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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Fast-track rehabilitation program vs conventional care after colorectal resection:A randomized clinical trial显示文摘AIM:To compare the fast-track rehabilitation program and conventional care for patients after resection of colorectal cancer.METHODS:One hundred and six consecutive patients who underwent fast-track rehabilitation program were encouraged to have early oral feeding and movement for early discharge,while 104 consecutive patients underwent conventional care after resection of colorectal cancer.Their gastrointestinal functions,postoperative complications and hospital stay time were recorded.RESULTS:The restoration time of gastrointestinal functions in the patients was significantly faster after fasttrack rehabilitation program than after conventional care(2.1 d vs 3.2 d,P < 0.01).The percentage of patients who developed complications was significantly lower 30 d after fast-track rehabilitation program than after conventional care(13.2% vs 26.9%,P < 0.05).Also,the percentage of patients who had general complications was significantly lower 30 d after fast-track rehabilitation program than after conventional care(6.6% vs 15.4%,P < 0.05).The postoperative hospital stay time of the patients was shorter after fast-track rehabilitation program than after conventional care(5 d vs 7 d,P < 0.01).No significant difference was observed in the readmission rate 30 d after fast-track rehabilitation program and conventional care(3.8% vs 8.7%).CONCLUSION:The fast-track rehabilitation program can significantly decrease the complications and shorten the time of postoperative hospital stay of patients after resection colorectal cancer. | Gang Wang Zhi-Wei Jiang Jing Xu Jian-Feng Gong Yang Bao Li-Fei Xie Jie-Shou Li | 2011 | World Journal of Gastroenterology2011，17，5： | 43 |
| 3 | Entrance Effect on Load Capacity of Orifice Compensated Aerostatic Bearing with Feeding Pocket显示文摘The current research of the aerostatic thrust bearing mainly focuses on the porous material bearing and inherent compensated air bearing, which aims at obtaining small physical dimension and large load capacity. Although porous material bearing appears larger load capacity, materials anisotropy itself and void content distortion caused in heat-treating, and machining processes add greater complexity to internal flow transfer process. Inherent compensated air bearing has the advantages of simple structure and good stability, but its load capacity and static stiffness is not worth somewhat. In this paper, based on hydrostatic lubrication theory, finite volume method is presented for taking entrance effects into account in computing pressure distribution, load capacity and mass flow rates of circular aerostatic thrust bearings. Technical analysis, numerical simulations and laboratory demonstration tests of influence of pocket diameter and pocket depth on loading capacity of aerostatic thrust bearing are carried out on simple orifice compensated air bearings with feeding pockets. The static parameters, such as air consumption and pressure distributions, are measured as a function of supply pressure and air gap height for several different orifices and pockets size. Entrance effects are described in term of typical throttling types, and the effect of pocket diameter and pocket depth on load capacity is systematically described respectively. The proposed research results uncover the causation of throttling action of the orifice compensated air bearing with feed pocket and further develop and improve the design theory of air bearing. | LONG Wei BAO Gang | 2010 | Chinese Journal of Mechanical Engineering2010，23，4： | 11 |
| 4 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 5 | Routing protocol based on social characteristics for opportunistic networks显示文摘Opportunistic networks are derived from delay tolerant networks, where mobile nodes have no end-to-end connections. Nodes are represented by people, which means that opportunistic networks can be regarded as social networks. Human mobility plays an important role in affecting the performance of forwarding protocols in social networks, furthermore, the trajectory of people's movements are driven by social characteristics. However, current routing protocols rely on simple mobility models, and rarely consider social characteristics. Considering two heterogeneous network models, an social opportunistic networks routing(SONR) was proposed which brings an adapted discrete Markov chain into nodes' mobility model and calculates the transition probability between successive status. Comparison was made between Spray, Wait and Epidemic protocol. Simulation show that SONR can improve performance on delivery ratio, delivery latency and network overhead, meanwhile. SONR approaches the performance of Epidemic routing. | CHENG Gang SONG Mei ZHANG Yong XING Yi-hai BAO Xu-yan | 2014 | The Journal of China Universities of Posts and Telecommunications2014，21，1： | 8 |
