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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 3 | Quality of life after burn injury:the impact of joint contracture显示文摘 | Leblebici B Adam M Bagis S | | 0，，06： | 1 |
| 4 | Autoimmune thyroid disease in pregnancy and the postpartum period:relationship to spontaneous abortion显示文摘 | BAGIS T GOKCEL A SAYGILI E S | 2001 | Thyroid:Official Journal of the American Thyroid Association2001，11，11： | 1 |
| 5 | BCL-2 and P53 expression in endometrial carcinoma显示文摘 | Erkanli S Eren F Pekin S Bagis T | 2004 | Exp Clin Cancer Res2004，23，1： | 1 |
| 6 | The effect of equilibration time on survival and development rates of mouse pronuclear-stage embryos vit- rified in solid surface (SSV)and convential straws:in vitro and in viwJ evaluations 显示文摘 | Bagis H Mercan HO Cetin S | 2005 | Mol Reprod Dev2005，72，4： | 1 |
| 7 | Study of axial bone mineral density in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type 2 diabetes mellitus显示文摘 | Sahin G Polat G Bagis S | 2002 | J Womens Health (Larchmt)2002，11，9： | 1 |
| 8 | The effect of equilibration time on survival and development rates of mouse pronuclear-stage embryos vitrified in solid surface (SSV) and convential straws:in vitro and in vivo evaluations显示文摘 | Bagis H Mercan HO Cetin S | 2005 | Mol Reprod Dev2005，72，4： | 1 |
| 9 | Non-operativemanagementoftheuhrasoni-callyevaluated appendicela mass显示文摘 | Bagi P Oueholm S | 2008 | Surgeyr2008，101，： | 1 |
| 10 | Acute electrophysiologic effect of pulsed gallium-arsenide low energy laser irradiation on configuration of compound nerve action potential and nerve excitability显示文摘 | Bagis S Comelekoglu U Sahin G | 2002 | Lasers Surg Med2002，30，5： | 1 |
| 11 | Cryogenic effect of antifreeze protein on transgenic mouse ovaries and the production of live offspring by orthotopic transplantation of cryopreserved mouse ovaries显示文摘 | Bagis H Akko(c)T Tas(s)A Aktoprakligil D | | 0，，： | 1 |
| 12 | Study of axial bone mineraldensity in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type 2 diabetes mellitus Womens Health显示文摘 | Sahin G Polat G Bagis S | 2002 | J Womens Health (Larchmt)2002，1，9： | 1 |
| 13 | Gender difference in prevalence of signs and symptoms of temporomandibular joint disorders: a retrospective study on 243 consecutive patients 显示文摘 | Bagis B Ayaz EA Turgut S | 2012 | Int J Med Sci2012，9，7： | 1 |
| 14 | 1a,25-Dihydroxyvitam in D3 stimulates alkaline phosphatase activity and inhibits soft-tissue proliferation in implants of bone matrix显示文摘 | Vukicevic S Stavljenic A Bagi C | 1985 | Clin Orthop Relat Res1985，，196： | 1 |
| 15 | Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction显示文摘 | Ugander M Bagi P S Oki A J | 2012 | JACC: Cardiovascular Imaging2012，5，6： | 1 |
| 16 | Effect of resin cement and ceramic thickness on final color of laminate veneers : an in vitro study 显示文摘 | TURGUT S BAGIS B | 2013 | J Prosthet Dent2013，109，： | 1 |
| 17 | Low-exposure cadmium is more toxic on osteoporotic rat femoral bone: mechanical, bio?chemical, and histopathological evaluation显示文摘 | Comelekoglu U Yalin S Bagis S el al | 2007 | Ecotoxicol Envi?ron Safety2007，66，： | 1 |
| 18 | Colour stability of laminate veneers:An in vitro study显示文摘 | Turgut S Bagis B | 2011 | Journal of dentistry2011，39，： | 1 |
| 19 | Low-exposure cadmium is more toxic on osteoporotic rat femoral bone: Mechanical, biochemical, and histopathological evaluation 显示文摘 | COMELEKOGLU U YALIN S BAGIS S | 2007 | Ecotoxicol Environ Safety2007，66，2： | 1 |
| 20 | Colour stability of laminate veneers : an iet vitro study 显示文摘 | Turgut S Bagis B | 2011 | J Dent2011，393，： | 1 |
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