | 0，，： | 1 |
| 20 | Nucleotide sequences and characterization of haemolysin genes from Aeromonas hy- drophila and Aeromonas sobria 显示文摘 | HIRONO I AOKI T ASAO T | 1992 | Microbial Pathogenesis1992，13，6： | 1 |
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