| 6 | Effect of atorvastatin on non-ischemic heart failure and matrix metalloproteinase-2 and 9 in rats显示文摘目的:那 atorvastatin 与 non-ischemic etiology.Methods 在 heartfailure 禁止 MMP-2 和 9 表示在 volume-overload-induced heartfailure 上检验 atorvastatin 的角色并且测试假设:动静脉( AV )对待管的老鼠是 administeredwith atorvastatin ( 3 mg ·k g^(为 17 weeks.Ventricular 肥大和 heartfailure 的 -1)·d^(-1))or 车辆被 echocardiography 估计,B类型 natriuretic 肽 BNP mRNA 水平 andmorphological measurement.MMP-2,9 | Gang CHENG Geng XU Hong-wen CAI Hui-hua WANG Xiao-feng BAO | 2007 | Acta Pharmacologica Sinica2007，28，4： | 7 |
| 7 | INVERSE MEDIUM SCATTERING PROBLEMS IN NEAR-FIELD OPTICS显示文摘一个调整递归的 linearization 方法为散布在近地的光学产生的问题的二维的反的媒介被开发,它重建从通过光子扫描可存取的数据在同类的底层上扔的不同类的媒介的 scatterer 通道显微镜学实验。除了散布问题的逆的 ill-posedness,二个困难从分层的背景媒介和有限的孔数据产生。基于散布数据的多重频率,从相应于在低频率的弱散布的出生的近似的方法开始,每更改被解决 Helmholtz 方程的一个前面的问题和问题伴随问题关于波浪数字经由递归的 linearization 获得。数字实验被包括说明建议方法的可行性。 | Gang Bao Peijun Li | 2007 | Journal of Computational Mathematics2007，25，3： | 7 |
| 8 | Paeonivayin, A New Monoterpene Glycoside from Paeonia delavayi显示文摘A new monoterpenc glycoside named paeonivayin with other seven known compounds were isolated from the roots of Paeonia delavayi Franch, and their structures were determined bymeans of spectroscopic studies. | Yun Bao MA Da Gang WU Ji Kai LIU (Department of Phytochemistry,Kunming Institute of Botany.The Chinese Academy of Sciences.Kunming 650204) | 1999 | Chinese Chemical Letters1999，10，9： | 7 |
| 9 | A cross-sectional survey on the prevalence of anxiety symptoms in Chinese patients with premature ventricular contractions without structural heart disease显示文摘 | LIANG Jin-jun HUANG He YANG Bo WAN Jun TANG Yan-hong BAO Ming-wei ZHAO Qin-yan wu Gang HUANG Cong-xin | 2012 | Chinese Medical Journal2012，，14： | 7 |
| 10 | Longitudinal study of a community hospital integrated model for diabetes management in the Beijing Jingsong community显示文摘Objective:To determine the effects of a community hospital integrated model on the longitu-dinal management of diabetic patients.Methods:Four hundred forty-one patients with type 2 diabetes residing in Jingsong Commu-nity were randomly assigned to intensive and standard groups.Metabolic parameters were meas-ured in the two groups at baseline and after 36 months of management to compare the rate of goal achievement.Results:After comprehensive management,the overall control rate in the intensive group was increased from 2.7%to 9.6%compared with 2.3%-4.5%in the standard group.Specifically,the control rates for fasting plasma glucose,glycosylated hemoglobin,and blood pressure in the intensive group were significantly increased from 54.1%,40.0%,and 68.2%to 85.5%,74.6%,and 89.1%,respectively.The control rate for glycosylated hemoglobin in the intensive group was significantly higher than the standard group after 36 months of treatment.Conclusion:The community hospital integrated model for longitudinal management effec-tively improved the control rate of glycosylated hemoglobin and the overall control rate in patients with type 2 diabetes. | Jiandong Zhang Ning Zhuang Mingxia Yuan Lijuan Gao Chuan Bian Huaining Chen Qing Chi Suqing Hui Guiying Li Yanli Su Hongsong Bao Gang Wan Guangran Yang Shenyuan Yuan | 2014 | Family Medicine and Community Health2014，2，1： | 7 |
