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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster 显示文摘 | Bai C Connolly B Metzker M L | 2000 | Proc Natl Acad Scl U S A2000，97，3： | 1 |
| 3 | YAG laser percussion drilling of a functional multi-layer thin plate 显示文摘 | WANG A H WANG W Y BAI Z K XIE C S ZENG D W SONG W L | 2007 | Optics & Laser Technology2007，39，： | 1 |
| 4 | Improvement of chlo- roperoxidase stability by covalent immobilization on chitosan membranes 显示文摘 | Zhang L H Bai C H Wang Y S | 2009 | Biotechnol Leu2009，31，： | 1 |
| 5 | Comprehensive scanning of somatic mitoehondrial DNA mutations in breast cancer 显示文摘 | Tan D J Bai R K Wang L J C | 2002 | Cancer Res2002，62，4： | 1 |
| 6 | Functionalization of adsorbent with different aliphatic polyamines for heavy metal ion removal: characteristics and performance显示文摘 | Liu C Bai R Hong L Liu T | 2010 | J Colloid lnterface Sci2010，345，2： | 1 |
| 7 | Experimental study on the NO and N20 formation characteristics during biomass com- bustion 显示文摘 | Bai J Yu C Li L | 2012 | Energy &Fuels2012，27，1： | 1 |
| 8 | Gold hollow nanospheres : Tuna- ble surface plasmon resonance controlled by interior-cavity sizes 显示文摘 | Liang H P Wan L J Bai C L | 2005 | J Phys Chem B2005，109，16： | 1 |
| 9 | Validation of a major QTL for scab resistance with SSR markers and use of markerassisted selection in wheat显示文摘 | Zhou W C Kolb F L Bai G H | 2003 | Plant Breeding2003，122，1： | 1 |
| 10 | Genetic analysis of scab resistance QTL in wheat with microsatellite and AFLP markers显示文摘 | Zhou W C Kolb F L Bai G H | 2002 | Genome2002，45，： | 1 |
| 11 | Halichondrin B andhomohalichondrin B, marine natural products binding in the vincadomain of tubulin 显示文摘 | BAI R L PAULL K D HERALD C L | 1991 | J Biol Chem1991，266，15： | 1 |
| 12 | Preparation of metal sulfide-polymer composite microspheres with patterned surface structures显示文摘 | FANG Y BAI C L ZHANG Y | 2004 | Chem Commun2004，，： | 1 |
| 13 | Community detection based on modularity and an improved genetic algorithm 显示文摘 | SHANG R H BAI J JIAO L C | 2013 | Physica A: Statistical Mechanics and its Applications2013，392，5： | 1 |
| 14 | Incentives for C EOs with Multitasks :Evidence from Chinese State-Owned Enterprises显示文摘 | BAI C XU L | 2005 | Journal of Comparative Economic2005，33，3： | 1 |
| 15 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
| 16 | Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, dia- betes and the metabolic syndrome in Taiwan 显示文摘 | Hwang L C Bai C H Sun C A | 2012 | Asia Pac J Clin Nutr2012，21，2： | 1 |
| 17 | Well-defined Fullerene Nanowire Arrays 显示文摘 | Hu J S Wan L J Bai C L Bai C L | 2003 | Adv Funct Mater2003，13，8： | 1 |
| 18 | Effect of individual Sumai 3 chromosomes on resistance to scab spread within spikes and deoxynivalenol accumulation within kernels in wheat显示文摘 | Zhou W C Kolb F L Bai G H etal | 2002 | Hereditas2002，137，： | 1 |
| 19 | Switchable single-polarization dual-wavelength ring laser based on structured PM-CFBG显示文摘 | YIN B FENG S C BAI Y L | 2014 | IEEE Photonics Technology Letters2014，26，12： | 1 |
| 20 | Tribological mechanism of hydrogenated amorphous carbon film against pairs: A physical description显示文摘 | Bai L C Zhang G A Lu Z B | 2011 | J Appl Phys2011，110，03： | 1 |
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