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| 1 | Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model显示文摘AIM:To investigate the role of epidermal growth factor receptor(EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor erlotinib.METHODS:Sprague-Dawley rats received trinitrobenzene sulfonic acid(TNBS;30 mg in 50% ethanol,ic),followed 6 wk later by reactivation with TNBS(5 mg/kg,iv) for 3 d.To induce colitis-associated dysplasia,rats then received TNBS(iv) twice a week for 10 wk.One group received erlotinib(10 mg/kg,ip) for 1 wk before the start of the reactivation of the colitis and 2 wk after(21 d);the rest received the vehicle.After rats were euthanized,the colons were removed and analyzed for damage and expression of the EGFR downstream effectors Erk1/2 and c-Myc.RESULTS:Ninety percent of the vehicle-treated animals had dysplasia in any region of the colon.Erlotinib-treated animals had a significant decrease in the incidence of dysplasia compared to vehicle-treated animals in all regions of the colon(50.00% ± 11.47% vs 90.00% ± 10.00% in proximal,P < 0.05;15.00% ± 8.19% vs 50.00% ± 16.67% in mid,P < 0.05;and 20.00% ± 9.17% vs 70.00% ± 15.28% in distal,P < 0.01).Erlotinib-treated animals also had reduced cell proliferation,reduced active Erk1/2,and reduced c-Myc in colon epithelium compared with the vehicle-treated animals.In vitro,erlotinib treatment was shown to markedly decrease c-Myc and pErk1/2 levels in rat epithelial cells.Proliferation of rat epithelial cells was stimulated by epidermal growth factor and inhibited by erlotinib(P < 0.05).CONCLUSION:Erlotinib can decrease the development of colitis-associated dysplasia,suggesting a potential therapeutic use for erlotinib in patients with long-standing colitis. | Beatriz Pagán Angel A Isidro Myrella L Cruz Domenico Coppola Caroline B Appleyard | 2011 | World Journal of Gastroenterology2011，17，44： | 1 |
| 2 | Optical UWB pulse generator using an N tap microwave photonic filter and phase inversion adaptable to different pulse modulation formats 显示文摘 | MARIO B JOSE M BEATRIZ O | 2009 | Optics Express2009，17，7： | 1 |
| 3 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 4 | Lactic acid bacteria and yeasts associated with spontaneous fermentations during the production of sour cassava starch in Brazil显示文摘 | Inayara C A L Rose L M Beatriz M B | 2005 | Food Microbiology2005，105，： | 1 |
| 5 | 查看详情显示文摘 | Sanchez C Beatriz J Philippe B Michael P | | 0，，： | 1 |
| 6 | Highly chirped single-bandpass microwave photonic filter with reconfiguration capabilities 显示文摘 | MARIO B MORA J BEATRIZ O | 2011 | Opt Express2011，19，5： | 1 |
| 7 | Competitive policies for commercial sea ports in the EUA显示文摘 | Carlos P L Beatriz B | 2004 | Marine Policy2004，，28： | 1 |
| 8 | Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival显示文摘 | ANTONIO M BEATRIZ B FRANCESC B | 2004 | Am J Pathol2004，164，2： | 1 |
| 9 | Ethanol production from non starch carbohydrates of wheat bran 显示文摘 | BEATRIZ P A PAVLA C B GALBE M | 2005 | Bioresource Technology2005，96，7： | 1 |
| 10 | A clean process for the production of oxygenated limonene derivatives starting from orange oil显示文摘 | BEATRIZ A ANDREA D L NATALIA B | 2007 | Journal of Chemical Technology and Biotechnology2007，82，6： | 1 |
| 11 | Determination of or gan phosphorus pesticides in fruit juices by matrix solid- phase dispersion and gas ehromatography显示文摘 | Beatriz Consuelo S N B Josea L T | 2003 | J Agric Food Chem2003，51，： | 1 |
| 12 | Simultaneous classification of teas according to their varieties and geographical origins by using NIR spectroscopy and SPA-LDA 显示文摘 | Paulo H G D D Adriann A G Marcelo F P Beatriz S F B M6rio C U A | 2014 | Food Analytical Methods2014，7，8： | 1 |
| 13 | A study of the retrogradation process in five argentine rice starches显示文摘 | LAURA B ITURRIAGA BEATRIZ LOPEZ DE MISHIMA MARIA C ANON | 2009 | LWT - Food Science and Technology2009，43，4： | 1 |
| 14 | An unusual metastatic renal cell carcinoma with maintained complete response to sunitinib treatment 显示文摘 | Chara L Beatriz Redrtguez B Holgado E | 2011 | Case Rep Oncol2011，4，3： | 1 |
| 15 | Xnalysis of pesticides in honey by solid-phase extraction and gas chromatography-mass spectrometry显示文摘 | BEATRIZ A CONSUELO S B JOSE L T | 2004 | Journal of Agriculture and Food Chemistry2004，52，19： | 1 |
| 16 | Volatile Nitrosamines in Fried Bacon显示文摘 | Beatriz M A James F B Scanlan R A | 1997 | Agffculture and Food Chemistry1997，45，： | 1 |
| 17 | Near-infrared fluores- cence cholangiopancreatoscopy: initial clinical feasibility re- sults显示文摘 | Glitz G Beatriz GA Valentin B | 2014 | Gastrointest Endosc2014，79，4： | 1 |
| 18 | Effect of amiodarone on haemodynamics during cardiopulmonary resuscitation in a canine model of resistant ventricular fibrillation显示文摘 | Paiva Edison F Perondi Maria Beatriz M Kern Karl B | 2003 | Resuscitation2003，58，2： | 1 |
| 19 | Antimicrobial activity of nisin against Oenococcus oeni and other wine bacteria显示文摘 | BEATRIZ R B SAENZ Y MYRIAM Z | 2007 | International Journal of Food Microbiology2007，116，1： | 1 |
| 20 | Relationship between blood con- centrations of heavy metals and cytogenetic and endocrine parameters a- mong subjects involved in cleaning coastal areas affected by the 'Pres- tige' tanker oil spill显示文摘 | Beatriz P C Laffon B Porta M | 2008 | Chemosphere2008，71，3： | 1 |
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