| 11 | CELL AND MOLECULAR BIOMECHANICS: PERSPECTIVES AND CHALLENGES显示文摘As an intriguing interdisciplinary research field,cell and molecular biomechanics is at the cutting edge of mechanics in general and biomechanics in particular.It has the potential to provide a quantitative understanding of how forces and deformation at tissue,cellular and molecular levels affect human health and disease.In this article,we review the recent advances in cell and molecular biomechanics,examine the available computational and experimental tools,and discuss important issues including protein deformation in mechanotransduction,cell deformation and constitutive behavior,cell adhesion and migration,and the associated models and theories.The opportunities and challenges in cell and molecular biomechanics are also discussed.We hope to provide readers a clear picture of the current status of this field,and to stimulate a broader interest in the applied mechanics community. | Baohua Ji Gang Bao | 2011 | Acta Mechanica Solida Sinica2011，24，1： | 7 |
| 12 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 13 | Receptor tyrosine kinases positively regulate BACE activity and Amyloid-β production through enhancing BACE internalization显示文摘Amyloid-β (AP) peptide, the primary constituent of senile plaques in Alzheimer's disease (AD), is generated byβ-secretase- and γ-secretase-mediated sequential proteolysis of the amyloid precursor protein (APP). The aspartic pro-tease, β -site APP cleavage enzyme (BACE), has been identified as the main P-secretase in brain but the regulation of itsactivity is largely unclear. Here, we demonstrate that both BACE activity and subsequent Aβ production are enhancedafter stimulation of receptor tyrosine kinases (RTKs), such as the receptors for epidermal growth factor (EGF) and nervegrowth factor (NGF), in cultured cells as well as in mouse hippocampus. Furthermore, stimulation of RTKs also inducesBACE internalization into endosomes and Golgi apparatus. This enhancement of BACE activity and Aβ production uponRTK activation could be specifically inhibited by Src family kinase inhibitors and by depletion of endogenous c-Src withRNAi, and could be mimicked by over-expressed c-Src. Moreover, blockage of BACE internalization by a dominantnegative form of Rab5 also abolished the enhancement of BACE activity and Aβ production, indicating the requirementof BACE internalization for the enhanced activity. Taken together, our study presents evidence that BACE activity andAβ production are under the regulation of RTKs and this is achieved via RTK-stimulated BACE internalization, andsuggests that an aberration of such regulation might contribute to pathogenic Aβ production. | Lin Zou Zhu Wang Li Shen Guo Bin Bao Tian Wang Jiu Hong Kang Gang Pei | 2007 | Cell Research2007，17，5： | 5 |
| 14 | Advances and Prospects of Surface Modification on Nickel-Rich Materials for Lithium-Ion Batteries显示文摘Although layered Ni-rich cathode materials have attracted lots of attention for their high capacity and power density,several significant issues,such aspoor thermal stability and moderate oyclability lit their practical appications.Most of these undesired problems of Ni-rich materials are caused by theunstable surface or the parasic reactions at cathode-electrolyte interface.5urface coating is the most common method to suppress such interfacialproblems for Ni-rich materials.This review focuses on the surface engineering of the N-rich materials in recent years,including the species used in coat.ing synthetic strategies of uniform coating layer,and the positive effects of coating species on the active materials.Detailed discussions are also taken todescribe the formation mechanism of the surface coating layer with design philosophy.Finally,the prospects for further developments and challenges insurface coating are also summarized. | Yuefeng Su Gang Chen Lai Chen Qing Li Yun Lu Liying Bao Ning Li Shi Chen Feng Wu | 2020 | Chinese Journal of Chemistry2020，38，12： | 5 |
| 15 | Liver Med23 ablation improves glucose and lipid metabolism through modulating FOX01 activity显示文摘 | Yajing Chu Leonardo Gomez Rosso Ping Huang Zhichao Wang Yichi Xu Xiao Yao Menghan Bao Jun Yan Haiyun Song Gang Wang | 2014 | Cell Research2014，24，10： | 5 |
| 16 | A scenario-based clean diesel production strategy for China National Petroleum Corporation显示文摘Facing increasingly strict environmental regulations on transportation fuels,China National Petroleum Corporation(CNPC),the second largest supplier of petroleum products in China,needs to upgrade its transportation fuels.Using the scenario-based analysis method,this paper analyzes how the output and emission related properties,including cetane number,and sulfur and aromatics contents of diesel produced by CNPC,will vary with changes in the configuration of diesel production units in the next 5-10 years.The results showed that,to upgrade its diesel,CNPC needs to adjust its diesel pool by decreasing the share of fluid catalytic cracking(FCC) diesel and increasing the shares of hydrocracking(HDC) and hydrotreating(HDT) diesel.Furthermore,to produce ultra-low-sulfur diesel,straight-run diesel as well as poor diesel blendstocks such as FCC diesel and coker diesel should be hydrotreated before being blended into finished diesel.Developing highly efficient HDC and HDT catalysts and corresponding processes is the key to CNPC economically producing more and cleaner diesel. | Liu Haiyan Yu Jianning Fan Yu Shi Gang Bao Xiaojun | 2011 | Petroleum Science2011，8，2： | 5 |
