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| 1 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019，25，26： | 3 |
| 2 | A randomized placebo-controlled trial of alphacalcidol on the preservation of beta cell function in children with recent onset type 1 diabetes显示文摘 | Asal Ataie-Jafari Seng-Cheong Loke Asmah B. Rahmat Bagher Larijani Farzaneh Abbasi Melvin K.S. Leow Zaitun Yassin | 2013 | Clinical Nutrition2013，，： | 2 |
| 3 | Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial显示文摘 | Mohammed SE Asmah R Ismail P | 2015 | Drug Des Devel Ther2015，9，： | 1 |
| 4 | In vitro propagation of Acacia hybrid through alginate-encapsulated shoots and axillary buds 显示文摘 | Nor Asmah H Nor Hasnida H Noraliza A | 2012 | African Journal of Biotechnol- ogy2012，11，12： | 1 |
| 5 | Determination of total antioxidant activity in three types of local vegetables shoots and the cytotoxic effect of their ethanolic extracts against different cancer cell lines显示文摘 | Asmah R Vijay K Loo M F | 2003 | Asia Pac J Clin Nutr2003，12，3： | 1 |
| 6 | Acute dengue in a neonate secondary to perinatal transmission 显示文摘 | Chin PS Khoo AP Asmah Hani AW | 2008 | Med J Malaysia2008，63，3： | 1 |
| 7 | New oligonucleotide primers for P-typing of rotavirus strains:Strategies for typing previously untypeable strains显示文摘 | Simmonds M K Armah G Asmah R | 2008 | J Clin Virol2008，42，4： | 1 |
| 8 | Dye-interleaved nanocomposite: Evan's Blue in the lamella of Mg-Al-layered double hydroxide 显示文摘 | Hussein M Z Asmah H Y Lai M P | 2004 | Dyes and Pigments2004，63，： | 1 |
| 9 | Rotavirus G and P genotypes in rural Ghana显示文摘 | Asmah RH Green J Armah GE | 2001 | Journal of Clinical Microbiology2001，39，5： | 1 |
| 10 | Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats显示文摘Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+ 200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties. | Zariyantey ABDUL HAMID Siti Balkis BUDIN Ng WEN JIE Asmah HAMID Khairana HUSAIN Jamaludin MOHAMED | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，3： | 1 |
| 11 | Ion exchange study of carbonate,nitrate and dioctyl sulfosuccinate with anthraquinone-2-sulphonate encapsulated in inorganic layered structures显示文摘 | ASMAH H Y MOHD Z B H WONG S S | 2003 | J Phys Chem Solid2003，64，： | 1 |
| 12 | New oligonucleotide primers for P-typing of rotavirus strains:strategies for typing previously untypeable strains显示文摘 | Simmonds MK Armah G Asmah R | 2008 | J Clin Virol2008，42，4： | 1 |
| 13 | Determination of total antioxidant activity in three types of local vegetables shoots and the cytotoxic effect of their ethanolic extracts against different cancer cell lines显示文摘 | Asmah Rahmat PhD Vijay Kumar BSc Loo Mei Fong BSc | 2003 | Asia Pac J Clin Nutr2003，12，3： | 1 |
| 14 | Identification and Concentration of Some Flavonoid Components in Malaysian Young Ginger (Zingiber officinale Roscoe) Varieties by a High Performance Liquid Chromatography Method 显示文摘 | Ali Ghasemzadeh Hawa Z E Jaafar Asmah Rahmat | 2010 | Molecules2010，15，： | 1 |
| 15 | Effects of variations in culture media and hormonal treatments upon callus induction potential in endosperm explant of Barringtonia racemosa L.显示文摘Objective: To induce callus from the medicinally valuable species, Barringtonia racemosa L.(B. racemosa) whereby the formation of callus is essential for micropropagation studies and in vitro plant secondary metabolites production.Methods: The callus induction potential in B. racemosa was assessed from endosperm explant cultured on different culture media and plant hormonal treatments. Lloyd and Mc Cown's woody plant medium and Murashige and Skoog's medium were used in the study as culture media. On the other hand, various concentrations and combinations of2,4-dichlorophenoxyacetic acid(1.0–2.0 mg/L) and kinetin(0.5–2.5 mg/L) had been incorporated in the culture media to exert the effects of auxin and cytokinin on callus induction.Results: From the present study, it was found that the profuse [(1.681 ± 0.770) g fresh weight,(0.239 ± 0.239) g dry weight] and friable callus formation was optimally produced with desirable morphology and considerable percentage of callus induction(56.70%) in endosperm explants cultured on 1.0 mg/L 2,4-dichlorophenoxyacetic acid and 1.5 mg/L kinetin in Murashige and Skoog's medium.Conclusions: A reliable protocol for inducing callus formation of profuse and friable morphology in endosperm explant of B. racemosa had therefore been successfully established. | Nurul Izzati Osman Norrizah Jaafar Sidik Asmah Awal | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，2： | 1 |
| 16 | Photochemicals and antioxidant activity of different parts of bambangan(Mangifera pajang)and tarap(Artocarpus odoratissimus)显示文摘 | MOHD FADZELLY ABU BAKAR MARYATI MOHAMED ASMAH RAHMATM JEFFREY FRY | 2009 | Food Chemistry2009，113，： | 1 |
| 17 | Rotavirus G and P genotypes in rural Ghana显示文摘 | Asmah RH Green J Armah GE | 2001 | J Clin Microbiol2001，39，： | 1 |
| 18 | Aetiology of acute lower respiratory infections among children under five years in Accra, Ghana 显示文摘 | Adiku TK Asmah RH Rodrigues O | 2015 | Pathogens2015，4，1： | 1 |
| 19 | New oligonucleotide primers for P-typing of rotavirus strains:Strategies for typing previously untypeable strains显示文摘 | Simmonds MK Armah G Asmah R | 2008 | J Clin Virol2008，42，4： | 1 |
| 20 | Effects of Strobilanthes crispus Tea Aqueous Extracts on Glucose and Lipid Profile in Normal and Streptozotocin-Induced Hyperglycemic Rats显示文摘 | A. B. Mohd Fadzelly R. Asmah O. Fauziah | 2006 | Plant Foods for Human Nutrition2006，，1： | 1 |
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