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| 1 | Burden of celiac disease in the Mediterranean area显示文摘AIM: To estimate the burden of undiagnosed celiac disease (CD) in the Mediterranean area in terms of morbidity, mortality and health cost. METHODS: For statistics regarding the population of each country in the Mediterranean area, we accessed authoritative international sources (World Bank, World Health Organization and United Nations). The prevalence of CD was obtained for most countries from published reports. An overall prevalence rate of 1% cases/total population was finally estimated to represent the frequency of the disease in the area, since none of the available conf idence intervals of the reported rates significantly excluded this rate. The distribution of symptoms and complications was obtained from reliable reports in the same cohort. A standardized mortality rate of 1.8 was obtained from recent reports. Crude health cost was estimated for the years between symptoms and diagnosis for adults and children, and was standardized for purchasing power parity to account for the different economic prof iles amongst Mediterranean countries. RESULTS: In the next 10 years, the Mediterranean area will have about half a billion inhabitants, of which 120 million will be children. The projected number of CD diagnoses in 2020 is 5 million cases (1 million celiac children), with a relative increase of 11% compared to 2010. Based on the 2010 rate, there will be about 550 000 symptomatic adults and about 240 000 sick children: 85% of the symptomatic patients will suffer from gastrointestinal complaints, 40% are likely to have anemia, 30% will likely have osteopenia, 20% of children will have short stature, and 10% will have abnormal liver enzymes. The estimated standardized medical costs for symptomatic celiac patients during the delay between symptom onset and diagnosis (mean 6 years for adults, 2 years for children) will be about €4 billion (€387 million for children) over the next 10 years. A delay in diagnosis is expected to increase mortality: about 600 000 celiac patients will die in the next 10 years, with an excess of 44.4% vs age-and sexmatched controls. CONCLUSION: In the near future, the burden of CD will increase tremendously. Few Mediterranean countries are able to face this expanding epidemic alone. | Luigi Greco Laura Timpone Abdelhak Abkari Mona Abu-Zekry Thomas Attard Faouzi Bouguerrà Paskal Cullufi Aydan Kansu Dusanka Micetic-Turk Zrinjka Miak Eleftheria Roma Raanan Shamir Selma Terzic | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 2 | Toppling failure of discontinuous rock slopes and their stabilization显示文摘 | Aydan O Kawamot T | 1987 | Nippon Kogyo Kaishi/Journal of the Mining &Metallurgical Institute of Japan1987，103，1197： | 1 |
| 3 | Dynamic and static stability assessment of rock slopes against wedge failure显示文摘 | KUMER H AYDAN O ULUSAY R | 2000 | Rock Mech Rock Eng2000，33，1： | 1 |
| 4 | Psychological science in cultural context 显示文摘 | GERGEN K J AYDAN G ANDREW L | 1996 | American Psychologist1996，51，5： | 1 |
| 5 | The squeezing potential of rock around tunnels: Theory and prediction with examples taken from Japan显示文摘 | Prof. Dr. ?. Aydan T. Akagi T. Kawamoto | 1996 | Rock Mechanics and Rock Engineering1996，，3： | 1 |
| 6 | Dynamic and static stability assessment of rock slopes against wedge failures显示文摘 | KUMSAR H AYDAN O ULUSAY R | 2000 | Rock Mechanics and Rock Engineering2000，33，1： | 1 |
| 7 | The Squeezing Potential of Rock around Tunnels: Theory and Prediction 显示文摘 | Aydan O Akagi T Kawamoto T | 1993 | Rock Mechanics and Rock Engineering1993，，2： | 1 |
| 8 | Removal of azo dyes from aqueous solutions using calyx arene and 13-eyclodextdn 显示文摘 | Aydan Y Elif Y Mustafa Y | 2007 | Dyes and Pigments2007，74，1： | 1 |
| 9 | The stability of slopes and underground openings against flexural toppling and their stabilization显示文摘 | AYDAN O KAWAMOTO T | 1992 | Rock Mechanics and Rock Engineering1992，25，3： | 1 |
| 10 | Dynamic and static stability assessment of rock slopes against wedge failures显示文摘 | Kumsar H Aydan O Ulusay R | 2000 | Rock Mechanics and Rock Engineering2000，33，1： | 1 |
| 11 | Dynamic and stability assessment of rock slope against wedge failures 显示文摘 | Kumsar H Aydan O Ulusay R | 2000 | Rock Mechanics and Rock Engineering2000，33，1： | 1 |
| 12 | The squeezing potential of rocks around tunnels; Theory and prediction显示文摘 | AYDAN O AKAGI T KAWAMOTO T | 1993 | Rock Mechanics and Rock Engineering1993，26，2： | 1 |
| 13 | ISRM suggested methods tbr determining the creep characteristics of rock显示文摘 | Aydan Omer Ito Takashi Ozbay Ugur | 2014 | Rock Mechanics and Rock Engineering2014，47，1： | 1 |
| 14 | Dynamic and static stability assessment of rock slops against wedge failure显示文摘 | KUMSAR H AYDAN O ULUSAY R | 2000 | Rock Mechanics and RockEngineering2000，33，1： | 1 |
| 15 | The stability of slopes and underground openings against flexural toppling and their stabilisation显示文摘 | Asst. Prof. Dr. ?. Aydan Prof. T. Kawamoto | 1992 | Rock Mechanics and Rock Engineering1992，，3： | 1 |
| 16 | An experimental study on the design parameters of a counterflow vortex tube显示文摘 | Muzaffer Baki | 2005 | Energy2005，9，： | 1 |
| 17 | The effective failure modes and stability of slopes in rock mass with two discontinuity sets显示文摘 | AYDAN (O) SHIMIZU Y ICHIKAWA Y | 1989 | Rock Mechanics and Rock Engineering1989，22，3： | 1 |
| 18 | The Squeezing Potential of Rocks around Tunnels, Theory and Prediction 显示文摘 | Aydan O Akagi T Kawamoto T | 1993 | Rock Mechanics and Rock Engineering1993，26，2： | 1 |
| 19 | The squeezing potential of rock around tunnels: theory and prediction with examples taken from Japan显示文摘 | Aydan O Akagi T Kavamoto T | 1996 | Rock Mechanics and Rock Engineering1996，29，： | 1 |
| 20 | Association or a New Syndrome 显示文摘 | Aydan Degerliyurt Asl Kantar Serdar Ceylaner | 2009 | Pediatric Neurology2009，40，2： | 1 |
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