| 17 | Preparation and characterizations of helical mesoporous silica nanorods using CTAB and alcohols显示文摘螺旋状的 mesoporous 硅石 nanorods 被准备把 cetyltrimethylammonium 溴化物和 achiral 白酒用作 co-structure-directing 代理人。他们用扫描电子显微镜学,传播电子显微镜学,氮吸着,和小角度 X 光检查衍射的地排放被描绘。硅石 nanorods 的长度与增加白酒的长度增加。当 n-heptanol 和 n-octanol 被使用时,有表面上的薄片状的 mesopores 的螺旋状的 mesoporous 硅石 nanorods 被获得。 | Yun Yue Pu Yi Li Wei Zhuang Ming Zhang Bao Zong Li Yong Gang Yang | 2012 | Chinese Chemical Letters2012，23，10： | 5 |
| 18 | A New 24, 30-Dinortriterpenoid from Paeonia delavayi显示文摘A new triterpenoid, 3(, 4(, 23-trihydroxy-24, 30-dinorolean-12, 20(29)-dien-28-oic acid, together with five known compounds, 2(, 3(, 23-trihydroxy-12-oleanen-28-oic acid-(-D-glucopyranosyl ester, palbinone, 2-hydroxy-benzoic acid, vanillic acid, syringic acid, were isolated from the roots of Paeonia delavayi Franch. Their structures were characterized by spectral analysis. | Shao Hua WU, Xiao Dong LUO, Yun Bao MA, Xiao Jiang HAO, Da Gang WU* Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 | 2001 | Chinese Chemical Letters2001，12，4： | 5 |
| 19 | The characteristic periodicity analysis of the radio flux variability of quasar PKS 1510-089显示文摘A wavelet analysis method is introduced to study the possible periods of PKS 1510-089 in radio bands. By compiling the radio light curve of PKS 1510-089 at frequencies of 22 and 37 GHz from 1990 to 2005, and using the wavelet analysis method, the evidence of quasi-periodic activity in PKS 1510-089 was obtained. The results indicate that: (1) There are two stable outburst periods of T1=(1.80±0.06) yr and T2= (0.90±0.07) yr presenting in the isoplethal map of PKS 1510-089 at the radio band 37 GHz; (2) there is an outburst period of T1=(1.80±0.06) yr presenting at the radio band 22 GHz; (3) by the continuum of the isograms map, we find the primary period of PKS 1510-089 is T1=(1.80±0.06) yr, and the period of T2= (0.90±0.07) yr may be the half period. The above results are consistent with the reports of Xie et al. (2004, 2005, 2008), Wu et al. (2005) and Liu & Fan (2007), using the other methods. We can expect that the next burst will be in January 2011. | ZHANG HaoJing ZHAO Gang ZHANG Xiong DONG FuTong XIE ZhaoHua YI TingFeng ZHENG YongGang BAO YuYing | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，9： | 4 |
| 20 | Evolution of precipitates in Ni-Co-Cr-W-Mo superalloys with different tungsten contents显示文摘The Ni-Co-Cr-W-Mo system is critical for the design of nickel-based superalloys.This system stabilizes different topologically close-packed(TCP)phases in many commercially superalloys with high W and Mo contents.Scanning electron microscopy(SEM),transmission electron microscopy(TEM)and thermodynamic calculations were applied to investigate the thermodynamics of the precipitates in two different W-contained Ni-Co-Cr-WMo superalloys(Alloy 1 and Alloy 2).Computational thermodynamics verifies the experimental observation of theμphase formation as a function of temperature and alloy chemistry,but the kinetics for the precipitation of the M6 C phase do not agree with the experimental findings.The major precipitates of Alloy 1 at temperatures of700℃and 750℃during long-time exposure are M23 C6,γ′phase and MC;for Alloy 2,they are M23 C6,γ′phase,MC,M6 C andμphase.W addition is found to promote the precipitation of M6 C andμphase during exposure.M6 C has higher W and lower Ni content thanμphase,whereas M6 C is an unstable phase that would transform into M12 C after 5000-h exposure at 750℃.A great quantity of needle-likeμphases precipitated after exposure at 750℃for5000 h,which have no effect on the impact properties of Alloy 2. | Han-Sheng Bao Zhi-Hua Gong Zheng-Zong Chen Gang Yang | 2020 | Rare Metals2020，39，6： | 4 |
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