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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | The dynamics of firms ina micro-to-macro model: the role of training, learningand innovation显示文摘 | BALLOT G TAYMAZ E | 1997 | Journal of Evolutionary Economics1997，7，4： | 1 |
| 3 | Firms' human capital, R&D and performance: A study on French and Swed- ish firms显示文摘 | Ballot G Fakhfakh F Taymaz E | 2001 | Labour Economics2001，8，4： | 1 |
| 4 | Firms,human capital, R&D and performance : A study on French and Swed-ish firms 显示文摘 | Ballot G Fakhfakh F Taymaz E | 2001 | Labour Economics2001，8，4： | 1 |
| 5 | The reduction of greenhouse gas emissions from freight transport by pooling supply chains显示文摘 | Pan S Ballot E Fontane F | 2013 | International Journal of Production Economics2013，143，1： | 1 |
| 6 | Firms' human capital,R&D and performance:a study on French and Swedish firms显示文摘 | BALLOT G FAKHFAKH F TAYMAZ E | 2001 | Labour Economics2001，8，4： | 1 |
| 7 | The reduction of greenhouse gas emissions from freight transport by pooling supply chains 显示文摘 | Pan S Ballot E Fontane F | 2013 | International Journal of Production Economics2013，143，1： | 1 |
| 8 | Auto-antibodies in autoimmune hep- atitis: anti-smooth muscle antibodies (ASMA)显示文摘 | JOHANET C BALLOT E | 2012 | Clin Res Hepatol Gastroenterol2012，36，2： | 1 |
| 9 | Firm's human capital, R&D and performance: A study on french and swedish firms显示文摘 | BALLOT G FAKHFAKH F TAYMAZ E | 2001 | Labour Economics2001，8，： | 1 |
| 10 | Antibodies to soluble liver antigen: an additional marker in type 1 autoimmune hepatitis显示文摘 | Ballot E Homberg JC Johanet C | 2000 | J Hepatol2000，33，2： | 1 |
| 11 | Auto-antibodies in autoimmune hepatitis:antismooth muscle antibodies (ASMA)显示文摘 | Johanet C Ballot E | | 0，，： | 1 |
| 12 | Detection on immunoblot of new proteins from the soluble fraction of the cell recognized either by anti-liver-kidney microsome antibodies type 1 or by anti-liver cytosol antibodies type 1-relationship with hepatitis C virus infection显示文摘 | Desbos A Monier JC | 1996 | Clin Immunol Immunopathol1996，80，3： | 1 |
| 13 | Detection on immunoblot of new proteins from the microsomal fraction recognized by anti - liver- kidney microsome antibodies type 1 显示文摘 | Desbes A Auger C | 1996 | Clin Immunol Immunopathol1996，80，： | 1 |
| 14 | Firms' human capital, R&D and performance: A study on French and Swed- ish finns显示文摘 | Ballot G Fakhfakh F Taymaz E | 2001 | Labour Economics2001，8，4： | 1 |
| 15 | Firms' human capital, R&D and performance: a study on French and Swedish firms显示文摘 | Ballot G Fakh F Taymaz E | 2001 | Labour economics2001，8，4： | 1 |
| 16 | Reducing transportation CO2e- missions through pooling of supply networks:perspectives from a case study in French retail chains 显示文摘 | BALLOT E FONTANE F | 2010 | Production Planning & Control2010，21，6： | 1 |
| 17 | Diagnostic value of anti-F-actin antibodies in a French multicenter study显示文摘 | CHRETIEN-LEPRINCE P BALLOT E ANDRE C | 2005 | Ann N Y Acad Sci2005，1050，： | 1 |
| 18 | Firm's human capital,R&D and performance: a study on French and Swedish firms显示文摘 | Fakhfakh F Taymaz E | 2001 | Labour Economics2001，，8： | 1 |
| 19 | Significance of antibodies to soluble liver antigen/liver pancreas:a large French study显示文摘 | Eyraud V Chazouillières O Ballot E | | 0，，： | 1 |
| 20 | Firms'human cap-ital,R&D and performance:a study on French and Swed-ish firms显示文摘 | BALLOT G FAKH F TAYMAZ E | 2001 | Labor Economics2001，8，4： | 1 |
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